The Pathophysiology of Fatal Familial Insomnia

Thalamocortical Oscillations in the Sleeping and Aroused Brain

1993 • 3,483 citations

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1992 • 1,632 citations

The Central Autonomic Network: Functional Organization, Dysfunction, and Perspective

1993 • 1,301 citations

The cellular prion protein binds copper in vivo

1997 • 1,263 citations

The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle

1972 • 1,091 citations

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

1996 • 872 citations

Prion protein is necessary for normal synaptic function

1994 • 802 citations

Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy

1994 • 663 citations

HYPOTHALAMIC REGULATION OF SLEEP IN RATS. AN EXPERIMENTAL STUDY

1946 • 655 citations

Altered circadian activity rhythms and sleep in mice devoid of prion protein

1996 • 655 citations

Brain Mechanisms and Consciousness

1955 • 631 citations

129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal

1994 • 563 citations

Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene

1996 • 483 citations

The sleep-waking cycle

1972 • 476 citations

The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells

1997 • 435 citations

Sleep and Sleep Regulation in Normal and Prion Protein-Deficient Mice

1997 • 296 citations

Identification of two biologically distinct strains of transmissible mink encephalopathy in hamsters

1992 • 276 citations

Forebrain inhibitory mechanisms: Cortical synchronization induced by basal forebrain stimulation

1962 • 244 citations

Hypersomnia following paramedian thalamic stroke: A report of 12 patients

1996 • 218 citations

Complementary hydropathy identifies a cellular prion protein receptor

1997 • 184 citations

Hippocampal slices from prion protein null mice: disrupted Ca2+-activated K+ currents

1996 • 184 citations

Regional distribution of protease‐resistant prion protein in fatal familial insomnia

1995 • 164 citations

Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein

1995 • 146 citations

Sleep-wakefulness, EEG and behavioral studies of chronic cats without the thalamus: the 'athalamic' cat.

1972 • 132 citations

A unique membrane protein is expressed on early developing limbic system axons and cortical targets

1988 • 132 citations

Isolation, biochemical characterization and ultrastructural analysis of the limbic system-associated membrane protein (LAMP), a protein expressed by neurons comprising functional neural circuits.

1990 • 114 citations

Isolation, biochemical characterization and ultrastructural analysis of the limbic system-associated membrane protein (LAMP), a protein expressed by neurons comprising functional neural circuits

1990 • 107 citations

Pseudo-hypersomnia and pre-sleep behaviour with bilateral paramedian thalamic lesions

1993 • 101 citations

Sleep-wakefulness, EEG and behavioral studies of chronic cats without neocortex and striatum: the 'diencephalic' cat.

1972 • 96 citations

Cerebral metabolism in fatal familial insomnia: Relation to duration, neuropathology, and distribution of protease-resistent prion protein

1997 • 94 citations

Thalamic haemorrhage

1996 • 93 citations

Sleep-wake cycle abnormalities in fatal familial insomnia. Evidence of the role of the thalamus in sleep regulation

1995 • 91 citations

Conservation of the cellular gene encoding the scrapie prion protein

1986 • 85 citations

Fatal familial insomnia

1996 • 73 citations

Prion protein is necessary for latent learning and long-term memory retention.

1997 • 58 citations

Sleep and sleep disorders : from molecule to behavior

1997 • 50 citations

The thalamus and insomnia.

1992 • 50 citations

Fatal familial insomnia: Sleep, neuroendocrine and vegetative alterations

1995 • 38 citations

Changes in sleep-waking cycle induced by lesions of medialis dorsalis thalamic nuclei in the cat

1988 • 31 citations

Multiple roles for PrP in the prion diseases

1996 • 22 citations

A Study on the Central Representation of Sleep Behaviour

1964 • 15 citations

Molecular Regulation of Arousal States

1997 • 4 citations