A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM

Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine

1993 • 6,407 citations

Basic principles of ROC analysis

1978 • 5,844 citations

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

A Prospective Study of Indexes Predicting the Outcome of Trials of Weaning from Mechanical Ventilation

1991 • 1,252 citations

Two genes encode distinct glutamate decarboxylases

1991 • 1,195 citations

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

1982 • 531 citations

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

1992 • 494 citations

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.

1992 • 487 citations

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.

1987 • 319 citations

Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10.

1991 • 281 citations

64 000 Mr autoantibodies as predictors of insulin-dependent diabetes

1990 • 208 citations

Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type.

1993 • 200 citations

The Swedish childhood diabetes study ? results from a nine year case register and a one year case-referent study indicating that Type 1 (insulin-dependent) diabetes mellitus is associated with both Type 2 (non-insulin-dependent) diabetes mellitus and autoimmune disorders

1989 • 190 citations

Antibodies to Glutamic Acid Decarboxylase Discriminate Major Types of Diabetes Mellitus

1992 • 154 citations

Immunology and Diabetes Workshops: report of the first international workshop on the standardisation of cytoplasmic islet cell antibodies

1986 • 147 citations

Plasmapheresis in the initial treatment of insulin-dependent diabetes mellitus in children.

1983 • 142 citations

Autoantibodies in IDDM primarily recognize the 65,000-M(r) rather than the 67,000-M(r) isoform of glutamic acid decarboxylase

1993 • 132 citations

Monoclonal antibodies to glutamic acid decarboxylase.

1986 • 129 citations

Islet cell and other organ-specific autoantibodies in all children developing Type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children

1989 • 129 citations

Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes.

1993 • 125 citations

Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble.

1991 • 118 citations

Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression.

1993 • 117 citations

Predictive value of islet cell and insulin autoantibodies for Type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children

1992 • 115 citations

Estimating Mortality Risk in Preperative Patients Using Immunologic, Nutritional, and Acute-Phase Response Variables

1989 • 115 citations

Serum exchange and use of dilutions have improved precision of measurement of islet cell antibodies

1988 • 113 citations

Differential Expression of Glutamic Acid Decarboxylase in Rat and Human Islets

1993 • 97 citations

Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.

1991 • 96 citations

Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes

1988 • 96 citations

Prolonged incubation in the two-colour immunofluorescence test increases the prevalence and titres of islet cell antibodies in Type 1 (insulin-dependent) diabetes mellitus

1987 • 95 citations

Recombinant Glutamic Acid Decarboxylase (Representing the Single Isoform Expressed in Human Islets) Detects IDDM-Associated 64,000-Mr Autoantibodies

1992 • 95 citations

Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

1993 • 78 citations

The Fourth International Serum Exchange Workshop to standardize cytoplasmic islet cell antibodies

1991 • 72 citations

Islet cell antibodies ? Theoretical and practical implications

1981 • 67 citations

Risk for developing Type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies

1991 • 52 citations

Autoantibodies to glutamic acid decarboxylase (GAD) detected by an immuno-trapping enzyme activity assay: Relation to insulin-dependent diabetes mellitus and islet cell antibodies

1991 • 49 citations

An ELISA for Antibodies to Recombinant Glutamic Acid Decarboxylase in IDDM

1992 • 40 citations

Immunology and Diabetes Workshops: Report of the Second International Workshop on the Standardisation of Cytoplasmic Islet Cell Antibodies

1987 • 37 citations

Islet cell antibodies in insulin-dependent (type 1) diabetic children treated with plasmapheresis.

1985 • 25 citations

Glutamic acid decarboxylase in insulin‐dependent diabetes mellitus

1992 • 25 citations