Deregulated Expression of the Homeobox Gene Cux-1 in Transgenic Mice Results in Downregulation of p27kip1 Expression during Nephrogenesis, Glomerular Abnormalities, and Multiorgan Hyperplasia

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

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1986 • 4,548 citations

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1995 • 3,267 citations

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1995 • 3,258 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Hox genes in vertebrate development

1994 • 2,057 citations

WT-1 is required for early kidney development

1993 • 1,976 citations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

1996 • 1,583 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27

1996 • 1,283 citations

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1996 • 1,208 citations

Defects in enteric innervation and kidney development in mice lacking GDNF

1996 • 1,169 citations

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

1995 • 1,118 citations

Functional identity of proliferating cell nuclear antigen and a DNA polymerase-δ auxiliary protein

1987 • 1,074 citations

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

1994 • 1,056 citations

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

1995 • 1,021 citations

Organogenesis of the kidney

1987 • 904 citations

Pax-2 controls multiple steps of urogenital development

1995 • 865 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

1994 • 657 citations

Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.

1994 • 607 citations

Hepatocyte Nuclear Factor 1 Inactivation Results in Hepatic Dysfunction, Phenylketonuria, and Renal Fanconi Syndrome

1996 • 574 citations

Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system

1990 • 562 citations

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

1995 • 561 citations

Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.

1996 • 493 citations

Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle

1994 • 460 citations

Functional Analysis of the Transforming Growth Factor βResponsive Elements in the WAF1/Cip1/p21 Promoter

1995 • 440 citations

The house mouse. Development and normal stages from fertilization to 4 weeks of age.

1972 • 413 citations

CDK inhibitors p18^INK4c and p27^Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

1998 • 399 citations

Inductive interaction in the development of the mouse metanephros

1955 • 393 citations

The basic-helix-loop-helix protein Pod1 is critically important for kidney and lung organogenesis

1999 • 362 citations

NHE3: a Na+/H+ exchanger isoform of renal brush border

1993 • 345 citations

Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips

1996 • 312 citations

The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype

1993 • 290 citations

Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities

1993 • 284 citations

CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.

1991 • 274 citations

Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure.

1998 • 265 citations

Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation, cell growth and development

2001 • 235 citations

Differentiation of epithelial foot processes and filtration slits: sequential appearance of occluding junctions, epithelial polyanion, and slit membranes in developing glomeruli.

1978 • 223 citations

Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut

1992 • 222 citations

c-myc as an inducer of polycystic kidney disease in transgenic mice

1991 • 210 citations

The molecular basis of embryonic kidney development

1997 • 191 citations

Cloning, embryonic expression, and alternative splicing of a murine kidney-specific Na-K-Cl cotransporter

1995 • 177 citations

The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase

1998 • 152 citations

p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice

1999 • 145 citations

Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis

1997 • 145 citations

Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1

1999 • 139 citations

The Human Cut Homeodomain Protein Can Repress Gene Expression by Two Distinct Mechanisms: Active Repression and Competition for Binding Site Occupancy

1996 • 129 citations

CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2F.

1996 • 118 citations

Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development

1999 • 118 citations

The Matrix Attachment Region-Binding Protein SATB1 Participates in Negative Regulation of Tissue-Specific Gene Expression

1997 • 117 citations

Regulatory molecules in kidney development

2000 • 115 citations

Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development

1992 • 111 citations

Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis

1996 • 109 citations

Cloning and Kidney Cell-specific Activity of the Promoter of the Murine Renal Na-K-Cl Cotransporter Gene

1996 • 105 citations

Transforming growth factor-beta1 up-regulates p15, p21 and p27 and blocks cell cycling in G1 in human prostate epithelium

1999 • 103 citations

Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer

1994 • 98 citations

The human cut homeodomain protein represses transcription from the c-myc promoter.

1994 • 95 citations

Contrasting expression patterns of three members of the myc family of protooncogenes in the developing and adult mouse kidney.

1991 • 93 citations

Interaction of the Nuclear Matrix-associated Region (MAR)-Binding Proteins, SATB1 and CDP/Cux, with a MAR Element (L2a) in an Upstream Regulatory Region of the Mouse CD8a Gene

1997 • 85 citations

Expression of a cut-related homeobox gene in developing and polycystic mouse kidney

1996 • 80 citations

Molecular cloning and characterization of the human p27^Kip1 gene promoter¹

1997 • 72 citations

Temporal patterns of gene expression of G1-S cyclins and cdks during the first and second mitotic cell cycles in mouse embryos

1996 • 71 citations

Expression of the cyclin kinase inhibitor, p27kip, in developing and mature human kidney

1998 • 65 citations

Characterization of the murine cyclin-dependent kinase inhibitor gene p27Kip1

1996 • 65 citations

Downregulation of cyclin-dependent kinase inhibitors p21 and p27 in pressure-overload hypertrophy

1997 • 60 citations

The protein CDP, but not CP1, footprints on the CCAAT region of the γ-globin gene in unfractionated B-cell extracts

1989 • 54 citations

Expression of the v-Src oncoprotein in fibroblasts disrupts normal regulation of the CDK inhibitor p27 and inhibits quiescence

1998 • 52 citations

CASP, a novel, highly conserved alternative-splicing product of the CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and interacts with full-length CDP in vitro

1997 • 44 citations

A Unique Variant of a Homeobox Gene Related to Drosophila cut is Expressed in Mouse Testis1

1996 • 37 citations

Molecular characterization of the cyclin-dependent kinase inhibitor p27 promoter

1997 • 33 citations

Cux-1 transgenic mice develop glomerulosclerosis and interstitial fibrosis

2003 • 31 citations

Development of the tubular nephron.

1995 • 30 citations

Cux/CDP homeodomain protein binds to an enhancer in the rat c-mos locus and represses its activity

1997 • 30 citations

Antisense oligonucleotides to Cux-1, a Cut-related homeobox gene, cause increased apoptosis in mouse embryonic kidney cultures.

1997 • 29 citations

The Human Cut Homeodomain Protein Represses Transcription from the c-myc Promoter

1994 • 22 citations

Quantitation and localization of laminin A, B1, and B2 chain RNA transcripts in developing kidney

1993 • 22 citations

Lectin characterization of cystogenesis in the SBM transgenic model of polycystic kidney disease.

1992 • 20 citations

Reduced expression of the CDK inhibitor p27KIP1 in rat two-stage bladder carcinogenesis and its association with expression profiles of p21WAF1/Cip1 and p53

1999 • 11 citations