Astroglia from defined brain regions as studied with primary cultures

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT

1969 • 1,680 citations

Differentiated Rat Glial Cell Strain in Tissue Culture

1968 • 1,480 citations

Fine structural localization of glutamine synthetase in astrocytes of rat brain

1979 • 1,318 citations

An acidic protein isolated from fibrous astrocytes

1971 • 1,192 citations

Advances in biochemical psychopharmacology

1970 • 1,186 citations

Glutamine Synthetase: Glial Localization in Brain

1977 • 1,170 citations

THE QUANTITATIVE HISTOCHEMISTRY OF THE RETINA

1956 • 928 citations

Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture

1978 • 813 citations

Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture

1979 • 805 citations

Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures.

1972 • 760 citations

Trophic Interactions Between Astroglial Cells and Hippocampal Neurons in Culture

1980 • 672 citations

Synaptic plasma membranes from rat brain synaptosomes: Isolation and partial characterization

1971 • 634 citations

Functional interactions between neurons and astrocytes I. Turnover and metabolism of putative amino acid transmitters

1979 • 622 citations

Physiological properties of glial cells in the central nervous system of amphibia.

1966 • 594 citations

Beta adrenergic receptor binding in membrane preparations from mammalian brain.

1976 • 576 citations

Biochemical evidence for glutamate as neurotransmitter in corticostriatal and corticothalamic fibres in rat brain

1981 • 547 citations

Astrocyte‐specific protein and neuroglial differentiation. An immunofluorescence study with antibodies to the glial fibrillary acidic protein

1974 • 493 citations

GLIA IN THE LEECH CENTRAL NERVOUS SYSTEM: PHYSIOLOGICAL PROPERTIES AND NEURON-GLIA RELATIONSHIP

1964 • 482 citations

Glial Cell Function: Uptake of Transmitter Substances

1971 • 460 citations

THE REGIONAL AND SUBCELLULAR DISTRIBUTION OF 2′,3′‐CYCLIC NUCLEOTIDE 3′‐PHOSPHOHYDROLASE IN THE CENTRAL NERVOUS SYSTEM

1967 • 458 citations

Simultaneous determination of beta-1 and beta-2-adrenergic receptors in tissues containing both receptor subtypes.

1979 • 418 citations

Increases in cortical depth and glia numbers in rats subjected to enriched environment

1966 • 410 citations

Excitatory amino acids directly depolarize rat brain astrocytes in primary culture

1984 • 358 citations

Axonal migration of proteins in the central nervous system and peripheral nerves as shown by radioautography

1963 • 354 citations

Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism.

1981 • 352 citations

Dynamic properties of glia cells

1979 • 344 citations

UPTAKE AND METABOLISM OF GLUTAMATE IN ASTROCYTES CULTURED FROM DISSOCIATED MOUSE BRAIN HEMISPHERES

1977 • 343 citations

Glial heterogeneity may define the three-dimensional shape of mouse mesencephalic dopaminergic neurones

1984 • 326 citations

Morphological and biochemical maturation of neurones cultured in the absence of glial cells

1979 • 325 citations

Histamine as a Neurotransmitter in Mammalian Brain: Neurochemical Evidence

1980 • 284 citations

Effect of striatal cells on in vitro maturation of mesencephalic dopaminergic neurones grown in serum-free conditions

1980 • 281 citations

The Ferrier Lecture - Neuroglial cells: physiological properties and a potassium mediated effect of neuronal activity on the glial membrane potential

1967 • 281 citations

On the Role of Glial Cells in the Mammalian Nervous System

1974 • 277 citations

Growth of purified astrocytes in a chemically defined medium.

1981 • 268 citations

Müller cell localisation of glutamine synthetase in rat retina

1977 • 265 citations

Direct identification and characterisation of β-adrenergic receptors in rat brain

1975 • 246 citations

The characterisation of [3H]GABA uptake into the satellite glial cells of rat sensory ganglia

1974 • 246 citations

A glial protein specific for the nervous system.

1966 • 234 citations

Autoradiographic localisation of [3H]GABA and [3H]glutamate over satellite glial cells

1974 • 230 citations

The in vitro differentiation of a bipotential glial progenitor cell.

1984 • 227 citations

Electrophysiology of Neuroglia

1975 • 225 citations

Preparation of enriched fractions from cerebral cortex containing isolated, metabolically active neuronal and glial cells

1967 • 215 citations

Kinetic characteristics of the glutamate uptake into normal astrocytes in cultures

1978 • 213 citations

Towards an improved serum-free, chemically defined medium for long-term culturing of cerebral cortex tissue

1984 • 211 citations

Some properties of unresponsive cells in the cerebral cortex

1967 • 209 citations

Aspartate, glutamate and γ-aminobutyric acid depolarize cultured astrocytes

1984 • 209 citations

PROTEIN TURNOVER IN CELL‐ENRICHED FRACTIONS FROM RABBIT BRAIN¹

1969 • 209 citations

Neuroglia: Biophysical Properties and Physiologic Function

1970 • 209 citations

Astrocyte-specific protein and radial glia in the cerebral cortex of newborn rat

1974 • 208 citations

Morphological and Biochemical Alterations in Foetal Rat Brain Cells cultured in the Presence of Monobutyryl Cyclic AMP

1973 • 203 citations

RELEASE OF [³H]GAMMA-AMINOBUTYRIC ACID FROM GLIAL CELLS IN RAT DORSAL ROOT GANGLIA.

1974 • 194 citations

Growth and differentiation of aggregating fetal brain cells in a serum-free defined medium

1979 • 189 citations

DETERMINANTS FOR THE ESTABLISHMENT OF PERMANENT TISSUE CULTURE LINES FROM HUMAN GLIOMAS

1973 • 189 citations

Uptake and metabolism of GABA in astrocytes cultured from dissociated mouse brain hemispheres

1977 • 186 citations

Demonstration of Enolase Activity Connected to the Brain‐Specific Protein 14‐3‐2

1975 • 177 citations

Quantitative Assay of Compounds in Isolated, Fresh Nerve Cells and Glial Cells from Control and Stimulated Animals

1959 • 168 citations

Regulation of Adenosine 3′:5′-Cyclic Monophosphate Concentration in Cultured Human Astrocytoma Cells by Catecholamines and Histamine

1971 • 168 citations

Characterization of uptake and release processes ford- andl-aspartate in primary cultures of astrocytes and cerebellar granule cells

1983 • 166 citations

Primary astrocyte cultures?a key to astrocyte function

1983 • 164 citations

Enzymatic and morphological properties of primary rat brain astrocyte cultures, and enzyme development in vivo

1978 • 161 citations

2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHOHYDROLASE IN THE DEVELOPING CHICK BRAIN AND SPINAL CORD

1968 • 153 citations

DISSOCIATED BRAIN CELLS IN PRIMARY CULTURES

1977 • 152 citations

Evidence for the existence of receptor--receptor interactions in the central nervous system. Studies on the regulation of monoamine receptors by neuropeptides.

1983 • 150 citations

Regulation by secretin, vasoactive intestinal peptide, and somatostatin of cyclic AMP accumulation in cultured brain cells.

1980 • 149 citations

Variability of the effects of serum-free medium, dibutyryl-cyclic AMP or theophylline on the morphology of cultured new-born rat astroblasts

1975 • 149 citations

Two forms of cerebellar glial cells interact differently with neurons in vitro.

1984 • 148 citations

High-Affinity Uptake of Serotonin Into Immunocytochemically Identified Astrocytes

1985 • 147 citations

Neuropeptides modulate the β-adrenergic response of purified astrocytes in vitro

1983 • 147 citations

Alpah-adrenergic receptor modulation of beta-adrenergic, adenosine and prostaglandin E1 increased adenosine 3':5'-cyclic monophosphate levels in primary cultures of glia.

1978 • 146 citations

Cellular Localization and Regulation of Glutamine Synthetase in Primary Cultures of Brain Cells from Newborn Mice

1981 • 141 citations

Cation transport and membrane potential properties of primary astroglial cultures from neonatal rat brains

1979 • 139 citations

Activation of Muscarinic and of α₁‐Adrenergic Receptors on Astrocytes Results in the Accumulation of Inositol Phosphates

1985 • 136 citations

Immunocytochemical localization of glycerol-3-phosphate dehydrogenase in rat oligodendrocytes

1980 • 135 citations

Action and uptake of neurotransmitters in cns tissue culture

1978 • 133 citations

Glial fibrillary acidic protein in primary astroglial cell cultures derived from newborn rat brain

1977 • 130 citations

Dopamine and norepinephrine uptake and metabolism by astroglial cells in culture

1981 • 124 citations

Cultivation of mouse cerebellar cells in serum free, hormonally defined media: Survival of neurons

1982 • 121 citations

Cellular composition of primary cultures from cerebral cortex, striatum, hippocampus, brainstem and cerebellum

1984 • 121 citations

Effects of Neurohormones on Glial Cells

1980 • 120 citations

Electrically induced release of acetylcholine from denervated Schwann cells

1974 • 118 citations

Growth and Differentiation of Neural Cells in Defined Media

1985 • 117 citations

Cellular location of the uptake of some amino acids into the rabbit retina

1972 • 116 citations

Differences in glutamate uptake in astrocytes cultured from different brain regions

1979 • 113 citations

A MODIFIED PROCEDURE FOR ISOLATION OF ASTROCYTE‐ AND NEURON‐ENRICHED FRACTIONS FROM RAT BRAIN

1978 • 111 citations

Taurine uptake in astrocytes cultured from dissociated mouse brain hemispheres

1976 • 100 citations

Regulation of Cyclic AMP Accumulation by Peptide Hormone Receptors in Immunocytochemically: Defined Astroglial Cells

1984 • 97 citations

ADRENERGIC α‐ AND β‐RECEPTORS EXPRESSED BY THE SAME CELL TYPE IN PRIMARY CULTURE OF PERINATAL MOUSE BRAIN

1978 • 96 citations

Novel neuron-related regulatory mechanisms for astrocytic glutamate and GABA high affinity uptake

1983 • 96 citations

The uptake ofl-glutamate by the retina

1976 • 95 citations

Cultured astrocytes from a syncytium after maturation

1985 • 94 citations

Factors influencing astrocyte growth and development in defined media

1984 • 94 citations

NEURONAL AND GLIAL SYSTEMS FOR γ‐AMINOBUTYRIC ACID TRANSPORT

1975 • 94 citations

Comparative ultrastructural study of the effects of serum-free medium and dibutyryl-cyclic AMP on newborn rat astroblasts

1976 • 94 citations

Occurrence and function of amines in endocrine cells producing polypeptide hormones.

1973 • 93 citations

Adenosine cyclic 3',5'-monophosphate in fetal rat brain cell cultures. I. Effect of catecholamines.

1972 • 92 citations

PROTEIN SYNTHESIS IN NEURONS AND GLIAL CELLS OF THE DEVELOPING RAT BRAIN: AN IN VIVO STUDY¹

1971 • 92 citations

Evidence for the existence of α- and β-adrenoceptors on cultured glial cells—an electrophysiological study

1982 • 91 citations

Propagation of human fetal spongioblasts and astrocytes in dispersed cell cultures

1965 • 89 citations

Application of cytochemical techniques to the study of suspected transmitter substances in the nervous system.

1972 • 88 citations

Pharmacological evidence that the non-neuronal diazepam binding site in primary cultures of glial cells is associated with a calcium channel

1985 • 88 citations

GLIAL CELL LINES

1977 • 88 citations

Development, morphology, and regional specialization of astrocytes

1986 • 86 citations

Differentiation of Aggregating Brain Cell Cultures

1973 • 85 citations

Cellular heterogeneity in primary cultures of brain cells revealed by immunocytochemical localization of glutamine synthetase

1984 • 85 citations

Preparation of Enriched Fractions from Cerebral Cortex containing Isolated, Metabolically Active Neuronal Cells

1965 • 84 citations

Possible relationship between glial cells, dopamine and the effects of antipsychotic drugs

1977 • 82 citations

High‐Affinity Uptake of [³H]Norepinephrine by Primary Astrocyte Cultures and Its Inhibition by Tricyclic Antidepressants

1983 • 81 citations

Evidence for net uptake of GABA into mouse astrocytes in primary cultures?Its sodium dependence and potassium independence

1978 • 80 citations

Evidence for the existence of histamine H1- and H2-receptors on astrocytes of cultured rat central nervous system

1984 • 80 citations

Neurons and glia in neural cultures

1975 • 80 citations

Localization of high affinity [3H]glycine transport sites in the cerebellar cortex

1981 • 78 citations

Amino acid and monoamine transport in primary astroglial cultures from defined brain regions

1985 • 78 citations

LEVELS AND INTRACELLULAR LOCALIZATION OF GLUTAMATE DECARBOXYLASE AND γ‐AMINOBUTYRATE TRANSAMINASE AND OTHER ENZYMES DURING THE DEVELOPMENT OF THE BRAIN*

1965 • 78 citations

Brain primary culture — a characterization

1980 • 77 citations

Fine structure of cultured glioblasts before and after stimulation by a Glia Maturation Factor

1977 • 75 citations

CHARACTERISTICS OF GLUTAMINE vs GLUTAMATE TRANSPORT IN ISOLATED GLIA AND SYNAPTOSOMES

1979 • 74 citations

Glial metabolism: alteration by potassium levels comparable to those during neural activity

1973 • 73 citations

Cellular localization of peptides in neural structures

1980 • 73 citations

Distribution of glial fibrillary acidic protein and fibronectin in primary astroglial cultures from rat brain

1980 • 72 citations

Effects of dibutyryl cyclic AMP and prostaglandin E 1 on cultured human glioma cells

1974 • 69 citations

Neurotransmitter Regulation of Adenosine 3′,5′-Monophosphate in Clonal Nerve, Glia, and Muscle Cell Lines

1976 • 68 citations

Ionic mechanism of a hyperpolarizing 5-hydroxytryptamine effect on leech neuropile glial cells

1982 • 68 citations

Electrical responses of astrocytic glia from the mammalian central nervous system cultivatedin vitro

1958 • 68 citations

Observations on cell growth and regulation of glutamine synthetase by dexamethasone in primary cultures of forebrain and cerebellar astrocytes

1985 • 67 citations

Serotonin receptors on astrocytes in primary cultures: Effects of methysergide and fluoxetine

1979 • 67 citations

beta-Adrenergic receptors in rat brain.

1976 • 66 citations

Changes in the Uptake of GABA and Taurine During Neuronal and Glial Maturation

1980 • 65 citations

Catechol-O-ethyl transferase and monoamine oxidase activity in cultured rodent astrocytoma cells

1972 • 65 citations

Cellular and subcellular distribution of the S-100 protein in rabbit and rat central nervous system

1976 • 65 citations

Bulk Separation of Neuronal Cell Bodies and Glial Cells in the Absence of Added Digestive Enzymes

1974 • 63 citations

Neuroglia Electrically Coupled to Neurons

1969 • 62 citations

Cultivation of immature astrocytes of mouse cerebellum in a serum-free, hormonally defined medium. Appearance of the mature astrocytic phenotype after addition of serum

1982 • 62 citations

Interaction of Neuropeptides and Cultured Glial (Müller) Cells of the Chick Retina: Elevation of Intracellular Cyclic AMP by Vasoactive Intestinal Peptide and Glucagon

1984 • 60 citations

Is there a ?dopaminergic glial cell??

1984 • 60 citations

Chemically defined medium for rat astroglial cells in primary culture

1984 • 60 citations

THE DEVELOPMENT OF D‐AMINO ACID OXIDASE IN RAT CEREBELLUM

1977 • 57 citations

Factors influencing the effect of hormones on the accumulation of cyclic AMP in cultured human astrocytoma cells

1975 • 56 citations

SUBSTRATE AND INHIBITOR‐RELATED CHARACTERISTICS OF MONOAMINE OXIDASE IN C6 RAT GLIAL CELLS

1976 • 56 citations

Electrical and pharmacological properties of mammalian neuroglial cells in tissue-culture

1966 • 55 citations

Stimulation of proliferation and maturation of rat astroblasts in serum‐free culture by an astroglial growth factor

1982 • 54 citations

Muscarinic acetylcholine receptors on cultured glia cells

1982 • 53 citations

GABA metabolism in cultured glial cells

1979 • 52 citations

Accumulation of putative amino acid neurotransmitters, monoamines and d-Ala2-Met-enkephalinamide in primary astroglial cultures from various brain areas, visualized by autoradiography

1983 • 49 citations

On GABA metabolism in the gliocyte cells of the rat pineal gland

1975 • 48 citations

Extracellular fluid proteins of goldfish brain: Studies of concentration and labeling patterns

1981 • 47 citations

The localization of alkaline phosphatase activity in cerebral blood vessels

1963 • 46 citations

Morphological and biochemical differentiation of glial cells in primary culture

1980 • 46 citations

MAO, COMT, and GABA‐T Activities in Primary Astroglial Cultures

1983 • 46 citations

Regulation of cyclic GMP, cyclic AMP and lactate dehydrogenase by putative neurotransmitters in the C6 rat glioma cell line

1978 • 45 citations

Cellular composition of a cerebral hemisphere primary culture

1984 • 43 citations

Preparation and properties of the brain specific protein 14-3-2

1977 • 43 citations

Enzyme activities of monoamine oxidase, cathechol-o-methyltransferase and ?-aminoubutyric acid transaminase in primary astroglial cultures and adult rat brain from different brain regions

1984 • 43 citations

Brain primary culture — A characterization (part II)

1982 • 43 citations

Interactions between neurons and astrocytes in the turnover of GABA and glutamate

1980 • 42 citations

Uptake of biogenic amines by glial cells in culture I. A neuronal-like transport system for serotonin

1978 • 41 citations

Biliary transport maximum of tauroursodeoxycholate is twice as high as that of taurocholate in the rat

1981 • 41 citations

Surface culture of fetal mammalian brain cells: Effect of subculture on morphology and choline acetyltransferase activity

1973 • 40 citations

Autoradiographic studies on the uptake of 3H-noradrenaline and 3H-GABA in cultured rat cerebellum

1976 • 40 citations

Reactive Microglia with Membrane Features of Mononuclear Phagocytes

1976 • 38 citations

Embryonic cerebellar astroglia in vitro

1984 • 37 citations

REGIONAL UTILIZATION OF LEUCINE-H³ BY NORMAL RAT BRAIN: MICRODENSITOMETRIC EVALUATION OF AUTORADIOGRAMS

1963 • 36 citations

Incorporation of [3H]2-deoxyglucose into glycogen in nervous tissues

1982 • 36 citations

Glial control of neuronal excitability in mammals : I. Electrophysiological and isotopic evidence in culture

1980 • 35 citations

Transport of monoamine and amino acid neurotransmitters by primary astroglial cultures

1985 • 34 citations

The Bulk Separation of Neuroglia and Neuron Perikarya

1972 • 33 citations

Modification of taurine and hypotaurine uptake systems in cultured primary astrocytes by serum‐free medium and dibutyryl cyclic AMP treatment

1984 • 33 citations

Primary cultures from defined brain areas. III. Effects of seeding time on [3H]l-glutamate transport and glutamine synthetase activity

1986 • 33 citations

Properties of [3H]Diazepam binding sites on cultured murine glia and neurons

1984 • 31 citations

Electrical response of glioma cells to acetylcholine

1976 • 31 citations

Primary cultures from defined brain areas; effects of seeding time on cell growth, astroglial content and protein synthesis

1985 • 30 citations

Biogenic amine-sensitive adenylate cyclases in primary culture of neuronal or glial cells from mesencephalon

1984 • 30 citations

Efflux of potassium from neurones excited by glutamate and aspartate causes a depolarization of cultured glial cells

1981 • 29 citations

Primary astroglial cultures

1986 • 29 citations

Primary cultures from defined brain areas; effects of seeding time on the development of β-adrenergic- and dopamine-stimulated cAMP-activity during cultivation

1985 • 28 citations

Techniques for Separation of Neurons and Glia and Their Application to Metabolic Studies

1975 • 27 citations

Co-cultivation of astroglial enriched cultures from striatum and neuronal containing cultures from substantia nigra

1986 • 26 citations

Development of β-adrenergic receptors and their function in glia-neuron communication in cultured chick brain

1983 • 26 citations

Depolarization of cultured astrocytes by glutamate and aspartate

1979 • 26 citations

Adenyl cyclase in neuronal and glial-enriched fractions from rat and rabbit brain.

1973 • 26 citations

NUTRITIONAL REQUIREMENTS OF CELLS IN CULTURE, WITH SPECIAL REFERENCE TO NEURAL CELLS

1977 • 25 citations

Glutamine synthetase activity in vivo and in primary cell cultures of rat hypothalamus

1979 • 24 citations

CELL DENSITY AND RECEPTOR-ADENYLATE CYCLASE RELATIONSHIPS IN THE C-6 RAT ASTROCYTOMA CELL

1977 • 22 citations

Protein synthesis by astrocytes in primary cultures

1981 • 22 citations

Co-cultivation of astroglial and neuronal primary cultures from rat brain

1986 • 22 citations

Cortical astrocytes in primary culture: presence of neurotransmitter-binding sites

1985 • 22 citations

Uptake of3H-noradrenaline and3H-5-hydroxytryptamine in cultured rat brainstem

1975 • 21 citations

Growth and morphology of neuronal cell lines cultured in perfusion

1983 • 21 citations

Drug-induced alterations in morphology and level of cAMP in cultured human glioma cells

1975 • 20 citations

Glial Transport of Amino Acid Neurotransmitter Candidates

1975 • 19 citations

Factors influencing the growth and respiration of rat cerebral astrocytes in primary culture

1981 • 18 citations

Neurons and Glia: Separation Techniques and Biochemical Interrelationships

1969 • 17 citations

Glial uptake of monoamines in primary cultures of rat median raphe nucleus and cerebellum

1981 • 16 citations

The Germinal Cell and Histogenesis of the Nervous System

1978 • 16 citations

GABA-Transaminase of Mammalian Brain

1979 • 15 citations

Glial-released proteins in neural intercellular communication: molecular mapping, modulation, and influence on neuronal differentiation.

1982 • 14 citations

14-3-2 protein in rat brain

1978 • 12 citations

Age-dependent utilization of phenylalanine for the synthesis of neuronal and glial proteins.

1973 • 12 citations

ELECTROPHYSIOLOGICAL AND HISTOCHEMICAL PROPERTIES OF FETAL HUMAN SPINAL CORD IN TISSUE CULTURE

1974 • 11 citations

Amino acid incorporation during morphine intoxication. II: Electrophoretic separation of extracellular proteins from cerebral hemisphere slices and astroglia-enriched primary cultures

1985 • 10 citations

Protein metabolism in an astroglial primary culture

1983 • 9 citations

ASTROCYTES IN THE CEREBRAL CORTEX WITH SPECIAL REGARD TO TISSUE CULTURE STUDIES

1986 • 7 citations

Protein metabolism and electrophoretic profiles in astroglial primary cultures from different regions of newborn rat brain

1986 • 6 citations

Acidic Protein in Macrophages

1981 • 4 citations

Alpha- and beta-adrenoceptors on cultured glial cells.

1983 • 4 citations

cAMP accumulation in developing cultures of chicken embryo brain hemisphera.

1980 • 3 citations