The Sensation and Regulation of Interactions with the Extracellular Environment: The Cell Biology of Lymphocyte Adhesion Receptors

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

The Immunoglobulin Superfamily—Domains for Cell Surface Recognition

1988 • 2,237 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS

1963 • 1,947 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)

1987 • 1,712 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

1986 • 1,428 citations

Arg-Gly-Asp: A versatile cell recognition signal

1986 • 1,413 citations

Two distinct classes of carbohydrate-recognition domains in animal lectins.

1988 • 1,259 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

1989 • 1,135 citations

Neural Cell Adhesion Molecule: Structure, Immunoglobulin-Like Domains, Cell Surface Modulation, and Alternative RNA Splicing

1987 • 1,134 citations

Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.

1989 • 1,115 citations

The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System

1987 • 1,104 citations

Principles of protein structure

1980 • 1,094 citations

Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.

1988 • 988 citations

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families

1988 • 967 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes

1989 • 878 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

1986 • 854 citations

Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1

1989 • 837 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

Naive and memory T cells show distinct pathways of lymphocyte recirculation.

1990 • 792 citations

The Neural Cell Adhesion Molecule (NCAM) as a Regulator of Cell-Cell Interactions

1988 • 790 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus

1990 • 709 citations

An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2

1987 • 699 citations

Cell adhesion. Competition between nonspecific repulsion and specific bonding

1984 • 680 citations

Laminin receptor on platelets is the integrin VLA-6

1988 • 679 citations

An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion

1989 • 659 citations

Adhesion molecules controlling lymphocyte migration

1989 • 654 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM

1988 • 631 citations

Cell Adhesion Molecules in the Regulation of Animal Form and Tissue Pattern

1986 • 630 citations

Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration.

1988 • 626 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Amino acid sequence of the human fibronectin receptor.

1987 • 596 citations

The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.

1983 • 583 citations

Cloning of a lymphocyte homing receptor reveals a lectin domain

1989 • 522 citations

Cloning of the $beta; subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene family

1987 • 520 citations

Haptotaxis and the Mechanism of Cell Motility

1967 • 509 citations

Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α

1989 • 495 citations

The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester.

1986 • 487 citations

Antigen‐Driven Selection of Virgin and Memory B Cells

1986 • 476 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa.

1988 • 446 citations

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1988 • 445 citations

Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones

1986 • 437 citations

Mouse Lymph Node Homing Receptor cDNA Clone Encodes a Glycoprotein Revealing Tandem Interaction Domains

1989 • 428 citations

Growth Cone Guidance in Insects: Fasciclin II Is a Member of the Immunoglobulin Superfamily

1988 • 424 citations

The CD4 antigen: Physiological ligand and HIV receptor

1988 • 413 citations

Function and regulation of the neutrophil MEL-14 antigen in vivo: comparison with LFA-1 and MAC-1.

1989 • 413 citations

Localization of an Arg-Gly-Asp Recognition Site Within an Integrin Adhesion Receptor

1988 • 402 citations

Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells

1989 • 389 citations

Molecular Biology and Function of CD4 and CD8

1989 • 388 citations

Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein.

1987 • 376 citations

Effect of venous shear stress on CD18-mediated neutrophil adhesion to cultured endothelium

1990 • 370 citations

Endothelial cells use alpha 2 beta 1 integrin as a laminin receptor.

1989 • 363 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

A novel vitronectin receptor integrin (αvβx) is responsible for distinct adhesive properties of carcinoma cells

1989 • 352 citations

The function of human intercellular adhesion molecule‐1 (ICAM‐1) in the generation of an immune response

1988 • 351 citations

Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesion.

1987 • 350 citations

The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain.

1989 • 343 citations

Tumor necrosis factor and interferon-gamma induce distinct patterns of endothelial activation and associated leukocyte accumulation in skin of Papio anubis.

1989 • 334 citations

Functional evidence that intercellular adhesion molecule‐1 (icam‐1) is a ligand for lfa‐1d‐ependent adhesion in t cell‐mediated cytotoxicity

1988 • 322 citations

Human lymphocyte-sheep erythrocyte rosette formation: Some characteristics of the interation

1973 • 321 citations

Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation.

1982 • 320 citations

Cells into Organs: The Forces That Shape the Embryo

1970 • 318 citations

The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit.

1990 • 316 citations

A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.

1989 • 314 citations

Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins.

1989 • 308 citations

The Biologic Roles of CD2, CD4, and CD8 in T-Cell Activation

1989 • 301 citations

A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).

1990 • 300 citations

The Developmental Biology of T Lymphocytes

1988 • 300 citations

Cell Biology of Cytotoxic and Helper T Cell Functions: Immunofluorescence Microscopic Studies of Single Cells and Cell Couples

1989 • 296 citations

Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4

1988 • 294 citations

Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.

1989 • 291 citations

Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium.

1989 • 288 citations

Association of the VLA a Subunit with a Novel Protein

1989 • 285 citations

The Regulation of Lymphocyte Traffic

1986 • 285 citations

Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.

1989 • 285 citations

Nanometre-level analysis demonstrates that lipid flow does not drive membrane glycoprotein movements

1989 • 281 citations

Transient adhesion of neutrophils to endothelium.

1989 • 279 citations

The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4

1988 • 277 citations

cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.

1987 • 277 citations

Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel.

1989 • 270 citations

The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T-cell recognition

1989 • 269 citations

Electron microscopy and structural model of human fibronectin receptor.

1988 • 265 citations

Involvement of a Leukocyte Adhesion Receptor (LFA-1) in HIV-Induced Syncytium Formation

1989 • 264 citations

The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.

1989 • 264 citations

The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex.

1988 • 258 citations

Mechanism of Specific Tumor-Cell Lysis by Alloimmune T Lymphocytes: Resolution and Characterization of Discrete Steps in the Cellular Interaction

1977 • 258 citations

Three-Dimensional Structure of Antibodies

1988 • 256 citations

A monoclonal antibody (NKI-L16) directed against a unique epitope on the alpha-chain of human leukocyte function-associated antigen 1 induces homotypic cell-cell interactions.

1988 • 248 citations

Polymorphism in the α3 domain of HLA-A molecules affects binding to CD8

1989 • 247 citations

T lymphocyte adhesion to endothelial cells: mechanisms demonstrated by anti-LFA-1 monoclonal antibodies.

1986 • 246 citations

Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells.

1990 • 238 citations

Interference reflection microscopy in cell biology: methodology and applications

1985 • 232 citations

Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets.

1987 • 231 citations

Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding

1989 • 227 citations

The Antigen-Specific, Major Histocompatibility Complex-Restricted Receptor on T Cells

1986 • 225 citations

LFA-1 and other accessory molecules functioning in adhesions of T and B lymphocytes

1987 • 223 citations

Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b.

1983 • 221 citations

Anchoring mechanisms for LFA-3 cell adhesion glycoprotein at membrane surface

1987 • 220 citations

Supergene families meet in the immune system

1988 • 213 citations

CD2-mediated adhesion facilitates T lymphocyte antigen recognition function

1989 • 209 citations

Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes.

1986 • 206 citations

Kinetics and characterization of intercellular adhesion molecule-1 (ICAM-1) expression on keratinocytes in various inflammatory skin lesions and malignant cutaneous lymphomas

1989 • 197 citations

Structure of human platelet membrane glycoproteins IIb and IIIa as determined by electron microscopy.

1985 • 194 citations

Cellular adhesion: GPIIb-IIIa as a prototypic adhesion receptor.

1989 • 187 citations

Expression of normal and mutant avian integrin subunits in rodent cells [published erratum appears in J Cell Biol 1989 Oct;109(4 Pt 1):1187]

1989 • 181 citations

An alternative leukocyte homotypic adhesion mechanism, LFA-1/ICAM-1-independent, triggered through the human VLA-4 integrin.

1990 • 180 citations

Viral receptors of the immunoglobulin superfamily

1989 • 178 citations

Synergistic T cell activation via the physiological ligands for CD2 and the T cell receptor.

1988 • 173 citations

Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system

1985 • 172 citations

A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C.

1989 • 167 citations

The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose.

1989 • 166 citations

Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations.

1985 • 145 citations

Alloantigen Recognition Is Preceded by Nonspecific Adhesion of Cytotoxic T Cells and Target Cells

1986 • 145 citations

Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2)

1987 • 143 citations

A monoclonal antibody to VLA-4 alpha-chain (CDw49d) induces homotypic lymphocyte aggregation.

1990 • 142 citations

Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome.

1989 • 135 citations

Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein.

1987 • 135 citations

The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.

1988 • 131 citations

Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor.

1987 • 128 citations

Rosetting of activated human T lymphocytes with autologous erythrocytes. Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3).

1987 • 124 citations

Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor‐mediated activation

1989 • 124 citations

Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen.

1986 • 121 citations

Lymphocyte Locomotion and Migration

2015 • 118 citations

HIV-1-Infected T Cells Show a Selective Signaling Defect After Perturbation of CD3/Antigen Receptor

1988 • 116 citations

Subpopulations of T-lymphocytes. Physical separation, functional specialisation and differentiation pathways of sub-sets of thymocytes and thymus-dependent peripheral lymphocytes.

1975 • 116 citations

The Direction of Membrane Lipid Flow in Locomoting Polymorphonuclear Leukocytes

1990 • 113 citations

Unusual expression of CD2 in sheep: implications for T cell interactions

1988 • 113 citations

Accessories or coreceptors?

1988 • 111 citations

Topology of cell adhesion molecules.

1989 • 109 citations

Distinct mutations in two patients with leukocyte adhesion deficiency and their functional correlates.

1990 • 105 citations

Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits.

1990 • 95 citations

Sialic acids and sialyltransferases in murine lymphoid cells: Indicators of T cell maturation

1975 • 94 citations

A role in transmembrane signaling for the cytoplasmic domain of the CD2 T lymphocyte surface antigen

1988 • 93 citations

Identification and characterization of a novel antigen complex on mouse mammary tumor cells using a monoclonal antibody against platelet glycoprotein Ic.

1988 • 88 citations

T‐Lymphocyte Activation: The Biology and Function of CD2 and CD4

1989 • 87 citations

Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation.

1987 • 84 citations

The sequence of rat leukosialin (W3/13 antigen) reveals a molecule with O-linked glycosylation of one third of its extracellular amino acids.

1987 • 83 citations

Biosynthesis and function of LFA-3 in human mutant cells deficient in phosphatidylinositol-anchored proteins.

1988 • 78 citations

The role of monocyte lymphocyte function‐associated antigen 1 (LFA‐1) in accessory cell function

1987 • 77 citations

Chapter 11 Univalent Antibody Fragments as Tools for the Analysis of Cell Interactions in Dictyostelium

1980 • 76 citations

Biochemical and structural studies of tenascin/hexabrachion proteins

1989 • 74 citations

Studies on cellular adhesion in tissue culture

1964 • 66 citations

Intracellular trafficking of cell surface sialoglycoconjugates.

1988 • 65 citations

The leukocyte integrin LFA-1 reconstituted by cDNA transfection in a nonhematopoietic cell line is functionally active and not transiently regulated.

1990 • 64 citations

Structural and binding analysis of a two domain extracellular CD2 molecule.

1989 • 61 citations

Purified lymphocyte function‐associated antigen‐3 and T11 target structure are active in CD2‐mediated T cell stimulation

1987 • 60 citations

A monoclonal antibody against altered LFA‐1 induces proliferation and lymphokine release of cloned T cells

1986 • 57 citations

Visualisation by low-angle shadowing of the leucocyte-common antigen. A major cell surface glycoprotein of lymphocytes.

1985 • 45 citations

Contact areas of cytotoxic lymphocytes and target cells

1975 • 44 citations

Rosetting of human T lymphocytes with sheep and human erythrocytes. Comparison of human and sheep ligand binding using purified E receptor.

1987 • 41 citations

The human LFA-3 gene is located at the same chromosome band as the gene for its receptor CD2

1988 • 40 citations

Adhesion domain of human T11 (CD2) is encoded by a single exon.

1988 • 19 citations

Platelet membrane glycoprotein I: structure and function. The domain of glycoprotein I involved in the von Willebrand receptor.

1983 • 17 citations

T cell antigen receptor: structure, assembly and function.

1989 • 13 citations

A biophysical model for interaction of cells with a surface coat (Glycocalyx). I. Electrostatic interaction profile

1983 • 12 citations