Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1999 • 1,044 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Pharmacological Rescue of Mutant p53 Conformation and Function

1999 • 794 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

2000 • 412 citations

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1997 • 346 citations

Activation of the cryptic DNA binding function of mutant forms of p53

1993 • 190 citations

p53 gene mutation: software and database

1996 • 189 citations

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

2000 • 174 citations

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

1998 • 161 citations

p53 gene mutation: software and database

1998 • 144 citations

Reactivation of Mutant p53 through Interaction of a C-Terminal Peptide with the Core Domain

1999 • 138 citations

Conformational and Molecular Basis for Induction of Apoptosis by a p53 C-terminal Peptide in Human Cancer Cells

1999 • 114 citations

Regulation of Mutant p53 Temperature-sensitive DNA Binding

1996 • 99 citations

Allosteric Regulation of the Thermostability and DNA Binding Activity of Human p53 by Specific Interacting Proteins

1996 • 95 citations

Structure–based rescue of common tumor–derived p53 mutants

1996 • 90 citations

Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

1998 • 86 citations

Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53.

1995 • 85 citations

p53-Induced Apoptosis as a Safeguard against Cancer

1999 • 81 citations

Immunolocalization of Human p14ARF to the Granular Component of the Interphase Nucleolus

2000 • 78 citations

Mutant p53 detected in a majority of Burkitt lymphoma cell lines by monoclonal antibody PAb240.

1991 • 74 citations

The single-stranded DNA end binding site of p53 coincides with the C- terminal regulatory region

1996 • 64 citations

Reactivation of mutant p53: a new strategy for cancer therapy

1998 • 62 citations

Biochemical characterization of different conformational states of the Sf9 cell‐purified p53His175 mutant protein

1999 • 13 citations

Functional Rescue of Mutant p53 as a Strategy to Combat Cancer

2002 • 3 citations