Complex between carboxypeptidase A and a hydrated ketomethylene substrate analogue.

Aromatic-Aromatic Interaction: A Mechanism of Protein Structure Stabilization

1985 • 2,441 citations

Computational crystallography

2012 • 705 citations

Carboxypeptidase A: A Protein and an Enzyme

1971 • 396 citations

Refined crystal structure of carboxypeptidase a at 1·54 Å resolution

1983 • 391 citations

Functional arginyl residues in carboxypeptidase A. Modification with butanedione

1973 • 360 citations

Determining the Chemical Mechanisms of Enzyme‐Catalyzed Reactions by Kinetic Studies

1977 • 340 citations

Fluoro ketone inhibitors of hydrolytic enzymes

1985 • 336 citations

Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 Å resolution

1982 • 260 citations

On the size of the active site in proteases II. Carboxypeptidase-A

1967 • 152 citations

Carboxypeptidase A. Differences in the mechanisms of ester and peptide hydrolysis

1974 • 148 citations

Carbonic Anhydrase: Structure, Catalytic Versatility, and Inhibition

1979 • 142 citations

THE AMINO ACID SEQUENCE OF BOVINE CARBOXYPEPTIDASE A

1969 • 140 citations

Efficient structure-factor calculation for large molecules by the fast Fourier transform

1977 • 108 citations

Catalytic role of the metal ion of carboxypeptidase A in ester hydrolysis.

1979 • 104 citations

X-ray crystallographic investigation of substrate binding to carboxypeptidase A at subzero temperature.

1986 • 104 citations

Unified picture of mechanisms of catalysis by carboxypeptidase A.

1977 • 83 citations

Antiproteolytic aldehydes and ketones: substituent and secondary deuterium isotope effects on equilibrium addition of water and other nucleophiles

1977 • 68 citations

Mechanism of carboxypeptidase A: hydration of a ketonic substrate analogue.

1987 • 68 citations

Binding of a possible transition state analogue to the active site of carboxypeptidase A.

1985 • 57 citations

Crystallographic and kinetic investigations of the covalent complex formed by a specific tetrapeptide aldehyde and the serine protease from Streptomyces griseus.

1979 • 44 citations

Inhibition of carboxypeptidase A by aldehyde and ketone substrate analogs

1984 • 42 citations

Effects of pH on the structure and function of carboxypeptidase A: crystallographic studies.

1984 • 13 citations

Inhibition of carboxypeptidase A by ketones and alcohols that are isosteric with peptide substrates

1985 • 9 citations