Prostaglandin synthase-mediated metabolism of carcinogens and a potential role for peroxyl radicals as reactive intermediates.

On the function and mechanism of action of peroxidases

1976 • 1,017 citations

Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

1974 • 1,004 citations

Oxy-Radicals and Related Species: Their Formation, Lifetimes, and Reactions

1986 • 958 citations

Isolation and properties of intermediates in prostaglandin biosynthesis

1973 • 796 citations

Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1976 • 668 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

1988 • 604 citations

Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme.

1976 • 435 citations

Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).

1988 • 431 citations

Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands

1977 • 421 citations

Regulation of fibroblast cyclooxygenase synthesis by interleukin-1.

1988 • 401 citations

Mechanisms for the autoxidation of polyunsaturated lipids

1986 • 399 citations

Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1979 • 375 citations

Phospholipid precursors of prostaglandins

1968 • 333 citations

Prophylaxis of chemically induced benign and malignant epithelial tumors by vitamin A acid (retinoic acid)

1972 • 304 citations

Higher oxidation states of prostaglandin H synthase

1988 • 284 citations

Oxygenation of Unsaturated Fatty Acids by the Vesicular Gland of Sheep

1967 • 279 citations

Unequivocal demonstration that malondialdehyde is a mutagen

1983 • 269 citations

Peroxyl free radicals: potential mediators of tumor initiation and promotion

1987 • 269 citations

Comparative aspects of prostaglandin biosynthesis in animal tissues

1972 • 266 citations

Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases.

1989 • 235 citations

Free radical autoxidations of hydrocarbons

1968 • 231 citations

Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities.

1987 • 217 citations

Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence

1988 • 217 citations

Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland.

1975 • 209 citations

Conversion of linoleic acid hydroperoxide to hydroxy, keto, epoxyhydroxy, and trihydroxy fatty acids by hematin.

1985 • 197 citations

Interleukin 1 and tumor necrosis factor synergistically stimulate prostaglandin synthesis and phospholipase A2 release from rat renal mesangial cells

1989 • 193 citations

Subcellular localization of prostaglandin-forming cyclooxygenase in Swiss mouse 3T3 fibroblasts by electron microscopic immunocytochemistry.

1980 • 174 citations

Prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. Inactivation and activation by heme and other metalloporphyrins.

1978 • 167 citations

Metabolism of Polycyclic Aromatic Hydrocarbon Derivatives to Ultimate Carcinogens During Lipid Peroxidation

1983 • 162 citations

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis by vitamin A analogs (retinoids).

1978 • 160 citations

The action of prostaglandin synthetase on 2-arachidonyl-lecithin

1968 • 160 citations

Spectral properties of the higher oxidation states of prostaglandin H synthase.

1985 • 159 citations

Epidermal growth factor stimulation of prostaglandin E2 biosynthesis in amnion cells. Induction of prostaglandin H2 synthase.

1988 • 135 citations

Stimulation of de novo synthesis of prostaglandin G/H synthase in human endothelial cells by phorbol ester.

1988 • 132 citations

Isolation and covalent structure of the aspirin-modified, active-site region of prostaglandin synthetase

1983 • 126 citations

Oxidation reactions by prostaglandin cyclooxygenase-hydroperoxidase.

1981 • 124 citations

Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion)

1989 • 121 citations

Corticosteroids suppress cyclooxygenase messenger RNA levels and prostanoid synthesis in cultured vascular cells

1988 • 119 citations

Prostaglandin H synthase. Stoichiometry of heme cofactor.

1984 • 118 citations

Prostaglandin synthetase dependent activation of 7,8-dihydro-7,8-dihydroxy-benzo(a)pyrene to mutagenic derivatives

1978 • 117 citations

Bimodal distribution of the prostaglandin I2 synthase antigen in smooth muscle cells.

1983 • 99 citations

Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom.

1984 • 98 citations

Restoration of prostacyclin synthase in vascular smooth muscle cells after aspirin treatment: regulation by epidermal growth factor.

1985 • 98 citations

Hematin-catalyzed epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by polyunsaturated fatty acid hydroperoxides.

1985 • 90 citations

The formation of aminopyrine cation radical by the peroxidase activity of prostaglandin H synthase and subsequent reactions of the radical.

1985 • 88 citations

Activation of some aromatic amines to mutagenic products by prostaglandin endoperoxide synthetase.

1983 • 85 citations

Inhibition of liver microsomal lipid peroxidation by 13-cis-retinoic acid

1990 • 78 citations

Prostaglandin H synthase-dependent epoxidation of aflatoxin B₁

1985 • 75 citations

Mechanism of oxygen transfer by prostaglandin hydroperoxidase.

1980 • 73 citations

Prostaglandin H synthase-dependent mutagenic activation of heterocyclic aromatic amines of the IQ-type

1987 • 72 citations

The heme-binding properties of prostaglandin synthetase from sheep vesicular gland.

1981 • 71 citations

Inhibitors of protein and RNA synthesis cause a rapid block in prostaglandin production at the prostaglandin synthase step.

1986 • 70 citations

Arachidonic acid‐dependent metabolism of 7,8‐dihydroxy‐7,8‐dihydrobenzo[a]pyrene by ram seminal vesicles

1979 • 69 citations

Determination of the structure of the carbohydrate chains of prostaglandin endoperoxide synthase from sheep

2008 • 69 citations

Oxidation of (+)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by mouse keratinocytes: evidence for peroxyl radical- and monoxygenase-dependent metabolism

1986 • 67 citations

Oxy-Radicals and Related Species: Their Formation, Lifetimes, and Reactions

1986 • 63 citations

Involvement of prostaglandin synthetase in the peroxidative metabolism of diethylstilbestrol in Syrian hamster embryo fibroblast cell cultures.

1983 • 63 citations

Epoxidation of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene during (bi)sulfite autoxidation: activation of a procarcinogen by a cocarcinogen.

1986 • 61 citations

Phenylbutazone-dependent epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene. A new mechanism for prostaglandin H synthase-catalyzed oxidations.

1984 • 56 citations

Hydroperoxide-dependent cooxidation of 13-cis-retinoic acid by prostaglandin H synthase.

1987 • 55 citations

Arachidonic acid‐dependent metabolism of (±) trans‐7,8‐dihydroxy‐7,8‐ dihydro‐benzo[a]pyrene (BP‐7,8 diol) to 7,10/8,9 tetrols

1979 • 55 citations

Functional differentiation of cyclooxygenase and peroxidase activities of prostaglandin synthase by trypsin treatment. Possible location of a prosthetic heme binding site.

1988 • 49 citations

[9] Purification of PGH synthase from sheep vesicular glands

1982 • 41 citations

Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: A unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds

1989 • 40 citations

Peroxyl radical- and cytochrome P-450-dependent metabolic activation of (+)-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in mouse skin in vitro and in vivo.

1989 • 38 citations

Hydroperoxide-Dependent Oxidations during Prostaglandin Biosynthesis

1984 • 36 citations

Arachidonic acid-dependent metabolism of (±)-7,8-dihydroxy-7,8-dihydrobenzo[A]pyrene to polyguanylic acid-binding derivatives

1981 • 35 citations

Formation of unique arylamine:DNA adducts from 2-aminofluorene activated by prostaglandin H synthase.

1985 • 33 citations

Prostaglandin endoperoxide synthetase-dependent cooxidation of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in C3H/10T 1/2 clone 8 cells.

1982 • 31 citations

Purification of prostaglandin H synthetase and a fluorometric assay for its activity

1985 • 29 citations

EPR titration of ovine prostaglandin H synthase with hemin

1984 • 29 citations

Prostaglandin hydroperoxidase-dependent oxidation of phenylbutazone: relationship to inhibition of prostaglandin cyclooxygenase.

1988 • 26 citations

Prostaglandin H synthase-dependent co-oxygenation of (±)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in hamster trachea and human bronchus explants

1984 • 26 citations

Arachidonic Acid Metabolism and Tumor Initiation

1985 • 23 citations

Identification of the N-acetylcysteine conjugate of benzidine formed in the peroxidase activation system

1985 • 23 citations

The formation of 2‐aminofluorene‐dna adducts in vivo: Evidence for peroxidase‐mediated activation

1989 • 23 citations

Arachidonic Acid Metabolism and Tumor Initiation

1985 • 22 citations

Mechanism of xenobiotic cooxygenation coupled to prostaglandin H2 biosynthesis.

1980 • 22 citations

Reducing substrate activity of some aromatic amines for prostaglandin H synthase

1987 • 20 citations

[8] Purification and assay of PGH synthase from bovine seminal vesicles

1982 • 19 citations

Arachidonic Acid-Dependent Metabolism of Chemical Carcinogens and Toxicants

1985 • 18 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence

1988 • 18 citations

[43] Detection of the metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation

1984 • 17 citations

Contrasting disposition and metabolism of topically applied benzo(a)pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in mouse epidermis in vivo.

1987 • 15 citations

Prostaglandin Synthase-Dependent Cooxidation and Aromatic Amine Carcinogenesis

1985 • 13 citations

Phospholipases and prostaglandins

1978 • 12 citations

Hydroperoxide-dependent epoxidation of 3,4-dihydroxy-3,4-dihydrobenzo[a]anthracene by ram seminal vesicle microsomes and by hematin

1986 • 12 citations

Prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. Inactivation and activation by heme and other metalloporphyrins

1978 • 3 citations