Comparison of the structures of three carboxypeptidase A-phosphonate complexes determined by x-ray crystallography

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

Aromatic-Aromatic Interaction: A Mechanism of Protein Structure Stabilization

1985 • 2,441 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Weakly Polar Interactions In Proteins

1988 • 724 citations

Structural basis of the action of thermolysin and related zinc peptidases

1988 • 675 citations

Nature of Forces between Large Molecules of Biological Interest*

1948 • 514 citations

Enzymatic Catalysis and Transition-State Theory

1973 • 501 citations

AVIDIN. 1. THE USE OF [14C]BIOTIN FOR KINETIC STUDIES AND FOR ASSAY

1963 • 476 citations

TRANSITION STATE ANALOG INHIBITORS AND ENZYME CATALYSIS

1976 • 415 citations

Refined crystal structure of carboxypeptidase a at 1·54 Å resolution

1983 • 391 citations

Intermolecular potentials for the water-benzene and the benzene-benzene systems calculated in an ab initio SCFCI approximation

1983 • 299 citations

Phosphonamidates as transition-state analog inhibitors of thermolysin

1983 • 265 citations

Dimerization energetics of benzene and aromatic amino acid side chains

1986 • 262 citations

Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 Å resolution

1982 • 260 citations

A phosphonamidate dipeptide analog as an inhibitor of carboxypeptidase A

1981 • 208 citations

Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogs

1987 • 200 citations

Influence of Optically Active Acyl Groups on the Enzymatic Hydrolysis of N-Acylated-L-amino Acids

1954 • 157 citations

On the size of the active site in proteases II. Carboxypeptidase-A

1967 • 152 citations

Carboxypeptidase A. Differences in the mechanisms of ester and peptide hydrolysis

1974 • 148 citations

Phosphonate analogs of carboxypeptidase A substrates are potent transition-state analog inhibitors

1989 • 121 citations

Arginine 127 stabilizes the transition state in carboxypeptidase

1990 • 118 citations

Possible role for water dissociation in the slow binding of phosphorus-containing transition-state-analog inhibitors of thermolysin

1987 • 114 citations

Kinetics of carboxypeptidase A. I. Hydrolysis of carbobenzoxyglycyl-L-phenylalanine, benzoylglycyl-L-phenylalanine, and hippuryl-DL-.beta.-phenyllactic acid by metal-substituted and acetylated carboxypeptidases

1968 • 113 citations

Crystal structure of the complex of carboxypeptidase A with a strongly bound phosphonate in a new crystalline form: comparison with structures of other complexes

1990 • 113 citations

Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin

1986 • 110 citations

X-ray crystallographic investigation of substrate binding to carboxypeptidase A at subzero temperature.

1986 • 104 citations

Catalytic role of the metal ion of carboxypeptidase A in ester hydrolysis.

1979 • 104 citations

Kinetics of carboxypeptidase A. II. Inhibitors of the hydrolysis of oligopeptides

1970 • 103 citations

Zinc environment and cis peptide bonds in carboxypeptidase A at 1.75-A resolution.

1981 • 78 citations

Comparison of carboxypeptidase A and thermolysin: inhibition by phosphonamidates

1988 • 78 citations

STRUCTURAL REQUIREMENTS OF SPECIFIC SUBSTRATES FOR CARBOXYPEPTIDASE

1949 • 73 citations

Mechanism of carboxypeptidase A: hydration of a ketonic substrate analogue.

1987 • 68 citations

Stereochemistry of phosphate-Lewis acid interactions: implications for nucleic acid structure and recognition

1990 • 63 citations

Binding of a possible transition state analogue to the active site of carboxypeptidase A.

1985 • 57 citations

Binding of D-Phenylalanine and D-Tyrosine to Carboxypeptidase A

1989 • 56 citations

Cryospectrokinetic characterization of intermediates in biochemical reactions: carboxypeptidase A.

1984 • 47 citations

Cryospectroscopy of intermediates in the mechanism of carboxypeptidase A

1983 • 46 citations

Cryokinetic studies of the intermediates in the mechanism of carboxypeptidase A

1983 • 43 citations

Carboxypeptidase A: novel enzyme-substrate-product complex

1987 • 40 citations

Elucidation of the chemical nature of the steady-state intermediates in the mechanism of carboxypeptidase A

1986 • 38 citations

Crystallographic studies on apocarboxypeptidase A and the complex with glycyl-L-tyrosine.

1983 • 33 citations

Complex between carboxypeptidase A and a hydrated ketomethylene substrate analogue.

1988 • 31 citations

Action of Carboxypeptidase on Synthetic Substrates

1959 • 23 citations

Inhibition of thermolysin by phosphonamidate transition-state analogs: measurement of phosphorus-31-nitrogen-15 bond lengths and chemical shifts in two enzyme-inhibitor complexes by solid-state nuclear magnetic resonance

1990 • 20 citations

Hydrolysis of peptides by carboxypeptidase A: equilibrium trapping of the ES2 intermediate

1986 • 17 citations

The Mode of Action of Pancreatic Carboxypeptidase. I. Optical and Structural Specificity¹

1957 • 14 citations