Binding of D-Phenylalanine and D-Tyrosine to Carboxypeptidase A

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Computational crystallography

2012 • 705 citations

Carboxypeptidase A

1989 • 589 citations

Refined crystal structure of carboxypeptidase a at 1·54 Å resolution

1983 • 391 citations

Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 Å resolution

1982 • 260 citations

Models for metal ion function in carbonic anhydrase

1975 • 212 citations

Design of a diffractometer and flow cell system for X-ray analysis of crystalline proteins with applications to the crystal chemistry of ribonuclease-S

1967 • 170 citations

Binding of N-carboxymethyl dipeptide inhibitors to thermolysin determined by x-ray crystallography: a novel class of transition-state analogs for zinc peptidases

1984 • 153 citations

A survey of hydrogen bond geometries in the crystal structures of amino acids

1982 • 125 citations

STRUCTURE AND CATALYSIS OF ENZYMES

1983 • 117 citations

Carboxyl–carboxylate interactions in proteins

1982 • 109 citations

X-ray crystallographic investigation of substrate binding to carboxypeptidase A at subzero temperature.

1986 • 104 citations

Catalytic role of the metal ion of carboxypeptidase A in ester hydrolysis.

1979 • 104 citations

Comparison of carboxypeptidase A and thermolysin: inhibition by phosphonamidates

1988 • 78 citations

Carboxypeptidase A. Mechanistic analysis

1972 • 71 citations

Complex between carboxypeptidase A and a possible transition-state analog: mechanistic inferences from high-resolution x-ray structures of enzyme-inhibitor complexes

1986 • 70 citations

Acceleration of reactions by enzymes

1982 • 69 citations

Mechanism of carboxypeptidase A: hydration of a ketonic substrate analogue.

1987 • 68 citations

KINETICS AND INHIBITION OF CARBOXYPEPTIDASE ACTIVITY

1948 • 61 citations

STRUCTURAL REQUIREMENTS FOR SPECIFIC INHIBITORS OF CARBOXYPEPTIDASE

1949 • 61 citations

Models of zinc-containing proteases. Rapid amide hydrolysis by an unusually acidic Zn2+-OH2 complex

1985 • 61 citations

Binding of a possible transition state analogue to the active site of carboxypeptidase A.

1985 • 57 citations

Evidence against a crucial role for the phenolic hydroxyl of Tyr-248 in peptide and ester hydrolyses catalyzed by carboxypeptidase A: comparative studies of the pH dependencies of the native and Phe-248-mutant forms

1986 • 51 citations

The pH dependence of the nitrotyrosine-248 and arsanilazotyrosine-248 carboxypeptidase A catalyzed hydrolysis of O-(trans-p-chlorocinnamoyl)-L-.beta.-phenyllactate

1976 • 50 citations

The Hydrolysis of Diastereoisomers of Alanine Peptides by Carboxypeptidase A and Leucine Aminopeptidase^*

1966 • 49 citations

Structures of nickel(II) and cobalt(II) carboxypeptidase A

1984 • 47 citations

Kinetics of carboxypeptidase A. pH and temperature dependence of tripeptide hydrolysis

1971 • 46 citations

Carboxypeptidase A: novel enzyme-substrate-product complex

1987 • 40 citations

Structure of the complex between an unexpectedly hydrolyzed phosphonamidate inhibitor and carboxypeptidase A

1986 • 39 citations

Use of directed mutagenesis to probe the role of tyrosine 198 in the catalytic mechanism of carboxypeptidase A.

1987 • 35 citations

Interaction of anions with the active site of carboxypeptidase A

1988 • 33 citations

Complex between carboxypeptidase A and a hydrated ketomethylene substrate analogue.

1988 • 31 citations

THE EFFECT OF ANIONS ON THE ACTIVITY OF CARBOXYPEPTIDASE

1950 • 29 citations

Spectral properties of cobalt carboxypeptidase A. Interaction of the metal atom with anions

1983 • 29 citations

pH Dependence and competitive product inhibition of the carboxypeptidase A catalyzed hydrolysis of O-(trans-cinnamoyl) L-.beta.-phenyllactate

1969 • 26 citations

Chlorine-35 nuclear magnetic resonance investigation of carboxypeptidase A

1974 • 25 citations

Novel structure of the complex between carboxypeptidase A and a ketonic substrate analog

1985 • 24 citations

13C NMR studies of d- and l-phenylalanine binding to cobalt(II) carboxypeptidase A

1988 • 22 citations

13 C NMR studies of carboxylate inhibitor binding to cobalt(II) carboxypeptidase A

1988 • 20 citations

The pH dependency of the zinc and cobalt carboxypeptidase catalyzed enolization of (R)-2-benzyl-3-(p-methoxybenzoyl)propionic acid

1983 • 17 citations

Effects of pH on the structure and function of carboxypeptidase A: crystallographic studies.

1984 • 13 citations