Evidence in Rat and Mouse Liver for Temporal Control of Two Forms of Cytochrome P-450 Inducible by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Biological Reactive Intermediates

1977 • 597 citations

Organization, Transcription, and Regulation in the Animal Genome

1973 • 454 citations

Aryl hydrocarbon (benzo[a]pyrene) hydroxylase in microsomes from rat tissues: Differential inhibition and stimulation by benzoflavones and organic solvents

1971 • 374 citations

Determination of drug metabolizing enzymes in needle biopsies of human liver

1972 • 332 citations

Closure of the Secondary Palate in Three Strains of Mice

1956 • 273 citations

Induction of multiple forms of mouse liver cytochrome P-450. Evidence for genetically controlled de novo protein synthesis in response to treatment with beta-naphthoflavone or phenobarbital.

1976 • 229 citations

The Ah Locus and the Metabolism of Chemical Carcinogens and Other Foreign Compounds

1977 • 188 citations

Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro.

1972 • 180 citations

Ontogenetic expression of polycyclic aromatic compound-inducible monooxygenase activities and forms of cytochrome P-450 in rabbit. Evidence for temporal control and organ specificity of two genetic regulatory systems.

1977 • 164 citations

Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice. Co-segregation with aryl hydrocarbon (benzo(alpha)pyrene) hydroxylase induction.

1977 • 155 citations

Immunochemical evidence for six forms of rat liver cytochrome P450 obtained using antibodies against purified rat liver cytochromes P450 and P448.

1976 • 133 citations

Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse.

1977 • 109 citations

Amino-terminal sequence of phenobarbital-inducible cytochrome P-450 from rabbit liver microsomes: Similarity to hydrophobic amino-terminal segments of preproteins

1977 • 104 citations

Cytosolic receptor for aryl hydrocarbon hydroxylase induction by polycyclic aromatic compounds. Evidence for structural and regulatory variants among established cell cultured lines.

1977 • 96 citations

Genetic Regulation of Aryl Hydrocarbon Hydroxylase Induction

1973 • 93 citations

Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450.

1975 • 84 citations

Multiplicity of cytochrome P-450 hemoproteins in rat liver microsomes. Preparation and specificity of an antibody to the hemoprotein induced by phenobarbital.

1975 • 81 citations

Accessibility of cytochrome P450 in microsomal membranes: inhibition of metabolism by antibodies to cytochrome P450.

1977 • 75 citations

THE GENETIC CONTROL OF ENZYME ACTIVITY DURING DIFFERENTIATION

1961 • 69 citations

A genetic locus affecting the developmental expression of an enzyme in Drosophila melanogaster

1975 • 68 citations

GENETIC STUDIES ON MUTANT ENZYMES IN MAIZE. III. CONTROL OF GENE ACTION IN THE SYNTHESIS OF pH 7.5 ESTERASE

1962 • 66 citations

Genetic determination of the α-galactosidase developmental program in mice

1975 • 63 citations

Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse.

1973 • 59 citations

Genetic association of increases in naphthalene, acetanilide, and biphenyl hydroxylations with inducible aryl hydrocarbon hydroxylase in mice

1976 • 57 citations

Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus

1977 • 51 citations

Differential induction of murine Ah locus-associated monooxygenase activities in rabbit liver and kidney

1975 • 45 citations

A model for genetic analysis of programmed gene expression as reflected in the development of membrane antigens

1975 • 36 citations

A method for the purification and reconcentration of nucleic acids eluted or extracted from polyacrylamide gels

1973 • 24 citations

A simple radiometric assay for microsomal aryl hydroxylase activity

1970 • 23 citations

Role of sulfhydryl groups in the hydroxylation of benzo[a]pyrene by purified rat and rabbit cytochrome P-448

1977 • 16 citations

THE MURINE Ah LOCUS AND DYSMORPHOGENESIS

1977 • 15 citations