Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms

1995 • 533 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

1996 • 459 citations

Small peptides activate the latent sequence-specific DNA binding function of p53

1995 • 444 citations

p53 Transcriptional Activation Mediated by Coactivators TAF _II 40 and TAF _II 60

1995 • 438 citations

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.

1994 • 377 citations

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

1995 • 347 citations

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1997 • 346 citations

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

1995 • 334 citations

Allosteric activation of latent p53 tetramers

1994 • 302 citations

High-Resolution Structure of the Oligomerization Domain of p53 by Multidimensional NMR

1994 • 300 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1996 • 280 citations

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

1993 • 263 citations

p53 domains: identification and characterization of two autonomous DNA-binding regions.

1993 • 239 citations

Mutant conformation of p53

1992 • 214 citations

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

1993 • 206 citations

Wild-type p53 adopts a ‘mutant’-like conformation when bound to DNA.

1993 • 199 citations

Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases

1995 • 199 citations

Activation of the cryptic DNA binding function of mutant forms of p53

1993 • 190 citations

Post-translational modification of p53.

1994 • 140 citations

Precise epitope mapping of the murine transformation-associated protein, p53.

1985 • 139 citations

The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding.

1995 • 126 citations

A proline-rich motif in p53 is required for transactivation- independent growth arrest as induced by Gas1

1997 • 91 citations

Restoration of the transcription activation function to mutant p53 in human cancer cells.

1996 • 66 citations

Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation.

1995 • 55 citations

An engineered four-stranded coiled coil substitutes for the tetramerization domain of wild-type p53 and alleviates transdominant inhibition by tumor-derived p53 mutants.

1996 • 53 citations

On the regulation of the p53 tumour suppressor, and its role in the cellular response to DNA damage

1995 • 47 citations

A novel p53 germline alteration identified in a late onset breast cancer kindred.

1996 • 33 citations

PAK1, a gene that can regulate p53 activity in yeast.

1995 • 30 citations