Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

An improved algorithm for matching biological sequences

1982 • 1,728 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

Purification and Characterization of a Protein Inhibitor of Adenosine 3',5'-Monophosphate-dependent Protein Kinases

1971 • 892 citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

1989 • 609 citations

Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene.

1986 • 559 citations

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

1986 • 408 citations

Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family.

1987 • 317 citations

Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver.

1982 • 275 citations

Sex differences in the effects of abnormal physiological states on the metabolism of drugs by rat liver microsomes.

1965 • 259 citations

Activation of Protein Kinase by Physiological Concentrations of Cyclic AMP

1974 • 255 citations

Measurement of cytochrome P-450 dependent dealkylation of alkoxy-phenoxazones in hepatic S9s and hepatocyte homogenates: effects of dicumarol

1985 • 236 citations

Hepatic cytochromeP-450 monooxygenase system

1983 • 214 citations

Bovine adrenocortical cytochrome P-450(17 alpha). Regulation of gene expression by ACTH and elucidation of primary sequence.

1986 • 211 citations

Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex.

1984 • 208 citations

Primary Structure of the P450 Lanosterol Demethylase Gene fromSaccharomyces cerevisiae

1987 • 178 citations

Simultaneous purification of multiple forms of rat liver microsomal cytochrome P-450 by high-performance liquid chromatography

1985 • 156 citations

Debrisoquine 4-Hydroxylase: Characterization of a New P450 Gene Subfamily, Regulation, Chromosomal Mapping, and Molecular Analysis of the DA Rat Polymorphism

1987 • 139 citations

Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat.

1984 • 130 citations

Rat testosterone 7 alpha-hydroxylase. Isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene.

1987 • 103 citations

Protein kinase activity and substrates at the surface of intact HeLa cells.

1982 • 102 citations

Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3' untranslated region of a liver mRNA.

1986 • 92 citations

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1987 • 91 citations

Amino acid sequence of the Pseudomonas putida cytochrome P-450. II. Cyanogen bromide peptides, acid cleavage peptides, and the complete sequence.

1982 • 78 citations

The complete amino acid sequence of a constitutive form of liver microsomal cytochrome P-450.

1985 • 78 citations

A rapid method for the measurement of [γ-32P]ATP specific radioactivity in tissue extracts and its application to the study of 32Pi uptake in perfused rat heart

1976 • 75 citations

The covalent structure of rabbit phenobarbital-induced cytochrome P-450. Partial amino acid sequence and order of cyanogen bromide peptides.

1982 • 63 citations

cDNA and derived amino acid sequence of ethanol-inducible rabbit liver cytochrome P-450 isozyme 3a (P-450ALC).

1987 • 61 citations

The site of cyclic AMP‐dependent protein kinase catalyzed phosphorylation of cytochrome P‐450 LM2

1985 • 54 citations

Role of the electron transfer system in microsomal drug monooxygenase reaction catalyzed by cytochrome P-450

1984 • 53 citations

Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450.

1989 • 52 citations

Isoenzyme-specific phosphorylation of cytochromes P-450 and other drug metabolizing enzymes

1987 • 51 citations

Structural Gene Products of the Murine Ah Complex

2005 • 49 citations

Phosphorylation of cytochrome-P-450-dependent monooxygenase components

1983 • 49 citations

Sequencing of cDNA inserts encoding aromatase cytochrome P-450 (P-450AROM)

1987 • 48 citations

Conversion of hepatic microsomal cytochrome P-450 to P-420 upon phosphorylation by cyclic AMP dependent protein kinase

1985 • 47 citations

Phosphorylation of rabbit liver cytochrome P-450 LM2 and its effect on monooxygenase activity

1984 • 47 citations

Posttranslational modification of hepatic cytochrome P-450. Phosphorylation of phenobarbital-inducible P-450 forms PB-4 (IIB1) and PB-5 (IIB2) in isolated rat hepatocytes and in vivo

1989 • 40 citations

Turnover of Two Drug-Inducible Forms of Microsomal Cytochrome P-450 in Rat Liver1

1983 • 38 citations

Interaction of drugs and hepatic microsomes.

1962 • 34 citations

Isolation of the Catalytic Subunits of Cyclic AMP-dependent Protein Kinases from Different Mammalian Tissues on the Basis of Charge Differences of Their Subunits

1979 • 33 citations

Complete Sequence of Cytochrome P450 3c cDNA and Presence of Two mRNA Species with 3′ Untranslated Regions of Different Lengths

1988 • 29 citations

Metabolic activation capabilities of S9 and hepatocytes from uninduced rats to convert carcinogenic N-nitrosamines to mutagens

1984 • 28 citations

Phenobarbital-dependent proliferation of putative initiated rat hepatocytes

1988 • 28 citations

Phosphorylation of microsome-bound cytochrome P-450 LM2

1986 • 24 citations

Effect of glucose on induction of δ-aminolevulinic acid synthase, ferrochelatase and cytochrome P-450 hemoproteins in isolated rat hepatocytes by phenobarbital and lead

1985 • 22 citations

Inhibition of hepatic drug metabolism by cyclic 3',5'-adenosine monophosphate.

1972 • 16 citations

Catalytic Subunit of Adenosine Cyclic 3',5' Monophosphate- Dependent Protein Kinase from Rat Muscle: Basic Properties and Factors Influencing the Activity

1979 • 12 citations

Sex-dependent effects of cyclic AMP on the hepatic mixed function oxidase system.

1973 • 9 citations

Effect of Cyclic Amp on the Phenobarbital Induced Increase in Cytochrome P-450 and Hypertrophy of the Endoplasmic Reticulum of the Rat Liver

1975 • 7 citations

Studies on the mechanism of inhibition of drug biotransformation by cyclic adenine nucleotides.

1972 • 4 citations

Separation and purification of component proteins of the cytochrome P-450-dependent microsomal monooxygenase system by high-performance liquid chromatography

1989 • 3 citations