Effects of spinally delivered N- and P-type voltage-dependent calcium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

1993 • 2,006 citations

Gabapentin for the Symptomatic Treatment of Painful Neuropathy in Patients With Diabetes Mellitus<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

1998 • 1,544 citations

Gabapentin for the Treatment of Postherpetic Neuralgia<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

1998 • 1,461 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

P-type calcium channels in rat central and peripheral neurons

1992 • 788 citations

A summary of mechanistic hypotheses of gabapentin pharmacology

1998 • 778 citations

Painful neuropathy: altered central processing maintained dynamically by peripheral input

1992 • 770 citations

Different types of calcium channels mediate central synaptic transmission

1993 • 743 citations

CALCIUM CHANNEL DIVERSITY AND NEUROTRANSMITTER RELEASE: The ω-Conotoxins and ω-Agatoxins

1994 • 734 citations

Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats

1983 • 658 citations

Calcium ions, active zones and synaptic transmitter release

1988 • 609 citations

Spinal and Trigeminal Mechanisms of Nociception

1983 • 593 citations

Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

2016 • 516 citations

Relief of post-herpetic neuralgia with the Symbol receptor antagonist ketamine: A double-blind, cross-over comparison with morphine and placebo

1994 • 483 citations

Evidence for spinalN-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

1990 • 458 citations

Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat

1992 • 419 citations

Multiple calcium channel types control glutamatergic synaptic transmission in the hippocampus

1993 • 380 citations

Localization of Ca²⁺Channel Subtypes on Rat Spinal Motor Neurons, Interneurons, and Nerve Terminals

1998 • 377 citations

The Symbol receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man

1994 • 368 citations

Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.

1997 • 362 citations

Calcium current variation between acutely isolated adult rat dorsal root ganglion neurons of different size.

1992 • 346 citations

Voltage-dependent calcium channels: From structure to function

2005 • 341 citations

Antagonists of Neuronal Calcium Channels: Structure, Function, and Therapeutic Implications

1995 • 321 citations

The role of Ca2+ channels in hippocampal mossy fiber synaptic transmission and long-term potentiation

1994 • 297 citations

Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N- and P-type channels inhibits formalin-induced nociception

1994 • 297 citations

Calcium Channels Coupled to Glutamate Release Identified by ω-Aga-IVA

1992 • 292 citations

Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia.

1994 • 289 citations

Multiple Ca2+ channel types coexist to regulate synaptosomal neurotransmitter release.

1993 • 277 citations

Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn

1986 • 273 citations

Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain.

1996 • 264 citations

Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model

1993 • 250 citations

Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord

1983 • 243 citations

Contributions of injured and intact afferents to neuropathic pain in an experimental rat model

1996 • 235 citations

Effect of continuous intrathecal infusion of ω-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats

1995 • 225 citations

Characterization of the electrically evoked release of substance P from dorsal root ganglion neurons: methods and dihydropyridine sensitivity

1988 • 190 citations

Adverse effects associated with the intrathecal administration of ziconotide

2000 • 183 citations

Electrophysiological characterization of spinal neuronal response properties in anaesthetized rats after ligation of spinal nerves L5‐L6

1998 • 170 citations

Blockade of spinal N- and P-type, but not L-type, calcium channels inhibits the excitability of rat dorsal horn neurones produced by subcutaneous formalin inflammation

1997 • 157 citations

Multiple Ca2+ currents elicited by action potential waveforms in acutely isolated adult rat dorsal root ganglion neurons

1992 • 137 citations

Use of Intrathecal SNX-111, a Novel, N-Type, Voltage-Sensitive, Calcium Channel Blocker, in the Management of Intractable Brachial Plexus Avulsion Pain

1997 • 136 citations

Synthetic omega-conopeptides applied to the site of nerve injury suppress neuropathic pains in rats.

1995 • 133 citations

Autoradiographic localization of calcium channels with [125I]ω-conotoxin in rat brain

1988 • 124 citations

Neuronal distribution and functional characterization of the calcium channel α₂δ‐2 subunit

2000 • 120 citations

Neuroanatomical distribution of receptors for a novel voltage-sensitive calcium-channel antagonist, SNX-230 (ω-conopeptide MVIIC)

1994 • 120 citations

Neurochemical evidence for the involvement of N-type calcium channels in transmitter secretion from peripheral endings of sensory nerves in guinea pigs

1990 • 111 citations

Blockade of calcium channels can prevent the onset of secondary hyperalgesia and allodynia induced by intradermal injection of capsaicin in rats

1997 • 108 citations

Human neuronal voltage-dependent calcium channels: Studies on subunit structure and role in channel assembly

1993 • 99 citations

Blockade of N- and P/Q-type calcium channels reduces the secondary heat hyperalgesia induced by acute inflammation.

1998 • 97 citations

Omega-conotoxin sensitivity and presynaptic inhibition of glutamatergic sensory neurotransmission in vitro

1994 • 85 citations

Release of calcitonin gene-related peptide like-immunoreactivity induced by electrical field stimulation from rat spinal afferents is mediated by conotoxin-sensitive calcium channels

1992 • 84 citations

Properties of structure and interaction of the receptor for ω-conotoxin, a polypeptide active on Ca 2+ channels

1988 • 83 citations

Enlargement of the Receptive Field Size to Low Intensity Mechanical Stimulation in the Rat Spinal Nerve Ligation Model of Neuropathy

2000 • 83 citations

Effects of N- and L-type calcium channel antagonists on the responses of nociceptive spinal cord neurons to mechanical stimulation of the normal and the inflamed knee joint

1996 • 78 citations

Effect of subcutaneous administration of calcium channel blockers on nerve injury-induced hyperalgesia

1998 • 77 citations

ω‐Agatoxin IVA, a P‐Type Calcium Channel Antagonist, Reduces Nociceptive Processing in Spinal Cord Neurons with Input From the Inflamed But Not From the Normal Knee Joint — An Electrophysiological Study in the Rat In Vivo

1997 • 59 citations

Involvement of P-type calcium channels in high potassium-elicited release of neurotransmitters from rat brain slices

1995 • 57 citations

A toxin (Aga-GI) from the venom of the spider Agelenopsis aperta inhibits the mammalian presynaptic Ca2+ channel coupled to glutamate exocytosis

1992 • 44 citations

Spinal application of ω-conotoxin GVIA, an N-type calcium channel antagonist, attenuates enhancement of dorsal spinal neuronal responses caused by intra-articular injection of mustard oil in the rat

1998 • 25 citations

Calcium channel blocking agents and potassium-stimulated release of glutamate from cerebellar slices

1992 • 25 citations

Suppression of hippocampal synaptic transmission by the spider toxin ω-agatoxin-IV-A

1994 • 21 citations

Rat dorsal root ganglia express distinctive forms of the α2 calcium channel subunit

2000 • 20 citations

Characterization of the presynaptic calcium channels involved in glutamate exocytosis from rat hippocampal mossy fiber synaptosomes

1990 • 20 citations

Altered effects of an A1 adenosine receptor agonist on the evoked responses of spinal dorsal horn neurones in a rat model of mononeuropathy

2000 • 13 citations