The resolution and reconstitution of the liver microsomal hydroxylation system

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The colorimetric estimation of formaldehyde by means of the Hantzsch reaction

1953 • 4,357 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies

1962 • 1,431 citations

Spectral studies of drug interaction with hepatic microsomal cytochrome.

1967 • 1,126 citations

Microsomal Triphosphopyridine Nucleotide-Cytochrome c Reductase of Liver

1962 • 909 citations

A simple procedure for removal of triton X-100 from protein samples

1973 • 857 citations

Pigments of rat liver microsomes

1958 • 634 citations

Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes

1968 • 625 citations

Oxidases and Related Redox Systems

1975 • 596 citations

Resolution of the Cytochrome P-450-containing ω-Hydroxylation System of Liver Microsomes into Three Components

1969 • 573 citations

Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions

1971 • 559 citations

[92] The preparation and properties of microsomal TPNH-cytochrome c reductase from pig liver

1967 • 558 citations

Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems

1965 • 503 citations

Turnover of Constituents of the Endoplasmic Reticulum Membranes of Rat Hepatocytes

1967 • 484 citations

Microsomes and Drug Oxidations

1970 • 463 citations

Phosphatidylcholine Requirement in the Enzymatic Reduction of Hemoprotein P-450 and in Fatty Acid, Hydrocarbon, and Drug Hydroxylation

1970 • 462 citations

Microsomes and drug oxidation

1969 • 451 citations

Studies on pig liver microsomes. I. Enzymic and pigment composition of different microsomal fractions

1958 • 433 citations

Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats

1966 • 418 citations

Cytochrome P-450 and its Role in Drug Metabolism

1972 • 392 citations

Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase

1966 • 379 citations

Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic Reticulum

1966 • 357 citations

Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

1972 • 350 citations

A Form of Reduced Nicotinamide Adenine Dinucleotide-Cytochrome b5 Reductase Containing Both the Catalytic Site and an Additional Hydrophobic Membrane-binding Segment

1973 • 344 citations

Properties of hepatic reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase

1973 • 344 citations

Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene

1967 • 334 citations

Reconstitution of biological membranes

1972 • 315 citations

Reconstruction of biological membranes.

1972 • 289 citations

TRIPHOSPHOPYRIDINE NUCLEOTIDE-CYTOCHROME c REDUCTASE IN LIVER

1950 • 280 citations

Partial purification of cytochromes P-450 and P-448 from rat liver microsomes

1972 • 270 citations

Camphor binding by Pseudomonas putida cytochrome P-450

1971 • 262 citations

Components of the Electron Transport System in Adrenal Steroid Hydroxylase

1967 • 239 citations

Drugs and Enzyme Induction

1969 • 238 citations

The Roles of Putidaredoxin and P450cam in Methylene Hydroxylation

1972 • 223 citations

Existence and Separation of Three Forms of Cytochrome P-450 from Rat Liver Microsomes

1973 • 221 citations

Reconstitution of oxidate phophorylation

1972 • 216 citations

Reconstitution of oxidative phosphorylation.

1972 • 213 citations

Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

1973 • 208 citations

Studies on the Mechanism of Microsomal Triphosphopyridine Nucleotide-Cytochrome c Reductase

1965 • 201 citations

Studies on the electron-transport system XXVII. The respiratory activity of acetone-extracted beef-heart mitochondria role of coenzyme Q and other lipids

1961 • 196 citations

Biological hydroxylation mechanisms

1973 • 186 citations

Purification by Means of Detergents and Properties of Cytochrome b5 from Liver Microsomes

1968 • 185 citations

Substrate interaction with hydroxylase system in liver microsomes

1966 • 183 citations

Cytochrome P-450 from Bovine Adrenocortical Mitochondria: an Enzyme for the Side Chain Cleavage of Cholesterol

1973 • 155 citations

Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: Lipid requirement for drug demethylation

1969 • 152 citations

Conversion of P-450 to P-420 by neutral salts and some other reagents.

1967 • 150 citations

Preparation of Partially Purified, Lipid-depleted Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome c Reductase from Rat Liver Microsomes

1974 • 146 citations

Properties of a solubilized form of the cytochrome P-450-containing mixed-function oxidase of liver microsomes.

1970 • 138 citations

The Enzymatic Hydroxylation of n-Octane by Corynebacterium sp. Strain 7E1C

1970 • 135 citations

Conversion of P-450 to P-420 by Neutral Salts and some other Reagents

1967 • 132 citations

The Nature of the Flavin Binding in Microsomal Cytochrome b5 Reductase

1961 • 128 citations

Reconversion of detergent- and sulfhydryl reagent-produced P-420 to P-450 by polyols and glutathione

1967 • 123 citations

An Affinity Column Method for Partial Purification of Cytochrome P-450 from Phenobarbital-induced Rabbit Liver Microsomes

1974 • 118 citations

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates

1971 • 118 citations

Properties of a Yeast Cytochrome P‐450‐Containing Enzyme System which Catalyzes the Hydroxylation of Fatty Acids, Alkanes, and Drugs

1973 • 116 citations

The Nature of the Heme Binding in Microsomal Cytochrome b5

1960 • 113 citations

Studies of the electron-transfer system LXIV. Role of phospholipid in cytochrome oxidase

1965 • 102 citations

On the Hydroxylation of Cyclohexane in Rat Liver Microsomes

1969 • 101 citations

Microsomal electron transport reactions

1971 • 93 citations

Properties of cytochrome P-450 as affected by environmental factors: Qualitative changes due to administration of polycyclic hydrocarbons

1971 • 90 citations

Requirement of a new flavoprotein and a non-heme iron-containing protein in the steroid 11β- and 18-hydroxylase system

1966 • 88 citations

Microsomal electron transport reactions

1971 • 85 citations

Properties of a Submicrosomal Particle Containing P-450 and Flavoprotein

1968 • 84 citations

Composition and structure of camphor hydroxylase components and homology between putidaredoxin and adrenodoxin

1971 • 79 citations

Role of phospholipids in the hepatic microsomal drug-metabolizing system.

1970 • 78 citations

Microsomes and drug oxidations

1989 • 76 citations

Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide-dependent mixed-function oxidase system of hepatic microsomes. I. Effects of activation and inhibition of the fatty acyl coenzyme A desaturation system.

1973 • 74 citations

Crystalline cytochrome P-450cam

1970 • 73 citations

Partial purification and properties of cytochromes P-450 and P-448 from rat liver microsomes

1972 • 72 citations

A role for phospholipids in the binding and metabolism of drugs by hepatic microsomes. Use of the fluorescent hydrophobic probe 1-anilinonaphthalene-8-sulphonate

1971 • 68 citations

A reconstituted microsomal enzyme system that converts naphthalene to trans-1,2-dihydroxy-1,2-dihydronaphthalene via naphthalene-1,2-oxide: Presence of epoxide hydrase in cytochrome P-450 and P-448 fractions

1972 • 64 citations

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. 3. Properties of the reconstituted 3,4-benzypyrene hydroxylase system.

1972 • 63 citations

Differences in P-450 Cytochromes from Livers of Rats Treated with Phenobarbital and with 3-Methylcholanthrene

1973 • 61 citations

Sedimentation and other properties of the reconstituted liver microsomal mixed-function oxidase system containing cytochrome P-450, reduced triphosphopyridine nucleotide-cytochrome P-450 reductase, and phosphatidylcholine.

1973 • 57 citations

Effect of enzyme inducers on substrate specificity of the cytochrome P-450's.

1973 • 56 citations

A low-temperature EPR study of partially purified, soluble ferric cytochromes P-450 and P-448 from rat liver microsomes

1973 • 54 citations

Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide-dependent mixed-function oxidase system of hepatic microsomes. II. Role of the type I drug-binding site of cytochrome P-450.

1973 • 50 citations

Resolution and Reconstitution of the Mitochondrial Electron Transport System

1972 • 49 citations

Relationship between NADH and NADPH oxidation during drug metabolism.

1973 • 44 citations

Removal of nonionic detergents from proteins by chromatography on Sephadex LH-20

1969 • 43 citations

THE ROLE OF CYTOCHROME P‐450 AND P‐448 IN DRUG AND STEROID HYDROXYLATIONS

1973 • 41 citations

12α-Hydroxylation of 7α-hydroxy-4-cholesten-3-one by a reconstituted system from rat liver microsomes

1973 • 41 citations

Mechanism of cholestasis

1971 • 41 citations

The preparation of microsomal electron-transfer complexes

1967 • 40 citations

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates

1972 • 39 citations

Organic solvent extraction of liver microsomal lipid

1974 • 38 citations

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates

1972 • 37 citations

Electron Transport Components of Hepatic Microsomes

1973 • 35 citations

Preparation and physicochemical properties of functional hemoprotein P450 from mammalian tissue microsomes

1970 • 33 citations

A fatty acid gamma-hydroxylation system solubilized from porcine kidney cortex microsomes.

1971 • 33 citations

A fatty acid ω-hydroxylation system solubilized from porcine kidney cortex microsomes

1971 • 32 citations

Properties of partially purified liver microsomal cytochrome P‐450: Acceptance of two electrons during anaerobic titration

1974 • 32 citations

Partial purification and some spectral properties of hepatic microsomal cytochrome P-450.

1973 • 29 citations

The Characterization and Interconversions of Two Conformational States of Cytochrome b5 Reductase

1971 • 29 citations

Enzymatic solubilization of microsomal nadh-cytochrome b5 reductase by lysosomes

1968 • 28 citations

BIOCHEMICAL STUDIES ON CYTOCHROME P‐450 SOLUBILIZED FROM LIVER MICROSOMES: PARTIAL PURIFICATION AND MECHANISM OF CATALYSIS*

1973 • 27 citations

On the solubilization of NADPH-cytochrome c reductase from rat liver microsomes with crude pancreatic lipase

1972 • 27 citations

Characterization of partially purified cytochromes P-450 and P-448 from rat liver microsomes.

1973 • 26 citations

The molecular weight of NADPH-cytochrome C reductase isolated by immunoprecipitation from detergent-solubilized rat liver microsomes

1973 • 25 citations

Preparation and properties of a solubilized form of cytochrome P-450 from chick embryo liver microsomes.

1971 • 24 citations

Studies on P-450

1970 • 24 citations

Effects of extraction with isooctane upon the properties of liver microsomes.

1971 • 24 citations

Dechlorination of chloroethane with a reconstituted liver microsomal system

1973 • 22 citations

7α-Hydroxylation of taurodeoxycholic acid by a reconstituted system from rat liver microsomes

1973 • 14 citations

PREPARATION AND PROPERTIES OF MITOCHONDRIAL CYTOCHROME P-450 FROM BOVINE ADRENAL CORTEX

1973 • 11 citations

Is the liver cytochrome P-450-linked biotransformation system lecithin-dependent?

1972 • 10 citations

Effects of Triton X-100 on Drug Hydroxylation System of Rat Liver Microsomes Induced by Phenobarbital or 3-Methylcholanthrene

1972 • 8 citations

Chemistry of cytochrome P-450 purified from endocrine systems.

1973 • 7 citations

Inelastic laser light scattering and particle size of detergent-treated microsomes

1973 • 6 citations

Drug metabolism by an acetone powder from rat hepatic microsomes

1971 • 4 citations