Radioimmunoassay Detects the Frequent Occurrence of Autoantibodies to the Mr 65,000 Isoform of Glutamic Acid Decarboxylase in Japanese Insulin-Dependent Diabetes

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Autoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiff-Man Syndrome

1990 • 618 citations

Antibodies to Glutamic Acid Decarboxylase Reveal Latent Autoimmune Diabetes Mellitus in Adults With a Non—Insulin-Dependent Onset of Disease

1993 • 548 citations

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

1982 • 531 citations

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.

1992 • 487 citations

A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM

1994 • 402 citations

Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus.

1988 • 371 citations

Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes

1990 • 356 citations

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.

1987 • 319 citations

Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10.

1991 • 281 citations

Detection of GAD65 Antibodies in Diabetes and Other Autoimmune Diseases Using a Simple Radioligand Assay

1994 • 261 citations

Immunogenetic and Clinical Characterization of Slowly Progressive IDDM

1993 • 251 citations

High Concentration of GABA and High Glutamate Decarboxylase Activity in Rat Pancreatic Islets and Human Insulinoma

1976 • 235 citations

64 000 Mr autoantibodies as predictors of insulin-dependent diabetes

1990 • 208 citations

Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type.

1993 • 200 citations

Antibodies to Glutamic Acid Decarboxylase Discriminate Major Types of Diabetes Mellitus

1992 • 154 citations

Autoantibodies to a 64-Kilodalton Islet Cell Protein Precede the Onset of Spontaneous Diabetes in the BB Rat

1984 • 147 citations

Life-Table Analysis of Progression to Diabetes of Anti-Insulin Autoantibody-Positive Relatives of Individuals With Type I Diabetes

1989 • 141 citations

Autoantibodies to Glutamic Acid Decarboxylase in Patients with IDDM and Autoimmune Thyroid Disease

1994 • 132 citations

Autoantibodies in IDDM primarily recognize the 65,000-M(r) rather than the 67,000-M(r) isoform of glutamic acid decarboxylase

1993 • 132 citations

Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression.

1993 • 117 citations

Serum exchange and use of dilutions have improved precision of measurement of islet cell antibodies

1988 • 113 citations

Prognostically Significant Heterogeneity of Cytoplasmic Islet Cell Antibodies in Relatives of Patients with Type I Diabetes

1992 • 107 citations

Distinct cytoplasmic islet cell antibodies with different risks for Type 1 (insulin-dependent) diabetes mellitus

1992 • 104 citations

High Frequency of Aspartic Acid at Position 57 of HLA-DQ β-Chain in Japanese IDDM Patients and Nondiabetic Subjects

1990 • 103 citations

Differential Expression of Glutamic Acid Decarboxylase in Rat and Human Islets

1993 • 97 citations

Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.

1991 • 96 citations

Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes

1988 • 96 citations

Recombinant Glutamic Acid Decarboxylase (Representing the Single Isoform Expressed in Human Islets) Detects IDDM-Associated 64,000-Mr Autoantibodies

1992 • 95 citations

HLA-DQ system and insulin-dependent diabetes mellitus in Japanese: does it contribute to the development of IDDM as it does in Caucasians?

1988 • 95 citations

Autoantibodies in Nonobese Diabetic Mice Immunoprecipitate 64,000-Mr Islet Antigen

1988 • 86 citations

High Level of Concordance Between Assays for Glutamic Acid Decarboxylase Antibodies: The First International Glutamic Acid Decarboxylase Antibody Workshop

1994 • 80 citations

Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

1993 • 78 citations

The Fourth International Serum Exchange Workshop to standardize cytoplasmic islet cell antibodies

1991 • 72 citations

The Exon-Intron Organization of the Genes (GAD1 and GAD2) Encoding Two Human Glutamate Decarboxylases (GAD67 and GAD65) Suggests That They Derive from a Common Ancestral GAD

1994 • 70 citations

Glutamic acid decarboxylase (GAD) autoantibodies are additional predictive markers of Type 1 (insulin-dependent) diabetes mellitus in high risk individuals

1992 • 68 citations

Inducement by Fat Feeding of Basal Hyperglycemia in Rats With Abnormal β-Cell Function: Model for Study of Etiology and Pathogenesis of NIDDM

1990 • 62 citations

Microdetermination of Free Amino Acids in Pancreatic Islets Isolated from Obese‐Hyperglycemic Mice

1972 • 57 citations

The ethnic distribution of antibodies to glutamic acid decarboxylase: Presence and levels in insulin-dependent diabetes mellitus in Europid and Asian subjects

1993 • 53 citations

Persistence of Serum Antibodies to 64,000-Mr Islet Cell Protein After Onset of Type 1 Diabetes

1990 • 53 citations

Risk for developing Type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies

1991 • 52 citations

Antibodies to glutamic acid decarboxylase are associated with HLA-DR genotypes in both Australians and Asians with Type 1 (insulin-dependent) diabetes mellitus

1992 • 48 citations

Antibodies to Glutamic Acid Decarboxylase in At-risk and Clinical Insulin-dependent Diabetic Subjects: Relationship to Age, Sex and Islet Cell Antibody Status, and Temporal Profile

1994 • 46 citations

Strong Association of HLA-DR3/DRw9 Heterozygosity With Early-Onset Insulin-Dependent Diabetes Mellitus in Chinese

1987 • 44 citations