Testing the Exon Theory of Genes: The Evidence from Protein Structure

Savitzky-Golay Smoothing Filters

1990 • 11,997 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Multiple sequence alignment with hierarchical clustering

1988 • 5,250 citations

CLUSTAL: a package for performing multiple sequence alignment on a microcomputer

1988 • 3,446 citations

Introduction to Protein Structure

2012 • 2,404 citations

Why genes in pieces?

1978 • 2,256 citations

Molecular Biology of the Gene

1970 • 2,116 citations

Fast and sensitive multiple sequence alignments on a microcomputer

1989 • 1,245 citations

Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5Å resolution: using amino acid sequence data

1975 • 638 citations

Genes in pieces: were they ever together?

1978 • 440 citations

The Exon Theory of Genes

1987 • 395 citations

Correlation of DNA exonic regions with protein structural units in haemoglobin

1981 • 394 citations

Intron phylogeny: a new hypothesis

1991 • 361 citations

Molecular analysis of the alcohol dehydrogenase 2 (Adh2) gene of maize

1985 • 338 citations

Implications of RNA⋅RNA Splicing in Evolution of Eukaryotic Cells

1978 • 333 citations

On the antiquity of introns

1986 • 324 citations

Do genes-in-pieces imply proteins-in-pieces?

1978 • 287 citations

Intron phylogeny: a new hypothesis

1991 • 278 citations

Three Dimensional Fourier Synthesis of Horse Deoxyhaemoglobin at 2.8 Å Resolution

1970 • 271 citations

Features of spliceosome evolution and function inferred from an analysis of the information at human splice sites

1992 • 268 citations

The recent origins of introns

1991 • 263 citations

Splice Junctions: Association with Variation in Protein Structure

1983 • 261 citations

The structure of cat muscle pyruvate kinase.

1986 • 245 citations

Evidence that introns arose at proto-splice sites.

1989 • 235 citations

Crystallographic investigations of nicotinamide adenine dinucleotide binding to horse liver alcohol dehydrogenase

1984 • 235 citations

How Big Is the Universe of Exons?

1990 • 228 citations

Molecular analysis of the alcohol dehydrogenase (Adhl) gene of maize

1984 • 207 citations

The genealogy of some recently evolved vertebrate proteins

1985 • 179 citations

Modular exchange principles in proteins

1991 • 169 citations

Molecular biology: Exons — present from the beginning?

1983 • 156 citations

Modular structural units, exons, and function in chicken lysozyme.

1983 • 147 citations

Intron/exon structure of the chicken pyruvate kinase gene

1985 • 144 citations

On the ancient nature of introns

1993 • 140 citations

Molecular analysis of the human class I alcohol dehydrogenase gene family and nucleotide sequence of the gene encoding the beta subunit.

1986 • 139 citations

Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain.

1985 • 116 citations

Comparison of the cis-acting control regions of two coordinately controlled genes involved in ethanol utilization in Aspergillus nidulans

1987 • 112 citations

Five identical intron positions in ancient duplicated genes of eubacterial origin

1994 • 110 citations

Nuclear genes encoding chloroplast hemoglobins in the unicellular green alga Chlamydomonas eugametos

1994 • 90 citations

Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase

1987 • 78 citations

Intron-dependent evolution of chicken glyceraldehyde phosphate dehydrogenase gene

1985 • 75 citations

Goose-type lysozyme gene of the chicken: sequence, genomic organization and expression reveals major differences to chicken-type lysozyme gene

1991 • 73 citations

Exons – original building blocks of proteins?

1991 • 72 citations

Protein Architecture and the Origin of Introns

1987 • 67 citations

Genetic engineering in the Precambrian: structure of the chicken triosephosphate isomerase gene.

1985 • 64 citations

Intron-dependent evolution of the nucleotide-binding domains within alcohol dehydrogenase and related enzymes

1986 • 50 citations

A novel intron site in the triosephosphate isomerase gene from the mosquito Culex tarsalis

1993 • 49 citations

Structure and expression of the rat class I alcohol dehydrogenase gene

1989 • 45 citations

The Origin and Function of Intervening Sequences in DNA: A Review

1987 • 40 citations

A general model for the evolution of nuclear pre-mRNA introns

1989 • 29 citations

Slippery introns and globin gene evolution

1993 • 28 citations

Structure of the Aspergillus nidulans pyruvate kinase gene

1988 • 25 citations

Structure of the gene encoding potato cytosolic pyruvate kinase

1992 • 17 citations

A commentary on: ‘Unexpected intron location in non‐vertebrate globin genes’, by: Moens et al. (FEBS Letters, 312 (1992) 105‐109) (FEBS 12294)

1993 • 6 citations

Commentary response

1993 • 4 citations