Heterogeneity of liver microsomal cytochrome P-450: The spectral characterization of reactants with reduced cytochrome P-450

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

1949 • 16,078 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Spectral studies of drug interaction with hepatic microsomal cytochrome.

1967 • 1,126 citations

Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions

1971 • 559 citations

Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs.

1960 • 511 citations

Microsomes and Drug Oxidations

1970 • 463 citations

Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats

1966 • 418 citations

Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

1972 • 350 citations

Drug interaction with hepatic microsomal cytochrome.

1966 • 335 citations

Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene

1967 • 334 citations

Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.

1969 • 275 citations

A new spectral intermediate associated with cytochrome P-450 function in liver microsomes

1971 • 240 citations

Existence and Separation of Three Forms of Cytochrome P-450 from Rat Liver Microsomes

1973 • 221 citations

Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

1973 • 208 citations

Multiplicity of cytochrome P450 hemoproteins in rat liver microsomes

1974 • 200 citations

Substrate interaction with hydroxylase system in liver microsomes

1966 • 183 citations

Binding of¹⁴C-Carbon Tetrachloride to Microsomal Proteinsin vitroand Formation of CHCl₃by Reduced Liver Microsomes

1973 • 177 citations

Nature of the type I and II spectral changes in liver microsomes

1970 • 172 citations

Gel electrophoresis of partially purified cytochromes P450 from liver microsomes of variously-treated rats

1973 • 136 citations

Evidence for two forms of P-450 hemoprotein in microsomal membranes

1966 • 136 citations

The Enzymic Formation of a Methylenedioxyphenyl Derivative Exhibiting an Isocyanide-like Spectrum with Reduced Cytochrome P-450 in Hepatic Microsomes

1971 • 134 citations

Studies on the Kinetics of Cytochrome P-450 Reduction in Rat Liver Microsomes

1970 • 123 citations

Diethylaminoethyl 2,2-diphenylvalerate HCl (SKF 525-A)—In vivo and in vitro effects of metabolism by rat liver microsomes—Formation of an oxygenated complex

1972 • 118 citations

Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital.

1969 • 111 citations

A cytochrome P-450-piperonyl butoxide spectrum similar to that produced by ethyl isocyanide

1971 • 108 citations

Sex-dependent differences in drug metabolism in the rat. I. Temporal changes in microsomal drug-metabolizing system of the liver during sexual maturation.

1974 • 100 citations

Metyrapone interaction with hepatic microsomal cytochrome P-450 from rats treated with phenobarbital

1969 • 98 citations

CARBON MONOXIDE BONDING IN HEMEPROTEINS *

1970 • 97 citations

The production and modification of cytochrome P-450 difference spectra by in vivo administration of methylenedioxyphenyl compounds

1972 • 89 citations

Metyrapone interaction with Pseudomonas putida cytochrome P-450

1971 • 88 citations

Inhibition of hepatic oxidative xenobiotic metabolism by piperonyl butoxide

1972 • 78 citations

Formation and binding of carbanions by cytochrome P-450 of liver microsomes.

1973 • 75 citations

Metabolism and Cytochrome P-450 Binding Spectra of (+)- and (—)-Hexobarbital in Rat Liver Microsomes

1969 • 64 citations

EPR measurements of substrate interaction with cytochrome P-450

1966 • 55 citations

Influence of pyridine and some pyridine derivatives on spectral properties of reduced microsomes and on microsomal drug metabolizing activity

1974 • 50 citations

Induction of drug metabolism. 3. Further information of a new P-450 hemoprotein after treatment of rats with 3-methylcholanthrene.

1969 • 48 citations

Studies on the molecular function of cytochrome P-450 during drug metabolism.

1973 • 47 citations

The effect of piperonyl butoxide concentration on the formation of cytochrome P-450 difference spectra in hepatic microsomes from mice.

1972 • 45 citations

Complexes of Metabolites of Amphetamines with Hepatic Cytochrome P-450

1974 • 44 citations

Evidence for an inhibitory product · cytochrome P-450 complex generated during benzphetamine metabolism by liver microsomes

1973 • 43 citations

Induction of a new hepatic microsomal haemoprotein by safrole and isosafrole

1971 • 42 citations

DRUGS, ALCOHOL AND SEX HORMONES: A MOLECULAR PERSPECTIVE OF THE RECEPTIVITY OF CYTOCHROME P‐450*

1973 • 38 citations

Effect of synergists on drug metabolism.

1973 • 36 citations

The influence of cytochrome P-450 induction on the metabolic formation of 455-NM complexes from amphetamines.

1974 • 36 citations

The formation of complexes absorbing at 455 nm from cytochrome P-450 and metabloites of compounds related to SKF 525-A.

1974 • 35 citations

The differentiation of rat liver endoplasmic reticulum membranes: Apo-cytochrome P450 as a membrane protein

1973 • 35 citations

A comparison of some properties of microsomal cytochrome P-450 from normal, methylcholanthrene-, and phenobarbital-treated rats

1971 • 34 citations

A study of some possible mechanisms by which magnesium activates hepatic microsomal drug metabolism in vitro.

1970 • 32 citations

Ethyl isocyanide complexes of bacterial cytochrome P-450

1971 • 32 citations

Formation and ligand binding of the fluorenyl carbanion by hepatic cytochrome P450

1973 • 30 citations

Piperonyl Butoxide Metabolism by Cytochrome P-450: Factors Affecting the Formation and Disappearance of the Metabolite-Cytochrome P-450 Complex

1972 • 24 citations

Effects of extraction with isooctane upon the properties of liver microsomes.

1971 • 24 citations

Effect of Phenobarbital and_3,4-Benzpyrene Treatment of Rats on the Microsomal Binding and Hydroxylation of Nortriptyline and Desmethyl-imipramine: Evidence for Qualitative Changes in Cytochrome P-450-Ligand Interaction following Phenobarbital Pretreatment

1972 • 22 citations

Inhibition of the Metabolism ofN-Substituted Amphetamines by SKF 525-A and Related Compounds

1974 • 20 citations

Formation Rates of the Two Ethyl Isocyanide Compounds of Liver Cytochrome P-450 at Low Temperatures

1971 • 18 citations

The interaction of various N‐substituted amphetamines with cytochrome P‐450 of rabbit liver microsomes

1973 • 17 citations