Cerebrovascular Disease and the Blood-Brain Barrier

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

A new model of bilateral hemispheric ischemia in the unanesthetized rat.

1979 • 1,934 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion

1981 • 1,420 citations

Cerebral ischemia. II. The no-reflow phenomenon.

1968 • 1,346 citations

The Concept of a Blood-Brain Barrier

1980 • 812 citations

Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model

1984 • 741 citations

The free radical pathology and the microcirculation in the major central nervous system disorders.

1980 • 660 citations

Anoxic-ischemic encephalopathy in rats.

1960 • 644 citations

The pathophysiology of brain ischemia

1983 • 637 citations

Cerebral circulation and metabolism

1984 • 590 citations

An approach to free radicals in medicine and biology.

1980 • 548 citations

Pathology of the cerebral blood vessels

1972 • 406 citations

The blood-brain barrier to proteins under normal and pathological conditions

1970 • 402 citations

George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury.

1985 • 393 citations

Experimental brain infarcts in cats. II. Ischemic brain edema.

1980 • 363 citations

The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion

1985 • 354 citations

Synthesis of Compounds with Properties of Leukotrienes C ₄ and D ₄ in Gerbil Brains After Ischemia and Reperfusion

1984 • 350 citations

The Concept of a Blood-Brain Barrier

1980 • 347 citations

REGIONAL CEREBRAL BLOOD FLOW DURING MIGRAINE ATTACKS BY XENON-133 INHALATION AND EMISSION TOMOGRAPHY

1984 • 328 citations

Hemodynamic aspects of cerebral arteriovenous malformations

1980 • 306 citations

Focal Cerebral Ischaemia in the Rat: 2. Regional Cerebral Blood Flow Determined by [¹⁴C]Iodoantipyrine Autoradiography following Middle Cerebral Artery Occlusion

1981 • 306 citations

Ischemic brain edema following occlusion of the middle cerebral artery in the rat. I: The time courses of the brain water, sodium and potassium contents and blood-brain barrier permeability to 125I-albumin.

1985 • 300 citations

Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex

1984 • 300 citations

PROPAGATION OF SPREADING CORTICAL DEPRESSION

1945 • 287 citations

Transient Formation of Superoxide Radicals in Polyunsaturated Fatty Acid‐Induced Brain Swelling

1980 • 267 citations

Stroke: Pathophysiology, Diagnosis, and Management

1986 • 262 citations

Subcortical Arteriosclerotic Encephalopathy (Binswanger's Disease)

1985 • 256 citations

Positron Emission Tomography in the Newborn: Extensive Impairment of Regional Cerebral Blood Flow with Intraventricular Hemorrhage and Hemorrhagic Intracerebral Involvement

1983 • 247 citations

Intracranial Arteriovenous Malformations

1985 • 228 citations

Treatment of Experimental Cerebral Ischemia

1982 • 224 citations

Brain edema during ischemia and after restoration of blood flow. Measurement of water, sodium, potassium content and plasma protein permeability.

1979 • 222 citations

Experimental brain infarcts in cats. I. Pathophysiological observations.

1980 • 222 citations

Evaluation of the dye-protein tracers in pathophysiology of the blood-brain barrier

1981 • 219 citations

Report of Joint Committee for Stroke Resources. IV. Brain edema in stroke.

1977 • 217 citations

Delayed radiation necrosis of the brain

1977 • 207 citations

CEREBRAL METABOLISM IN ISCHAEMIA: NEUROCHEMICAL BASIS FOR THERAPY

1985 • 206 citations

Prostaglandin I2 and indomethacin prevent impairment of post-ischemic brain reperfusion in the dog.

1979 • 202 citations

Permeability of blood-brain barrier to various sized molecules

1985 • 188 citations

The effect of a lipid hydroperoxide of arachidonic acid on the canine basilar artery

1981 • 175 citations

The Cerebral Collateral Circulation

1957 • 172 citations

The blood-brain barrier to protein tracers in focal cerebral ischemia and infarction caused by occlusion of the middle cerebral artery

1971 • 170 citations

Leukotriene production in gerbil brain after ischemic insult, subarachnoid hemorrhage, and concussive injury

1985 • 166 citations

Blood‐Brain Barrier in Physiology and Medicine

1977 • 166 citations

The Cerebral Venous System and its Disorders

1985 • 165 citations

Carotici Artery Disease Following ExternalCervical Irradiation

1981 • 162 citations

Leukotrienes in the rat central nervous system.

1984 • 162 citations

PRESSURE PASSIVE CEREBRAL BLOOD FLOW AND BREAKDOWN OF THE BLOOD‐BRAIN BARRIER IN EXPERIMENTAL FETAL ASPHYXIA

1979 • 158 citations

Edema and Vascular Permeability in Cerebral Ischemia

1982 • 158 citations

Leukotrienes increase blood‐brain barrier permeability following intraparenchymal injections in rats

1985 • 155 citations

Recovery of Neuronal Function after Prolonged Cerebral Ischemia

1970 • 150 citations

Hypoxic-Ischemic Encephalopathy in the Newborn

1983 • 146 citations

Prevention of chronic experimental cerebral vasospasm with ibuprofen and high-dose methylprednisolone

1983 • 146 citations

Role of veins and cerebral venous pressure in disruption of the blood-brain barrier.

1986 • 146 citations

Experimental cerebral ischemia in Mongolian gerbils

1976 • 142 citations

Radiation Damage to the Nervous System

1981 • 137 citations

Barrier disruption in the major cerebral arteries following experimental subarachnoid hemorrhage

1985 • 129 citations

Cerebral blood flow regulation during experimental brain compression

1973 • 126 citations

Pathology of the Cerebral Blood Vessels.

1973 • 125 citations

Natural history of experimental intracerebral hemorrhage: sonography, computed tomography and neuropathology.

1981 • 120 citations

Red cerebral veins and the cerebral steal syndrome

1971 • 114 citations

The role of arachidonic acid in vasogenic brain edema.

1984 • 111 citations

Edema and Necrosis in Experimental Cerebral Infarction

1963 • 110 citations

Experimental cerebral oligemia and ischemia produced by intracranial hypertension

1975 • 110 citations

Leukotrienes in inflammation

1986 • 108 citations

Ischemic Cerebral Edema and the Blood-Brain Barrier

1974 • 107 citations

Ischaemic brain damage in the gerbil in the absence of 'no-reflow'.

1975 • 106 citations

Role of extracellular proteins in the dynamics of vasogenic brain edema

1985 • 106 citations

BRAIN OEDEMA FOLLOWING BRAIN ISCHAEMIA AND THE INFLUENCE OF THERAPY

1985 • 105 citations

Eicosanoids in the central nervous system

1985 • 104 citations

Evidence that disruption of the blood-brain barrier precedes reduction in cerebral blood flow in hypertensive encephalopathy.

1984 • 103 citations

Ischemic cerebral edema. A review.

1979 • 102 citations

The influence of systemic arterial pressure and intracranial pressure on the development of cerebral vasogenic edema

1983 • 101 citations

Parasagittal cerebral injury in neonatal hypoxic-ischemic encephalopathy: Clinical and neuroradiologic features

1977 • 101 citations

Modification of acute focal ischemia by treatment with mannitol.

1978 • 100 citations

Spreading Cerebral Oligemia in Classical‐ and Normal Cerebral Blood Flow in Common Migraine

1982 • 100 citations

O2 radicals in arachidonate-induced increased blood-brain barrier permeability to proteins

1986 • 100 citations

Cerebral fat embolism: a neuropathological study of a microembolic state.

1980 • 100 citations

Early changes in blood brain barrier permeability to small molecules after transient cerebral ischemia.

1984 • 99 citations

Prostaglandin I₂, indomethacin, and heparin promote postischemic neuronal recovery in dogs

1982 • 98 citations

Cerebral metabolism in newborn dogs during reversible asphyxia

1977 • 92 citations

Hemispheric blood flow in the rat after unilateral common carotid occlusion: evolution with time.

1985 • 85 citations

Cerebral changes in chronic hypertension: Combined permeability and immunohistochemical studies

1984 • 84 citations

Cerebral infarction in rats using homologous blood emboli: development of a new experimental model.

1985 • 81 citations

Microangiography and Vascular Permeability of the Subependymal Matrix in the Premature Infant

1978 • 77 citations

Subcortical arteriosclerotic encephalopathy: CT spectrum and pathologic correlation

1986 • 76 citations

Cerebral edema following experimental subarachnoid hemorrhage.

1982 • 76 citations

Cerebrovascular lesions in stroke-prone spontaneously hypertensive rats

1985 • 75 citations

Eicosapentaenoic acid: effect on brain prostaglandins, cerebral blood flow and edema in ischemic gerbils.

1984 • 74 citations

Effect of chronic hypertension on the blood-brain barrier.

1980 • 72 citations

In vivo toxic effects of halothane on canine cerebral metabolic pathways

1975 • 71 citations

Dissecting aneurysm of the middle cerebral artery associated with migraine syndrome.

1953 • 70 citations

Neuronal alterations in developing cortical infarction

1974 • 68 citations

Serum Immunocomplexes in Patients with Subarachnoid Hemorrhage

1986 • 68 citations

Selective Extravascular Escape of Albumin into the Cerebral Cortex of the Diabetic Rat

1981 • 67 citations

Moyamoya pattern of vascular occlusion after radiotherapy for glioma of the optic chiasm

1986 • 66 citations

Neuronal control of brain microvessel function

1985 • 64 citations

Cerebral vascular bed in hypertension and consequences for the brain.

1984 • 64 citations

Brain nuclear magnetic resonance imaging enhanced by a paramagnetic nitroxide contrast agent: preliminary report

1983 • 63 citations

Cerebral infarction after middle cerebral artery occlusion in progenies of spontaneously stroke-prone and normal rats.

1984 • 62 citations

Barrier Disruption in the Major Cerebral Arteries during the Acute Stage after Experimental Subarachnoid Hemorrhage

1986 • 60 citations

Ischemic brain edema following occlusion of the middle cerebral artery in the rat. II: Alteration of the eicosanoid synthesis profile of brain microvessels.

1985 • 60 citations

High-flow angiopathy: cerebral blood vessel changes in experimental chronic arteriovenous fistula.

1986 • 60 citations

Blood-brain barrier permeability to sucrose and dextran after osmotic opening

1984 • 60 citations

The Leukotrienes in Allergy and Inflammation

1982 • 58 citations

"Low perfusion hyperemia" following middle cerebral arterial occlusion in cats of different age groups.

1980 • 58 citations

Cerebrovascular permeability following MCA occlusion in the rat

1982 • 58 citations

Effect of hypertension on blood-brain barrier. Change after restoration of blood flow in post-ischemic gerbil brains. An electronmicroscopic study.

1980 • 56 citations

Cerebral protection

1986 • 53 citations

Migrainous cerebral infarction: a tomographic study of cerebral blood flow and oxygen extraction fraction with the oxygen-15 inhalation technique.

1980 • 51 citations

Cerebral air embolism occurring at angiography and diagnosed by computerized tomography

1984 • 51 citations

Delayed high dose contrast CT: identifying patients at risk of massive hemorrhagic infarction

1981 • 51 citations

Radiation Brain Damage Induced by Interstitial 125I Sources: A Canine Model Evaluated by Quantitative Computed Tomography

1985 • 50 citations

The blood-brain barrier following experimental subarachnoid hemorrhage

1983 • 50 citations

Transient appearance of "no-reflow" phenomenon in Mongolian gerbils.

1980 • 50 citations

Periventricular, Intraventricular Hemorrhages in the Premature Newborn

1984 • 49 citations

Blood-brain barrier changes after experimental subarachnoid haemorrhage

1982 • 49 citations

Resolving intracerebral hematoma: alteration of the "ring sign" with steroids

1978 • 49 citations

Experimental cerebral oligemia and ischemia produced by intracranial hypertension

1975 • 48 citations

The blood-brain barrier following experimental subarachnoid hemorrhage

1983 • 47 citations

Early CT Findings of Global Central Nervous System Hypoperfusion

1983 • 47 citations

Cerebral Microvascular Injury in Experimental Drug Abuse

1976 • 47 citations

Serial MR imaging in neonatal cerebral injury.

1987 • 46 citations

Radionuclide Brain‐scanning in Perinatal Hypoxia/Ischemia

1979 • 46 citations

Ultrastructural studies on blood-brain barrier dysfunction after cerebral air embolism in the rat

1978 • 46 citations

The blood-brain barrier in hypoxia: Ultrastructural aspects and adenylate cyclase activity of brain capillaries

1984 • 45 citations

Significance of contrast enhancement in cranial computerized tomography after subarachnoid hemorrhage

1984 • 45 citations

Perinatal Brain Injury and Cerebral Blood Flow in Newborn Infants

1985 • 44 citations

Treatment of acute focal cerebral ischemia with prostacyclin.

1983 • 43 citations

Spontaneous germinal matrix and intraventricular hemorrhage in prematurely born rabbits

1982 • 42 citations

Computed tomographic changes of hypertensive encephalopathy.

1985 • 42 citations

Response of chronic experimental cerebral vasospasm to methylprednisolone and dexamethasone

1984 • 42 citations

The effect of hyperglycemia on brain capillary permeability in the lizard, Anolis carolinensis. A freeze-fracture analysis of blood-brain barrier pathology

1979 • 41 citations

Cerebral Microembolization

1978 • 41 citations

CT contrast enhancement on brain scans and blood-CSF barrier disturbances in cerebral ischemic infarction.

1985 • 41 citations

Influence of blood–brain barrier opening to proteins on development of post-ischaemic brain injury

1986 • 41 citations

Morphofunctional Aspects of the Normal and Pathological Blood-Brain Barrier

1983 • 41 citations

The role of intracranial hypotension in neonatal intraventricular hemorrhage

1983 • 40 citations

Computed tomography for diagnosis and assessment of cerebral fat embolism

1983 • 39 citations

Indomethacin and cerebrovascular permeability to albumin in acute hypertension and cerebral embolism in the rat

1981 • 39 citations

CT in iatrogenic cerebral air embolism.

1986 • 38 citations

Blood-brain barrier impairment after cardiac resuscitation

1981 • 38 citations

Disturbances of the Blood-Brain Barrier in Cerebrovascular Disorders

1983 • 37 citations

Increased susceptibility to osmotic disruption of the blood-brain barrier in chronic hypertension.

1984 • 37 citations

The importance of cerebral arterioles in alterations of the blood-brain barrier.

1980 • 37 citations

Contrast enhancement of cerebral infarcts. Incidence and clinical value in different states of cerebral infarction

1982 • 37 citations

Cerebral Microembolization

1977 • 36 citations

Graded focal cerebral ischemia in the rat by unilateral carotid artery occlusion and elevated intracranial pressure: hemodynamic and biochemical characterization.

1985 • 36 citations

Computed tomography of intracerebral hematomas. II. Radionuclide and transmission CT studies of the perihematoma region

1977 • 34 citations

Ischemic injuries of the brain. Morphologic evolution.

1983 • 34 citations

Central nervous system anoxic-ischemic insult in children due to near-drowning.

1985 • 34 citations

Leukotriene C4 induces vasogenic cerebral edema in rats

1984 • 34 citations

Astrocytic Processes: A Route Between Vessels and Neurons Following Blood-Brain Barrier Injury

1975 • 34 citations

Effects of leukotriene C4 on the cerebral microvasculature

1986 • 32 citations

Brain Intracellular, pH, Blood Flow, and Blood—Brain Barrier Differences with Barbiturate and Halothane Anesthesia in the Cat

1980 • 32 citations

The distribution of ischaemic damage and cerebral blood flow after unilateral carotid occlusion and hypotension in the rat.

1984 • 32 citations

Increased vulnerability of the blood-brain barrier to experimental subarachnoid hemorrhage in spontaneously hypertensive rats.

1986 • 31 citations

A rabbit model of intracerebral hematoma

1985 • 31 citations

SERIAL BRAIN SCANNING WITH TECHNETIUM 99m PERTECHNETATE IN CEREBRAL INFARCTION

1969 • 31 citations

Changes in CSF blood-brain barrier parameters in ischaemic cerebral infarction

1983 • 31 citations

Central nervous system hypoxia in children due to near drowning.

1985 • 30 citations

β-adrenergic receptors in brain microvessels of diabetic rats

1984 • 28 citations

Cerebral circulation after cardiac arrest. Microangiographic and protein tracer studies.

1977 • 28 citations

Discrepancies among CT, histological, and blood-brain barrier findings in early cerebral ischemia

1986 • 28 citations

Effect of dexamethasone on serum protein extravasation in experimental brain infarcts of monkey: An immunohistochemical study

1985 • 28 citations

Cerebral vasospasm: a clinical observation.

1978 • 28 citations

Experimental delayed radiation necrosis of the brain

1979 • 26 citations

The Pathophysiology of Ischemic Brain Swelling

1985 • 25 citations

Modification of focal cerebral ischemia by prostacyclin and indomethacin

1983 • 25 citations

Cerebral air embolism and the blood-brain barrier in the rat

2009 • 25 citations

Ischaemic swelling of cerebral hemisphere in the gerbil.

1975 • 23 citations

Disruption of blood-brain barrier following bilateral carotid artery occlusion in spontaneously hypertensive rats. A quantitative study.

1983 • 23 citations

Relationship between Contrast Enhancement on Computed Tomography and Cerebral Vasospasm in Patients with Subarachnoid Hemorrhage

1983 • 22 citations

Radionuclide Sinography: Diagnosis of Lateral Sinus Thrombosis By Dynamic and Static Brain Imaging

1979 • 22 citations

Subarachnoid Enhancement Secondary to Subarachnoid Hemorrhage with Special Reference to the Clinical Significance and Pathogenesis

1982 • 21 citations

Blood-brain barrier integrity in patients with cerebral infarction investigated by computed tomography and serum-CSF-albumin

2009 • 21 citations

Neurogenic Control of Blood-Brain Barrier Permeability

1983 • 21 citations

Dose-dependent, amphetamine-induced changes in permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats

1980 • 19 citations

Radionuclide Imaging of the Brain

1986 • 19 citations

Clinical use of nuclear magnetic resonance imaging in stroke.

1986 • 18 citations

Brain Scans in Watershed Infarction and Laminar Cortical Necrosis

1972 • 17 citations

Mechanisms of contrast enhancement in cerebral infarction: computerized tomography, regional cerebral blood flow, fluorescein angiography, and pathological study.

1981 • 17 citations

Contrast medium accumulation and washout in canine brain tumors and irradiated normal brain: a CT study of kinetics.

1984 • 17 citations

Positron Emission Tomography with ⁶⁸Ga-Edta Compared with Transmission Computed Tomography in the Evaluation of Brain Infarcts

1981 • 16 citations

The "luxury-perfusion syndrome" following a cerebrovascular accident demonstrated by radionucleide angiography.

1974 • 16 citations

Mechanisms of Blood-Brain Barrier Breakdown After Microembolization of the Cat's Brain

1983 • 16 citations

Neurogenic modification of the vulnerability of the blood‐brain barrier during acute hypertension in conscious rats

1983 • 16 citations

Cholesterol crystal embolization in rat brain: a model for atheroembolic cerebral infarction.

1980 • 16 citations

Radiation effects in the canine brain evaluated by quantitative computed tomography.

1982 • 15 citations

Beagle puppy model of perinatal cerebral insults

1986 • 15 citations

Influence of blood pressure on blood-brain barrier function in brain ischemia

2009 • 15 citations

Reversibility of blood-brain barrier dysfunction in acute hypertension induced by angiotensin

1984 • 14 citations

Acute Cerebral Vascular Accident Associated with Hyperperfusion

1976 • 13 citations

Pathophysiology of the opening of the blood-brain and blood-cerebrospinal fluid barriers in acute hypertension

1984 • 13 citations

Urinary kallikrein response to acute saline or water loads in hypertensive and normal humans.

1984 • 12 citations

Carotid artery constriction in acute hypertension.

1981 • 11 citations

Vulnerability of Cerebral Venous Flow Following Middle Cerebral Arterial Occlusion in Cats

1983 • 10 citations

Sequential Assessment of Regional Cerebral Blood Flow, Regional Cerebral Blood Volume, and Blood—Brain Barrier in Focal Cerebral Ischemia: A Case Report

1986 • 9 citations

Cerebral Venous Thrombosis: Findings from Computer Tomography and Fluorescein Angiography

1983 • 9 citations

CT enhancement after prolonged high-dose contrast infusion in the early stage of cerebral infarction.

1986 • 9 citations

Tissue pertechnetate and iodinated contrast material in ischemic stroke.

1980 • 9 citations

Influence of respiratory stress and hypertension upon the blood-brain barrier

1980 • 8 citations

Cerebral changes during recirculation following temporary ischemia in mongolian gerbils, with special reference to blood-brain-barrier change

1977 • 8 citations

Effectiveness of contrast regimens in CT detection of vascular malformations of the brain.

1981 • 8 citations

Water and electrolyte content of rabbit brain after opening the blood-brain barrier by acute hypertension

1985 • 4 citations

[Cerebrospinal fluid in cerebrovascular disorders].

1973 • 3 citations

The Role of Cerebral Veins in the Genesis of Secondary Lesions in the Occipital Lobe

1983 • 3 citations

The permeability of the blood-brain barrier to protein in the post-hypoxic cerebral edema of the rat

1984 • 2 citations

The relationship of blood-brain barrier damage to survival time after acute radiation injury

1974 • 1 citations

Dissecting Abscess of the Falx Cerebri

1955 • 1 citations

The Venous Blood-Brain Barrier

1983 • 1 citations

POST ISCHEMIC EARLY PERMEABILITY CHANGES OF THE BLOOD BRAIN BARRIER(BBB)

1984 • 1 citations