Characterization of Hepatitis C Virus (HCV) and HCV E2 Interactions with CD81 and the Low-Density Lipoprotein Receptor

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets

2014 • 4,782 citations

Binding of Hepatitis C Virus to CD81

1998 • 2,042 citations

Viral Hepatitis and Liver Disease

1985 • 1,886 citations

A Role for Hepatitis C Virus Infection in Type II Cryoglobulinemia

1992 • 1,302 citations

Clinical Outcomes after Transfusion-Associated Hepatitis C

1995 • 1,228 citations

Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate

1997 • 1,023 citations

Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor

1999 • 947 citations

Hepatitis C: The clinical spectrum of disease

1997 • 768 citations

CD81 (TAPA-1): A MOLECULE INVOLVED IN SIGNAL TRANSDUCTION AND CELL ADHESION IN THE IMMUNE SYSTEM

1998 • 507 citations

Microbial adherence to and invasion through proteoglycans

1997 • 480 citations

Efficient infection of cells in culture by type O foot-and-mouth disease virus requires binding to cell surface heparan sulfate

1996 • 370 citations

Equilibrium centrifugation studies of hepatitis C virus: evidence for circulating immune complexes

1993 • 363 citations

Association of hepatitis C virus in human sera with ?-lipoprotein

1992 • 358 citations

Low density lipoprotein receptor as a candidate receptor for hepatitis C virus

1999 • 345 citations

Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line.

1992 • 328 citations

A27L Protein Mediates Vaccinia Virus Interaction with Cell Surface Heparan Sulfate

1998 • 328 citations

Deletion in the Gene for the Low-Density-Lipoprotein Receptor in a Majority of French Canadians with Familial Hypercholesterolemia

1987 • 300 citations

Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR

1995 • 258 citations

Cell-Surface Heparan Sulfate Proteoglycan Mediates HIV-1 Infection of T-Cell Lines

1993 • 254 citations

Peripheral blood leukocytes serve as a possible extrahepatic site for hepatitis C virus replication

1993 • 240 citations

Normal Lymphocyte Development but Delayed Humoral Immune Response in CD81-null Mice

1997 • 231 citations

Density heterogeneities of hepatitis C virus in human sera due to the binding of ?-lipoproteins and immunoglobulins

1993 • 228 citations

Structure-Function Analysis of Hepatitis C Virus Envelope-CD81 Binding

2000 • 222 citations

Association between hepatitis C virus and mixed cryoglobulinemia [see comment].

1991 • 209 citations

Detection of replicative intermediates of hepatitis C viral RNA in liver and serum of patients with chronic hepatitis C.

1991 • 207 citations

Hepatitis C virus: Detection of intracellular virus particles by electron microscop

1996 • 195 citations

Functional Analysis of Cell Surface-Expressed Hepatitis C Virus E2 Glycoprotein

1999 • 190 citations

Detection of Replicative Form of Hepatitis C Virus RNA in Peripheral Blood Mononuclear Cells

1992 • 184 citations

Hepatitis C Virus Is Detected in a Monocyte/Macrophage Subpopulation of Peripheral Blood Mononuclear Cells of Infected Patients

1992 • 183 citations

A role for hepatitis C virus infection in type II cryoglobulinemia Agnello V., Chung R.T., Kaplan L.M. N Engl J Med 1992;327:1490–1495

1993 • 168 citations

Hepatitis C: progress and problems

1994 • 162 citations

Correlation between the infectivity of hepatitis C virus in vivo and its infectivity in vitro.

1993 • 160 citations

Association between hepatitis C virus and mixed cryoglobulinemia

1991 • 157 citations

Hepatitis C virus: Buoyant density if the factor VIII‐derived isolate in sucrose

1991 • 156 citations

Visualization of hepatitis C virions and putative defective interfering particles isolated from low‐density lipoproteins

1996 • 151 citations

Characterization of monoclonal antibodies against human low density lipoprotein.

1983 • 149 citations

Posttransfusion non-A, non-B hepatitis in chimpanzees. Physicochemical evidence that the tubule-forming agent is a small, enveloped virus.

1985 • 139 citations

Cell Fusion Activity of Hepatitis C Virus Envelope Proteins

2000 • 129 citations

Posttransfusion non-A, non-B hepatitis in chimpanzees

1985 • 127 citations

In vitro infection of peripheral blood mononuclear cells by hepatitis C virus

1995 • 123 citations

Nonrandom Distribution of Hepatitis C Virus Quasispecies in Plasma and Peripheral Blood Mononuclear Cell Subsets

1999 • 119 citations

First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins.

1987 • 115 citations

Establishment of persistent hepatitis C virus infection and replication in vitro.

1997 • 109 citations

Binding of Hepatitis C Virus E2 Glycoprotein to CD81 Does Not Correlate with Species Permissiveness to Infection

2000 • 101 citations

CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses

1998 • 101 citations

Full-Length GB Virus C (Hepatitis G Virus) RNA Transcripts Are Infectious in Primary CD4-Positive T Cells

2000 • 100 citations

Role of the extracellular domain of human herpesvirus 7 glycoprotein B in virus binding to cell surface heparan sulfate proteoglycans

1997 • 89 citations

Characterization of Hepatitis G Virus (GB-C Virus) Particles: Evidence for a Nucleocapsid and Expression of Sequences Upstream of the E1 Protein

1998 • 72 citations

Distribution of Hepatitis C Virus (HCV) RNA in Whole Blood and Blood Cell Fractions: Plasma HCV RNA Analysis Underestimates Circulating Virus Load

1997 • 70 citations

Antibodies against hepatitis C virus in mixed cryoglobulinemia patients

1991 • 68 citations

Hepatitis C virus (HCV) infection and cryoglobulinemia: Analysis of whole blood and plasma HCV-RNA concentrations and correlation with liver histology

2000 • 59 citations

Rotaviruses induce an early membrane permeabilization of MA104 cells and do not require a low intracellular Ca2+ concentration to initiate their replication cycle

1997 • 55 citations

Suramin blocks hepatitis C binding to human hepatoma cells in vitro

1999 • 52 citations

Prospective Comparison of Whole-Blood- and Plasma-Based Hepatitis C Virus RNA Detection Systems: Improved Detection Using Whole Blood as the Source of Viral RNA

1999 • 50 citations

Proteins are cointernalized with virion particles during early infection

1987 • 48 citations

Modification of membrane permeability during semliki forest virus infection

1985 • 46 citations

Direct detection of hepatitis C virus (HCV) RNA from whole blood, and comparison with HCV RNA in plasma and peripheral blood mononuclear cells

1995 • 45 citations

Fluorescence-Based Quantitative Methods for Detecting Human Immunodeficiency Virus Type 1-Induced Syncytia

2000 • 25 citations

Visualization and characterization of GB virus‐C particles: evidence for a nucleocapsid

1999 • 17 citations