Prostaglandin synthetase dependent activation of 7,8-dihydro-7,8-dihydroxy-benzo(a)pyrene to mutagenic derivatives

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

1974 • 1,144 citations

Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1976 • 668 citations

Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.

1976 • 316 citations

Metabolic conversion of benzo[a]pyrene by Syrian hamster liver microsomes and binding of metabolites to deoxyribonucleic acid

1973 • 315 citations

Structures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants

1977 • 299 citations

Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice.

1978 • 239 citations

High mutagenicity and toxicity of a diol epoxide derived from benzo[a]pyrene

1976 • 188 citations

Mutagenicity of non-K-region diols and diol-epoxides of benz(a)anthracene and benzo(a)pyrene in S. typhimurium TA 100

1975 • 168 citations

Benzo[a]pyrene diol epoxide covalently binds to deoxyguanosine and deoxyadenosine in DNA

1977 • 146 citations

Mutagenicity of metabolically activated benzo[a]anthracene 3,4-dihydrodiol: Evidence for bay region activation of carcinogenic polycyclic hydrocarbons

1976 • 96 citations

Prostagland in synthetase dependent benzo(a)pyrene oxidation: Products of the oxidation and inhibition of their formation by antioxidants

1977 • 91 citations

High microsome-mediated mutagenicity of the 3,4-dihydrodiol of 7-methylbenz[a]anthracene in S. typhimurium TA 98

1977 • 74 citations

High mutagenicity of metabolically activated chrysene 1,2 dihydrodiol: Evidence for bay region activation of chrysene

1977 • 66 citations

Stimulation of prostaglandin biosynthesis by lipoic acid

1977 • 37 citations

Chemical Carcinogenesis. Part A.

1974 • 35 citations