Molecular Dissection of 2B4 Signaling: Implications for Signal Transduction by SLAM-Related Receptors

Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis

2001 • 1,728 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

1998 • 951 citations

Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

1998 • 759 citations

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

1998 • 500 citations

X-Linked Lymphoproliferative Disease

2000 • 470 citations

2B4, the Natural Killer and T Cell Immunoglobulin Superfamily Surface Protein, Is a Ligand for CD48

1998 • 405 citations

The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease

2003 • 325 citations

VAV proteins as signal integrators for multi-subunit immune-recognition receptors

2002 • 321 citations

Cutting Edge: Human 2B4, an Activating NK Cell Receptor, Recruits the Protein Tyrosine Phosphatase SHP-2 and the Adaptor Signaling Protein SAP

1999 • 308 citations

Gntb-A, a Novel Sh2d1a-Associated Surface Molecule Contributing to the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected B Cells in X-Linked Lymphoproliferative Disease

2001 • 306 citations

A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells.

1993 • 283 citations

SAP couples Fyn to SLAM immune receptors

2003 • 282 citations

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

2003 • 274 citations

Cutting Edge: Functional Requirement for SAP in 2B4-Mediated Activation of Human Natural Killer Cells as Revealed by the X-Linked Lymphoproliferative Syndrome

2000 • 263 citations

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

2001 • 258 citations

Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes.

1993 • 226 citations

Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells.

1993 • 206 citations

Identification of the 2B4 molecule as a counter-receptor for CD48.

1998 • 169 citations

Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity

2000 • 169 citations

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.

1992 • 151 citations

Cutting Edge: Defective NK Cell Activation in X-Linked Lymphoproliferative Disease

2000 • 150 citations

Cutting Edge: Identification of the 2B4 Molecule as a Counter-Receptor for CD48

1998 • 140 citations

Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells.

1999 • 128 citations

The SLAM family of immune-cell receptors

2003 • 119 citations

Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A

1999 • 109 citations

Molecular and Functional Characterization of Mouse Signaling Lymphocytic Activation Molecule (SLAM): Differential Expression and Responsiveness in Th1 and Th2 Cells

1999 • 109 citations

Cutting Edge: NK Cell Inhibitory Receptors Prevent Tyrosine Phosphorylation of the Activation Receptor 2B4 (CD244)

2000 • 105 citations

Molecular and immunological basis of X‐linked lymphoproliferative disease

2003 • 98 citations

Functional Dichotomy in Natural Killer Cell Signaling

2001 • 88 citations

Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells

2000 • 87 citations

Cutting Edge: The NK Cell Receptor 2B4 Augments Antigen-Specific T Cell Cytotoxicity Through CD48 Ligation on Neighboring T Cells

2003 • 82 citations

Cutting Edge: Regulation of CD8+ T Cell Proliferation by 2B4/CD48 Interactions

2001 • 80 citations

A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling

1998 • 75 citations

Lymphocytic vasculitis in X-linked lymphoproliferative disease

2001 • 69 citations

2B4 Is Constitutively Associated with Linker for the Activation of T Cells in Glycolipid-Enriched Microdomains: Properties Required for 2B4 Lytic Function

2002 • 49 citations

Association of the X-linked Lymphoproliferative Disease Gene Product SAP/SH2D1A with 2B4, a Natural Killer Cell-activating Molecule, Is Dependent on Phosphoinositide 3-Kinase

2002 • 47 citations