What should we be measuring in behavioral studies of chronic pain in animals?

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

1977 • 2,494 citations

Advances in Pain Research and Therapy

1980 • 2,255 citations

Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain

1994 • 803 citations

Autotomy following peripheral nerve lesions: experimental anesthesia dolorosa

1979 • 651 citations

Further evidence for ‘pain-related’ behaviours in a model of unilateral peripheral mononeuropathy

1990 • 504 citations

Translation of symptoms and signs into mechanisms in neuropathic pain

2003 • 464 citations

The relationship of pain, allodynia and thermal sensation in post-herpetic neuralgia

1996 • 258 citations

Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones?

1999 • 200 citations

Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity

2002 • 193 citations

Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.

1996 • 154 citations

Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests

1998 • 149 citations

Paclitaxel-induced neuropathic hypersensitivity in mice: Responses in 10 inbred mouse strains

2004 • 136 citations

Difficulties in stratifying neuropathic pain by mechanisms

2003 • 126 citations

The relationship between sensory thresholds and mechanical hyperalgesia in nerve injury

1998 • 96 citations

A time course analysis of the changes in spontaneous and evoked behaviour in a rat model of neuropathic pain

1992 • 84 citations

Is mechanism-based pain treatment attainable? Clinical trial issues

2000 • 62 citations

Thermal and mechanical hyperalgesia

1994 • 40 citations