N-terminal cleavage of Bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes Bcl-2-independent cytochrome C release and apoptotic cell death

Mitochondria and Apoptosis

1998 • 8,909 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Calpain and caspase: can you tell the difference?

2000 • 911 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

A different genetic code in human mitochondria

1979 • 558 citations

p53 Induces Apoptosis by Caspase Activation through Mitochondrial Cytochrome c Release

2000 • 553 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

1997 • 489 citations

Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling

1999 • 473 citations

Caspase-3-dependent Cleavage of Bcl-2 Promotes Release of Cytochrome c

1999 • 461 citations

Bax degradation by the ubiquitin/proteasome-dependent pathway: Involvement in tumor survival and progression

2000 • 439 citations

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

1996 • 427 citations

Low molecular weight heparins: prophylaxis of venous thromboembolism in surgical patients.

1997 • 399 citations

The role of the ubiquitin-proteasome pathway in apoptosis

1999 • 382 citations

Calpain: A Protease in Search of a Function?

1998 • 352 citations

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.

1996 • 351 citations

Bax cleavage is mediated by calpain during drug-induced apoptosis

1998 • 330 citations

Functional Consequences of the Sustained or Transient Activation by Bax of the Mitochondrial Permeability Transition Pore

1999 • 295 citations

Caspase-Mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during Apoptosis

1998 • 270 citations

Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin?

1992 • 236 citations

Cell-penetrating inhibitors of calpain

1991 • 224 citations

Caspase-dependent Activation of Calpain during Drug-induced Apoptosis

1999 • 206 citations

Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 beta-converting enzyme-like protease as candidate.

1996 • 204 citations

Cleavage of the calpain inhibitor, calpastatin, during apoptosis

1998 • 202 citations

Calpain, an upstream regulator of thymocyte apoptosis.

1997 • 191 citations

Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2

1998 • 189 citations

Calpain activation is upstream of caspases in radiation-induced apoptosis

1998 • 181 citations

Procaspase-3 and Poly(ADP)ribose Polymerase (PARP) Are Calpain Substrates

1999 • 180 citations

A novel aspect of calpain activation

1998 • 176 citations

Degradation of Retinoblastoma Protein in Tumor Necrosis Factor- and CD95-induced Cell Death

1997 • 170 citations

Death by design: mechanism and control of apoptosis

1999 • 169 citations

Proteasome inhibitors as potential novel anticancer agents

1999 • 157 citations

The Endoplasmic Reticulum Chaperone Glycoprotein GRP94 with Ca2+-binding and Antiapoptotic Properties Is a Novel Proteolytic Target of Calpain during Etoposide-induced Apoptosis

1999 • 139 citations

Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2.

1999 • 132 citations

Calpain and calpastatin regulate neutrophil apoptosis

1999 • 129 citations

Protein translocation in apoptosis

1999 • 96 citations

Reovirus-Induced Apoptosis Is Preceded by Increased Cellular Calpain Activity and Is Blocked by Calpain Inhibitors

1999 • 91 citations

Regulation of the calpain-calpastatin system by membranes (Review)

1996 • 81 citations

Characterization of interior cleavage of retinoblastoma protein in apoptosis

1997 • 51 citations

Bcl-2- and CrmA-inhibitable dephosphorylation and cleavage of retinoblastoma protein during etoposide-induced apoptosis.

1998 • 10 citations