Proteolytic Degradation of Heme-Modified Hepatic Cytochromes P450: A Role for Phosphorylation, Ubiquitination, and the 26S Proteasome?

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1995 • 1,296 citations

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1988 • 1,294 citations

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1995 • 1,285 citations

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1983 • 1,105 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

The multicatalytic and 26 S proteases.

1993 • 476 citations

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1997 • 454 citations

Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

1996 • 451 citations

Role of Cue1p in Ubiquitination and Degradation at the ER Surface

1997 • 386 citations

Degradation of a Mutant Secretory Protein, α1-Antitrypsin Z, in the Endoplasmic Reticulum Requires Proteasome Activity

1996 • 362 citations

Targeting of substrates to the 26S proteasome

1997 • 362 citations

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1984 • 324 citations

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

1993 • 323 citations

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1997 • 309 citations

Cdc53 Targets Phosphorylated G1 Cyclins for Degradation by the Ubiquitin Proteolytic Pathway

1996 • 306 citations

Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

1985 • 301 citations

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1986 • 299 citations

Induction of Rat Hepatic N-Nitrosodimethylamine Demethylase by Acetone Is Due to Protein Stabilization

1989 • 277 citations

Ethanol Induces CYP2E1 by Protein Stabilization

1995 • 264 citations

Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates

1985 • 263 citations

Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450.

1984 • 246 citations

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin in Cultured Cells

1997 • 231 citations

Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B.

1994 • 209 citations

Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity.

1993 • 208 citations

A New Inhibitor of the Chymotrypsin‐Like Activity of the Multicatalytic Proteinase Complex (20S Proteasome) Induces Accumulation of Ubiquitin‐Protein Conjugates in a Neuronal Cell

1994 • 183 citations

Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture.

1986 • 177 citations

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1986 • 168 citations

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Hemin inhibits ATP-dependent ubiquitin-dependent proteolysis: role of hemin in regulating ubiquitin conjugate degradation.

1981 • 141 citations

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Destruction of heme and hemoproteins mediated by liver microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase

1978 • 139 citations

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1997 • 138 citations

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1992 • 119 citations

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1978 • 117 citations

Substrate-, hormone-, and cAMP-regulated cytochrome P450 degradation.

1990 • 112 citations

Structure−Function Relationships of Human Liver Cytochromes P450 3A: Aflatoxin B1 Metabolism as a Probe

1998 • 112 citations

Evidence of Proteasome-mediated Cytochrome P-450 Degradation

1997 • 109 citations

Regulated intracellular degradation of apolipoprotein B in semipermeable HepG2 cells.

1994 • 108 citations

Degradation of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Endoplasmic Reticulum Membranes Is Accelerated as a Result of Increased Susceptibility to Proteolysis

1996 • 104 citations

Cytochrome P-450 and NADPH-cytochrome P-450 reductase are degraded in the autolysosomes in rat liver [published erratum appears in J Cell Biol 1987 Jul;105(1):609]

1987 • 101 citations

A Two-site Model for ApoB Degradation in HepG2 Cells

1997 • 89 citations

QSR1, an Essential Yeast Gene with a Genetic Relationship to a Subunit of the Mitochondrial Cytochromebc 1 Complex, Codes for a 60 S Ribosomal Subunit Protein

1997 • 88 citations

Interaction of Ascorbate and α-Tocopherol in Resealed Human Erythrocyte Ghosts

1996 • 83 citations

Acetone‐regulated synthesis and degradation of cytochrome P4502E2 and cytochrome P4502B1 in rat liver

1991 • 79 citations

The inactivation of ubiquitin accounts for the inability to demonstrate ATP, ubiquitin-dependent proteolysis in liver extracts.

1985 • 77 citations

Differential time course of induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by Aroclor 1254

1983 • 73 citations

Degradation of rat liver cytochromes P450 3A after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: Characterization of the proteolytic system

1992 • 63 citations

Substrate-regulated, cAMP-dependent phosphorylation, denaturation, and degradation of glucocorticoid-inducible rat liver cytochrome P450 3A1

1994 • 62 citations

Degradation of rat hepatic cytochrome P-450 heme by 3,5-dicarbethoxy-2, 6-dimethyl-4-ethyl-1,4-dihydropyridine to irreversibly bound protein adducts

1987 • 61 citations

ATP-stimulated proteolysis in soluble extracts of BHK 21C13 cells

1988 • 60 citations

Identification of the Heme-Modified Peptides from Cumene Hydroperoxide-Inactivated Cytochrome P450 3A4

1998 • 57 citations

The site of cyclic AMP‐dependent protein kinase catalyzed phosphorylation of cytochrome P‐450 LM2

1985 • 54 citations

[30] Cytochrome P450 turnover

1991 • 53 citations

Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450.

1989 • 52 citations

Hemin inhibits ubiquitin-dependent proteolysis in both a higher plant and yeast

1988 • 46 citations

Inactivation of multiple hepatic cytochrome P-450 isozymes in rats by allylisopropylacetamide: mechanistic implications.

1987 • 43 citations

Posttranslational modification of hepatic cytochrome P-450. Phosphorylation of phenobarbital-inducible P-450 forms PB-4 (IIB1) and PB-5 (IIB2) in isolated rat hepatocytes and in vivo

1989 • 40 citations

Purification and Characterization of Two Membrane-Bound Serine Proteinases from Rat Liver Microsomes Active in Degradation of Cytochrome P450

1993 • 40 citations

Cumene hydroperoxide-mediated inactivation of cytochrome P450 2B1. Identification of an active site heme-modified peptide.

1993 • 39 citations

Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: A case for distinct proteolytic mechanisms?

1992 • 38 citations

3,4-dichloroisocoumarin-induced activation of the degradation of beta-casein by the bovine pituitary multicatalytic proteinase complex.

1992 • 36 citations

Identification of the Heme Adduct and an Active Site Peptide Modified during Mechanism-Based Inactivation of Rat Liver Cytochrome P450 2B1 by Secobarbital

1996 • 33 citations

Differential Effects of Ubiquitin Aldehyde on Ubiquitin and ATP-Dependent Protein Degradation

1996 • 32 citations

Relationship between phosphorylation and cytochrome P450 destruction

1990 • 32 citations

‘ER degradation’ of a mutant yeast plasma membrane protein by the ubiquitin‐proteasome pathway

1998 • 31 citations

Phosphorylation of cytochrome P450 isoenzymes in intact hepatocytes and its importance for their function in metabolic processes

1990 • 28 citations

PHOSPHORYLATION OF CYTOCHROME P4502E1 (CYP2E1) BY CALMODULIN DEPENDENT PROTEIN KINASE PROTEIN KINASE C AND cAMP DEPENDENT PROTEIN KINASE

1993 • 28 citations

The structures of ubiquitin conjugates of yeast Iso-2-cytochrome c

1991 • 25 citations

Degradation of Rat Hepatic Cytochrome P-450p

1989 • 23 citations

Ubiquitin conjugation to cytochromes c. Structure of the yeast iso-1 conjugate and possible recognition determinants.

1992 • 22 citations

Protein Phosphorylation Changes Ligand-Binding Efficiency of Cytochrome P450c17 (CYP17) and Accelerates Its Proteolytic Degradation: Putative Relevance for Hormonal Regulation of CYP17 Activity

1997 • 17 citations

Irreversible binding of heme to microsomal protein during inactivation of cytochrome P450 by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine

1990 • 13 citations