Regulated intracellular degradation of apolipoprotein B in semipermeable HepG2 cells.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin a suggests an ER recycling pathway

1990 • 972 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

A New Method for Simultaneous Purification of Cytochrome b5 and NADPH-cytochrome c Reductase from Rat Liver Microsomes

1970 • 635 citations

Degradation from the endoplasmic reticulum: Disposing of newly synthesized proteins

1988 • 488 citations

Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B.

1991 • 421 citations

The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life.

1989 • 414 citations

Role of carbohydrates in protein secretion and turnover: Effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts

1978 • 391 citations

Intrahepatic assembly of very low density lipoproteins. Rate of transport out of the endoplasmic reticulum determines rate of secretion.

1987 • 300 citations

Insulin modulation of hepatic synthesis and secretion of apolipoprotein B by rat hepatocytes.

1990 • 251 citations

The cytoskeleton of digitonin-treated rat hepatocytes.

1980 • 238 citations

Optimum Reaction Conditions for Human Lactate Dehydrogenase Isoenzymes as They Affect Total Lactate Dehydrogenase Activity

1968 • 217 citations

Inhibitory Effect of di- and Tripeptidyl Aldehydes on Calpains and Cathepsins

1990 • 204 citations

Effect of tunicamycin on the secretion of serum proteins by primary cultures of rat and chick hepatocytes. Studies on transferrin, very low density lipoprotein, and serum albumin

1978 • 195 citations

Apolipoprotein B is both integrated into and translocated across the endoplasmic reticulum membrane. Evidence for two functionally distinct pools.

1990 • 192 citations

Degradation of newly synthesized apolipoprotein B-100 in a pre-Golgi compartment.

1990 • 182 citations

The assembly and secretion of ApoB 100-containing lipoproteins in Hep G2 cells. ApoB 100 is cotranslationally integrated into lipoproteins.

1992 • 170 citations

Effects of oleate and insulin on the production rates and cellular mRNA concentrations of apolipoproteins in HepG2 cells.

1989 • 150 citations

Genetic factors controlling structure and expression of apolipoproteins B and E in mice.

1987 • 144 citations

Oleate-mediated stimulation of apolipoprotein B secretion from rat hepatoma cells. A function of the ability of apolipoprotein B to direct lipoprotein assembly and escape presecretory degradation.

1992 • 144 citations

Studies of the sites of intracellular degradation of apolipoprotein B in Hep G2 cells.

1992 • 131 citations

The assembly and secretion of apoB 100 containing lipoproteins in Hep G2 cells. Evidence for different sites for protein synthesis and lipoprotein assembly.

1990 • 123 citations

Intracellular degradation of the transport-impaired human PiZ alpha 1-antitrypsin variant. Biochemical mapping of the degradative event among compartments of the secretory pathway.

1990 • 111 citations

Inhibition of degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo by cysteine protease inhibitors

1991 • 109 citations

Protein degradation by the phosphoinositide-specific phospholipase C-alpha family from rat liver endoplasmic reticulum.

1992 • 100 citations

Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in a nonhepatic cell line.

1992 • 97 citations

Impaired hepatic apolipoprotein B and E translation in streptozotocin diabetic rats.

1992 • 79 citations

Intrahepatic assembly of very low density lipoproteins: immunologic characterization of apolipoprotein B in lipoproteins and hepatic membrane fractions and its intracellular distribution.

1989 • 77 citations

Endoplasmic reticulum degradation of a subunit of the asialoglycoprotein receptor in vitro. Vesicular transport from endoplasmic reticulum is unnecessary.

1992 • 74 citations

Association and assembly of triglyceride and phospholipid with glycosylated and unglycosylated apoproteins of very low density lipoprotein in the intact liver cell.

1982 • 66 citations

Cell‐free systems to study vesicular transport along the secretory and endocytic pathways ¹

1989 • 60 citations

Transit and sorting of apolipoprotein B within the endoplasmic reticulum and Golgi compartments of isolated hepatocytes from normal and orotic acid-fed rats.

1993 • 55 citations

3-Hydroxy-3-methylglutaryl-coenzyme A reductase and T cell receptor alpha subunit are differentially degraded in the endoplasmic reticulum.

1992 • 52 citations

Insulin modulation of human apolipoprotein B mRNA translation: studies in an in vitro cell-free system from HepG2 cells

1992 • 52 citations

Secretion of apolipoprotein B in serum‐free cultures of human hepatoma cell line, HepG2

1990 • 46 citations

Studies with digitonin‐treated rat hepatocytes (nude cells)

1985 • 42 citations

Inhibition of apolipoprotein E degradation in a post-Golgi compartment by a cysteine protease inhibitor.

1993 • 40 citations

Butyrate stimulates the secretion of apolipoprotein (apo) A-I and apo B100 by the human hepatoma cell line Hep G2. Induction of apo A-I mRNA with no change of apo B100 mRNA

1991 • 38 citations

Thyroid hormone modulates apolipoprotein B gene expression in HepG2 cells

1992 • 38 citations

ATP-dependent degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in permeabilized cells.

1987 • 37 citations

Degradation of secretory immunoglobulin M in B lymphocytes occurs in a postendoplasmic reticulum compartment and is mediated by a cysteine protease.

1992 • 35 citations

Regulated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in permeabilized cells.

1992 • 31 citations

Role of carbohydrate in glycoprotein secretion by human hepatoma cells

1985 • 16 citations