The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain

Quantitative assessment of tactile allodynia in the rat paw

1994 • 6,953 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel

1996 • 1,164 citations

Anticonvulsant drugs for management of pain: a systematic review

1995 • 711 citations

Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input

1987 • 667 citations

Myelinated afferents signal the hyperalgesia associated with nerve injury

1988 • 565 citations

Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat

1986 • 561 citations

Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug

1986 • 558 citations

The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord

1994 • 457 citations

The pathophysiology of chronic pain — increased sensitivity to low threshold Aβ-fibre inputs

1994 • 396 citations

Central post-stroke pain — a controlled trial of amitriptyline and carbamazepine

1989 • 391 citations

Carbamazepine in the Treatment of Neuralgia

1968 • 328 citations

Clinical trial of carbazepine (tegretol) in trigeminal neuralgia.

1966 • 322 citations

An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

1992 • 281 citations

Symptomatic treatment of peripheral diabetic neuropathy with carbamazepine (Tegretol�): Double blind crossover trial

1969 • 277 citations

Association of pain relief with drug side effects in postherpetic neuralgia: A single-dose study of clonidine, codeine, ibuprofen, and placebo

1988 • 251 citations

The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed byd-serine

1996 • 234 citations

Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies

1993 • 227 citations

Mechanism of action of the anticonvulsant felbamate: Opposing effects on N‐methyl‐<scp>D</scp>‐aspartate and γ‐aminobutyric acid_<scp>A</scp> receptors

1994 • 200 citations

Comparative Anticonvulsant Activity and Neurotoxicity of Felbamate and Four Prototype Antiepileptic Drugs in Mice and Rats

1986 • 196 citations

Anticonvulsant Drugs and Chronic Pain

1984 • 195 citations

Mechanism of action of the anticonvulsant felbamate: Opposing effects on N‐methyl‐<scp>D</scp>‐aspartate and γ‐aminobutyric acid_A receptors

1994 • 175 citations

Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons

1993 • 174 citations

Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors.

1993 • 156 citations

A Neuropharmacological Evaluation of Felbamate as a Novel Anticonvulsant

1992 • 145 citations

Mechanisms of Action of Currently Prescribed and Newly Developed Antiepileptic Drugs

1994 • 141 citations

Phenytoin in the treatment of diabetic symmetrical polyneuropathy

1977 • 141 citations

The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization

1997 • 123 citations

Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings

1994 • 105 citations

Effect of lamotrigine in the acute and chronic hyperalgesia induced by PGE2 and in the chronic hyperalgesia in rats with streptozotocin-induced diabetes

1995 • 95 citations

Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve

1994 • 81 citations

Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice

1994 • 71 citations

Thermal and mechanical hyperalgesia

1994 • 40 citations

Systemic Mexiletine Relieves Chronic Allodynialike Symptoms in Rats With Ischemic Spinal Cord Injury

1992 • 38 citations

Felbamate relieves several abnormal pain sensations in rats with an experimental peripheral neuropathy.

1995 • 22 citations

A comparison of the action of mexiletine and morphine in rodent models of acute and chronic pain.

1995 • 13 citations