The role of glutamate in the regulation of bone mass and architecture.

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

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Regulation of bone formation by applied dynamic loads.

1984 • 1,533 citations

Regulation of bone mass by mechanical strain magnitude

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Improved Bone Structure and Strength After Long-Term Mechanical Loading Is Greatest if Loading Is Separated Into Short Bouts

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Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death

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The influence of strain rate on adaptive bone remodelling

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Morphological evidence of gap junctions between bone cells

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Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats

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Glutamate signalling in non-neuronal tissues

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Low‐Magnitude Mechanical Loading Becomes Osteogenic When Rest Is Inserted Between Each Load Cycle

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Glutamate Receptors Are Expressed by Bone Cells and Are Involved in Bone Resorption

1998 • 237 citations

Glutamate signaling in peripheral tissues

2003 • 233 citations

Mechanically regulated expression of a neural glutamate transporter in bone: A role for excitatory amino acids as osteotropic agents?

1997 • 214 citations

Osteocytes inhibit osteoclastic bone resorption through transforming growth factor‐β: Enhancement by estrogen*

2002 • 190 citations

Expression of an N-Methyl-D-Aspartate-Type Receptor by Human and Rat Osteoblasts and Osteoclasts Suggests a Novel Glutamate Signaling Pathway in Bone

1998 • 176 citations

Hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells: The effects of glutamate and protection by purines

2006 • 126 citations

Enabling bone formation in the aged skeleton via rest-inserted mechanical loading

2003 • 125 citations

Cell-to-cell interactions in bone

2004 • 118 citations

The glutamate receptor antagonist MK801 modulates bone resorptionin vitroby a mechanism predominantly involving osteoclast differentiation

1999 • 107 citations

Functional characterization of N-methyl-d-aspartic acid-gated channels in bone cells

1999 • 103 citations

Expression of Functional Metabotropic Glutamate Receptors in Primary Cultured Rat Osteoblasts

2000 • 94 citations

Evidence for targeted vesicular glutamate exocytosis in osteoblasts

2001 • 88 citations

Regulation of spontaneous glutamate release activity in osteoblastic cells and its role in differentiation and survival: evidence for intrinsic glutamatergic signaling in bone

2001 • 85 citations

Secretion of L-glutamate from osteoclasts through transcytosis

2006 • 85 citations

KYNURENINE PATHWAY METABOLISM IN PATIENTS WITH OSTEOPOROSIS AFTER 2 YEARS OF DRUG TREATMENT

2006 • 82 citations

Modulation of connexin43 alters expression of osteoblastic differentiation markers

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NMDA glutamate receptors are expressed by osteoclast precursors and involved in the regulation of osteoclastogenesis

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The high bone mass family--the role of Wnt/Lrp5 signaling in the regulation of bone mass.

2004 • 60 citations

Active NMDA glutamate receptors are expressed by mammalian osteoclasts

1999 • 60 citations

Megakaryocyte population in human bone marrow increases with estrogen treatment: a role in bone remodeling?

2000 • 60 citations

The NMDA Type Glutamate Receptors Expressed by Primary Rat Osteoblasts Have the Same Electrophysiological Characteristics as Neuronal Receptors

2002 • 58 citations

Mechanical loading modulates glutamate receptor subunit expression in bone

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Cytokines and Skeletal Physiology

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New mechanisms and targets in the treatment of bone fragility

2006 • 56 citations

Characterization of the glutametergic system in MG-63 osteoblast-like osteosarcoma cells.

2005 • 52 citations

Glutamate Does Not Play a Major Role in Controlling Bone Growth

2001 • 51 citations

Demonstration of expression of mRNA for particular AMPA and kainate receptor subunits in immature and mature cultured rat calvarial osteoblasts

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Down-regulation of N-methyl D-aspartate receptor in rat-modeled disuse osteopenia

2005 • 44 citations

Current perspectives on NMDA-type glutamate signalling in bone

2006 • 44 citations

Glutamate Suppresses Osteoclastogenesis through the Cystine/Glutamate Antiporter

2007 • 41 citations

Group III metabotropic glutamate receptor activation inhibits Ca²⁺ influx and nitric oxide synthase activity in bone marrow stromal cells

2005 • 39 citations

Effects of vitamin D3, 17β-estradiol, vasoactive intestinal peptide, and glutamate on electric coupling between rat osteoblast-like cells in vitro

1998 • 17 citations

Glutamate is a determinant of cellular proliferation through modulation of nuclear factor E2 p45‐related factor‐2 expression in osteoblastic MC3T3‐E1 cells

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Glutamatergic system in bone physiology.

2004 • 15 citations