Functional interactions between neurons and astrocytes I. Turnover and metabolism of putative amino acid transmitters

SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

1944 • 2,580 citations

Mode of cell migration to the superficial layers of fetal monkey neocortex

1972 • 2,145 citations

Chemical Nature of Synaptic Transmission in Vertebrates

1974 • 1,613 citations

Fine structural localization of glutamine synthetase in astrocytes of rat brain

1979 • 1,318 citations

Advances in biochemical psychopharmacology

1970 • 1,186 citations

Glutamine Synthetase: Glial Localization in Brain

1977 • 1,170 citations

Amino acid transmitters in the mammalian central nervous system

1974 • 1,169 citations

GABA in nervous system function

1977 • 1,087 citations

The role of calcium in the release of neurotransmitter substances and hormones.

1970 • 871 citations

THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS

1960 • 853 citations

CHOLINERGIC AND NON‐CHOLINERGIC NERVE ENDINGS IN RAT BRAIN–I

1962 • 784 citations

Metabolism of amino-acids

1935 • 760 citations

γ-AMINOBUTYRIC ACID IN BRAIN: ITS FORMATION FROM GLUTAMIC ACID

1950 • 679 citations

Iontophoretic studies of neurones in the mammalian cerebral cortex

1963 • 659 citations

The action of γ-Aminobutyric acid on cortical neurones

1967 • 612 citations

Gamma-Aminobutyric Acid Binding to Receptor Sites in the Rat Central Nervous System

1974 • 589 citations

The isolation and characterization of acetylcholine-containing particles from brain

1959 • 570 citations

Calcium transport in contraction and secretion

1975 • 567 citations

Uptake and metabolism of γ-aminobutyric acid by neurones and glial cells

1975 • 564 citations

The formation from the schwann cell surfaceof myelin in the peripheral nerves of chick embryos

1954 • 541 citations

SUBCELLULAR DISTRIBUTION OF THE ENZYMES OF THE GLUTAMIC ACID, GLUTAMINE AND γ‐AMINOBUTYRIC ACID CYCLES IN RAT BRAIN*

1965 • 539 citations

The mechanism and applications of Leão's spreading depression of electroencephalographic activity

1974 • 518 citations

A glutamatergic corticostriatal path?

1977 • 487 citations

The chemical excitation of spinal neurones by certain acidic amino acids

1960 • 484 citations

High affinity uptake of glutamate in terminals of corticostriatal axons

1977 • 480 citations

High affinity uptake systems for glycine, glutamic and aspartic acids in synaptosomes of rat central nervous tissues

1972 • 476 citations

The application of subcellular fractionation techniques to the study of brain function

1965 • 466 citations

Glial Cell Function: Uptake of Transmitter Substances

1971 • 460 citations

Transport and Metabolism of Glutamate and Gaba in Neurons and Glial Cells

1981 • 437 citations

MECHANISM OF SPREADING CORTICAL DEPRESSION

1956 • 437 citations

Markers for Gene Expression in Cultured Cells from the Nervous System

1972 • 403 citations

Metabolic Compartmentation in the Brain

1973 • 387 citations

GLUTAMINE—A MAJOR SUBSTRATE FOR NERVE ENDINGS

1978 • 380 citations

DISTRIBUTION OF SOME SYNAPTIC TRANSMITTER SUSPECTS IN CAT SPINAL CORD: GLUTAMIC ACID, ASPARTIC ACID, γ‐AMINOBUTYRIC ACID, GLYCINE, AND GLUTAMINE *

1967 • 373 citations

Studies of the uptake of3H-GABA and [3H]glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography

1972 • 371 citations

Cell, Tissue, and Organ Cultures in Neurobiology

1977 • 346 citations

THE CONCENTRATIONS OF FREE AMINO ACIDS AND OTHER ELECTROLYTES IN CEREBROSPINAL FLUID, IN VIVO DIALYSATE OF BRAIN, AND BLOOD PLASMA OF THE DOG*

1966 • 345 citations

Dynamic properties of glia cells

1979 • 344 citations

Glutamic acid: Selective depletion by viral induced granule cell loss in hamster cerebellum

1974 • 344 citations

UPTAKE AND METABOLISM OF GLUTAMATE IN ASTROCYTES CULTURED FROM DISSOCIATED MOUSE BRAIN HEMISPHERES

1977 • 343 citations

The fine structural localization of glutamate decarboxylase in synaptic terminals of rodent cerebellum

1974 • 332 citations

Purification and Characterization of Glutamate Decarboxylase from Mouse Brain

1973 • 318 citations

Effect of frontal cortex ablation on striatal glutamic acid level in rat

1977 • 306 citations

The operation of the γ-aminobutyrate bypath of the tricarboxylic acid cycle in brain tissue in vitro

1970 • 306 citations

Localizing 3H-GABA in Nerve Terminals of Rat Cerebral Cortex by Electron Microscopic Autoradiography

1971 • 303 citations

Metabolic Compartmentation and Neurotransmission

1975 • 301 citations

Aspartate and glutamate as possible transmitters of excitatory hippocampal afferents

1976 • 300 citations

AMINO ACID AND PROTEIN METABOLISM‐VI CEREBRAL COMPARTMENTS OF GLUTAMIC ACID METABOLISM

1961 • 295 citations

Selective uptake of [3H]β-alanine by glia: Association with the glial uptake system for GABA

1975 • 288 citations

On the Role of Glial Cells in the Mammalian Nervous System

1974 • 277 citations

Müller cell localisation of glutamine synthetase in rat retina

1977 • 265 citations

AMINO ACIDS AS CENTRAL NERVOUS TRANSMITTERS: THE INFLUENCE OF IONS, AMINO ACID ANALOGUES, AND ONTOGENY ON TRANSPORT SYSTEMS for <scp>l</scp>‐GLUTAMIC AND <scp>l</scp>‐ASPARTIC ACIDS AND GLYCINE INTO CENTRAL NERVOUS SYNAPTOSOMES OF THE RAT¹

1973 • 261 citations

Locations of amino acids in brain slices from the rat. Tetrodotoxin-sensitive release of amino acids

1972 • 260 citations

GLYCINE UPTAKE IN RAT CENTRAL NERVOUS SYSTEM SLICES AND HOMOGENATES: EVIDENCE FOR DIFFERENT UPTAKE SYSTEMS IN SPINAL CORD AND CEREBRAL CORTEX

1971 • 256 citations

Uptake of the neurotransmitter candidate glutamate by glia

1974 • 247 citations

Functional interactions between neurons and astrocytes. II. Potassium homeostasis at the cellular level

1983 • 246 citations

Glutamic acid as a synaptic transmitter in the nervous system. A review

1972 • 243 citations

Electrochemical aspects of physiological and pharmacological action in excitable cells. II. The action potential and excitation.

1958 • 240 citations

Regional gamma-aminobutyric acid levels in rat brain determined after microwave fixation.

1975 • 235 citations

High Concentration of GABA and High Glutamate Decarboxylase Activity in Rat Pancreatic Islets and Human Insulinoma

1976 • 235 citations

EFFECTS OF SODIUM GLUTAMATE ON THE NERVOUS SYSTEM

1954 • 235 citations

Amino Acid Transmitters

1970 • 235 citations

Autoradiographic localisation of [3H]GABA and [3H]glutamate over satellite glial cells

1974 • 230 citations

The maintenance and identification of mouse cerebellar granule cells in monolayer culture

1977 • 230 citations

THE EFFECT OF ELECTRICAL STIMULATION AND HIGH POTASSIUM CONCENTRATIONS ON THE EFFLUX OF [³H] γ‐AMINOBUTYRIC ACID FROM BRAIN SLICES

1969 • 227 citations

Regulation of Acetylcholinesterase in Neuroblastoma Cells

1970 • 225 citations

Electrophysiology of Neuroglia

1975 • 225 citations

Investigation of glial cells in semithin sections. II. Variation with age in the numbers of the various glial cell types in rat cortex and corpus callosum

1973 • 224 citations

Dopamine selectively increases 3H-GABA release from slices of rat substantia nigra in vitro

1977 • 218 citations

Localization and Release of Glutamic Acid in Relation to the Hippocampal Mossy Fibre Pathway

1973 • 215 citations

Kinetic characteristics of the glutamate uptake into normal astrocytes in cultures

1978 • 213 citations

REGIONAL γ‐AMINOBUTYRIC ACID LEVELS IN RAT BRAIN DETERMINED AFTER MICROWAVE FIXATION

1975 • 210 citations

RELEASE OF γ‐AMINOBUTYRIC ACID INTO THE FOURTH VENTRICLE INDUCED BY STIMULATION OF THE CAT'S CEREBELLUM

1969 • 207 citations

On glutaminase activity in mammalian synaptosomes

1976 • 204 citations

The release of γ‐aminobutyric acid during inhibition in the cat visual cortex

1971 • 201 citations

RELEASE OF [³H]GAMMA-AMINOBUTYRIC ACID FROM GLIAL CELLS IN RAT DORSAL ROOT GANGLIA.

1974 • 194 citations

Rate of release of amino acids from the cerebral cortex in the cat as affected by brainstem and thalamic stimulation

1969 • 194 citations

Selective Destruction of Neurons by a Transmitter Agonist

1977 • 193 citations

Na+-K+-activated adenosinetriphosphatase as a trigger in transmitter release

1978 • 191 citations

MEASUREMENT OF γ‐AMINOBUTYRIC ACID IN ISOLATED NERVE CELLS OF CAT CENTRAL NERVOUS SYSTEM

1971 • 189 citations

Uptake and metabolism of GABA in astrocytes cultured from dissociated mouse brain hemispheres

1977 • 186 citations

METABOLISM OF AMINO ACIDS AND AMMONIA IN RAT BRAIN CORTEX SLICES IN VITRO: A POSSIBLE ROLE OF AMMONIA IN BRAIN FUNCTION

1975 • 185 citations

Stimulus‐secretion coupling processes in brain: analysis of noradrenaline and gamma‐aminobutyric acid release.

1976 • 183 citations

Studies on brain metabolism

1936 • 181 citations

RESPIRATION IN VITRO OF SYNAPTOSOMES FROM MAMMALIAN CEREBRAL CORTEX

1969 • 181 citations

POSTNATAL CHANGES IN FREE AMINO ACID POOL OF RAT BRAIN

1966 • 176 citations

GFA Content, Glutamate Uptake and Activity of Glutamate Metabolizing Enzymes in Differentiating Mouse Astrocytes in Primary Cultures

1978 • 173 citations

Glutamic Acid Decarboxylase

1960 • 172 citations

Golgi centennial symposium: Perspectives in neurobiology

1976 • 171 citations

Autoradiographic Localization of 3H-GABA in Rat Retina

1972 • 170 citations

Exchange of neurotransmitter amino acid at nerve endings can simulate high affinity uptake

1974 • 168 citations

Metabolic Compartments in the Brain: Their Properties and Relation to Morphological Structures

1973 • 166 citations

Amino Acids as Neurotransmitters

1978 • 164 citations

γ-Aminobutyric Acid Uptake by Sympathetic Ganglia

1972 • 162 citations

The autoradiographic localization of L-[3H]glutamate in rat brain tissue

1976 • 160 citations

Glutamine as precursor for the GABA and glutamate trasmitter pools

1978 • 158 citations

Amino Acid Transport

1972 • 157 citations

Potassium-induced release of amino acids from cerebral cortex and spinal cord slices of the rat

1974 • 156 citations

The distribution of free amino acids in subcellular fractions of guinea-pig brain

1966 • 155 citations

Potassium-stimulated γ-aminobutyric acid release from neurons and glia

1977 • 154 citations

DISSOCIATED BRAIN CELLS IN PRIMARY CULTURES

1977 • 152 citations

Thin-layer chromatography of 1-dimethylaminonaphthalene-5-sulphonyl derivatives of amino acids present in superfusates of cat cerebral cortex

1967 • 149 citations

DNA Metabolism and Cell Proliferation

1969 • 149 citations

AMINO ACID AND PROTEIN METABOLISM OF THE BRAIN—IV

1959 • 149 citations

THE EFFECT OF INTRAHIPPOCAMPAL KAINIC ACID INJECTIONS AND SURGICAL LESIONS ON NEUROTRANSMITTERS IN HIPPOCAMPUS AND SEPTUM

1978 • 147 citations

Glutamate release from the retina during spreading depression

1970 • 146 citations

Glial contamination of synaptosomal fractions

1976 • 146 citations

Cellular localization of labeled gamma-aminobutyric acid (3H_GABA) in rat cerebellar cortex: an autoradiographic study

1970 • 145 citations

Amino Acid Neurotransmitter Candidates: Sodium-Dependent High-Affinity Uptake by Unique Synaptosomal Fractions

1972 • 144 citations

The excitant amino acids glutamic and aspartic acid as transmitter candidates in the vertebrate central nervous system

1978 • 144 citations

NEUROGLIAL LOCALIZATION OF POTASSIUM AND SODIUM EFFECTS ON RESPIRATION IN BRAIN

1966 • 143 citations

The uptake of [3]Hγ-amino butyric acid and [3H]glycine by the isolated retina of the frog

1974 • 143 citations

EFFECTS OF ELEVATED [K⁺]₀ ON THE RELEASE OF NEUROTRANSMITTERS FROM CORTICAL SYNAPTOSOMES: EFFLUX OR SECRETION?

1978 • 143 citations

METABOLISM OF GLUCOSE AND GLUTAMATE BY SYNAPTOSOMES FROM MAMMALIAN CEREBRAL CORTEX

1969 • 142 citations

EFFECT OF IONS ON STIMULUS-INDUCED RELEASE OF AMINO ACIDS FROM MAMMALIAN BRAIN SLICES

1969 • 141 citations

DEPOLARIZING STIMULI AND THE RELEASE OF PHYSIOLOGICALLY ACTIVE AMINO ACIDS FROM SUSPENSIONS OF MAMMALIAN SYNAPTOSOMES

1973 • 141 citations

Purification and characterization of the 4-aminobutyrate-2-ketoglutarate transaminase from mouse brain

1973 • 141 citations

Independence of Protein Synthesis and Drug Uptake in Nerve Cell Bodies and Glial Cells isolated by a New Technique

1971 • 141 citations

The fine structural localization of glutamate decarboxylase in developing axonal processes and presynaptic terminals of rodent cerebellum

1975 • 139 citations

QUANTITATIVE ASPECTS OF CO₂ FIXATION IN MAMMALIAN BRAIN IN VIVO*

1964 • 139 citations

Changes in d(-)-β-Hydroxybutyric Dehydrogenase Activity during Brain Maturation in the Rat

1967 • 138 citations

PHOSPHATE ACTIVATED GLUTAMINASE ACTIVITY AND GLUTAMINE UPTAKE IN PRIMARY CULTURES OF ASTROCYTES

1979 • 138 citations

Detectability of high and low affinity uptake systems for GABA and glutamate in rat brain slices and synaptosomes

1973 • 135 citations

THE HETEROGENEITY OF RAT BRAIN MITOCHONDRIA ISOLATED ON CONTINUOUS SUCROSE GRADIENTS¹

1969 • 134 citations

MANIFESTATION OF METABOLIC COMPARTMENTATION DURING THE MATURATION OF THE RAT BRAIN

1970 • 134 citations

Two mechanisms for spreading depression in the chicken retina

1978 • 134 citations

KINETICS OF THE SODIUM‐DEPENDENT TRANSPORT OF GAMMA‐AMINOBUTYRIC ACID BY SYNAPTOSOMES

1973 • 133 citations

The inactivation of extracellularly administered amino acids in the feline spinal cord

1970 • 133 citations

Action and uptake of neurotransmitters in cns tissue culture

1978 • 133 citations

HIGH AFFINITY UPTAKE OF L‐GLUTAMATE AND L‐ASPARTATE BY GLIAL CELLS

1977 • 132 citations

Metabolic response of synaptosomes to electrical stimulation: Release of amino acids

1970 • 131 citations

IONS AND THE TRANSPORT OF GAMMA‐AMINOBUTYRIC ACID BY SYNAPTOSOMES

1972 • 131 citations

ORNITHINE AND GLUTAMIC ACID DECARBOXYLASE ACTIVITIES IN THE DEVELOPING CHICK RETINA

1976 • 126 citations

Subcellular fractionation of cultured glial cells

1971 • 125 citations

An estimation of the concentration of γ-aminobutyric acid and glutamate decar☐ylase in the inhibitory Purkinje axon terminals in the cat

1973 • 123 citations

INTRACELLULAR LOCALIZATION OF GLUTAMATE DECARBOXYLASE, γ‐AMINOBUTYRATE TRANSAMINASE AND SOME OTHER ENZYMES IN BRAIN TISSUE

1965 • 123 citations

The uptake of [3H]GABA and differentiation of stellate neurons in cultures of dissociated postnatal rat cerebellum

1974 • 123 citations

COUPLED TRANSPORT OF GLUTAMATE AND SODIUM IN A CEREBELLAR NERVE CELL LINE

1979 • 122 citations

Effects of Neurohormones on Glial Cells

1980 • 120 citations

BIOCHEMICAL CORRELATES OF TRANSMISSION MEDIATED BY GLUTAMATE AND ASPARTATE

1978 • 119 citations

GABA—Biochemistry and CNS Functions

1979 • 119 citations

RELEASE AND EXCHANGE STUDIES RELATING TO THE SYNAPTOSOMAL UPTAKE OF GABA

1975 • 119 citations

Biochemical studies of isolated glial (muller) cells from the turtle retina

1978 • 119 citations

The Nature of Spreading Depression in Neural Networks

1962 • 118 citations

Ion and Energy Metabolism of the Brain at the Cellular Level

1975 • 117 citations

A Unique Synaptosomal Fraction, Which Accumulates Glutamic and Aspartic Acids, in Brain Tissue

1971 • 117 citations

Selective accumulation of [3H]GABA by stellate cells in rat cerebellar cortexin vivo

1972 • 117 citations

The release of endogenous amino acids from the rat visual cortex.

1976 • 116 citations

Cellular location of the uptake of some amino acids into the rabbit retina

1972 • 116 citations

THE HISTOCHEMICAL DEMONSTRATION OF γ‐AMINOBUTYRIC ACID METABOLISM BY REDUCTION OF A TETRAZOLIUM SALT*

1965 • 116 citations

The release of amino acids with proposed neurotransmitter function from the cuneate and gracile nuclei of the rat in vivo

1974 • 115 citations

PATTERNS OF AMINO ACID RELEASE FROM NERVE-ENDINGS ISOLATED FROM SPINAL CORD AND MEDULLA

1973 • 114 citations

CNS at the Cellular Level: Identity of Transmitter Agents

1970 • 113 citations

CHANGES WITH AGE IN THE UTILIZATION OF GLUCOSE CARBON IN LIVER AND BRAIN

1966 • 112 citations

Specific release of endogenous glutamate from piriform cortex stimulated in vitro

1976 • 112 citations

ON THE SITE OF ORIGIN OF TRANSMITTER AMINO ACIDS RELEASED BY DEPOLARIZATION OF NERVE TERMINALS IN VITRO

1977 • 111 citations

Autoradiographic localization of sites of [3H]γ-aminobutyric acid accumulation in peripheral autonomic ganglia

1973 • 111 citations

Amino acid uptake in neuronal and glial cell fractions from rabbit cerebral cortex

1971 • 109 citations

Uptake of certain possible neurotransmitters into retinal neurons of some mammals

1974 • 109 citations

CHARACTERIZATION OF PUTATIVE AMINO ACID TRANSMITTER RELEASE FROM SLICES OF RAT DENTATE GYRUS

1977 • 107 citations

Neurochemical correlates of synaptically active amino acids

1974 • 107 citations

The free amino acids in human cerebrospinal fluid

1972 • 107 citations

SUBCELLULAR DISTRIBUTION OF ENZYMES OF GLUTAMATE METABOLISM IN RAT BRAIN

1966 • 106 citations

SOME OBSERVATIONS ON THE EFFECT OF <scp>d</scp>‐GLUTAMATE ON THE GLUCOSE METABOLISM AND THE ACCUMULATION OF POTASSIUM IONS IN BRAIN CORTEX SLICES

1959 • 106 citations

Efflux of amino acid neurotransmitters from rat spinal cord slices. II. Factors influencing the electrically induced efflux of [14Cglycine and3H-GABA

1971 • 105 citations

Regional distribution of postsynaptic receptor binding for gamma-aminobutyric acid (GABA) in monkey brain

1975 • 105 citations

Uptake of neurotransmitters by clonal lines of astrocytoma and neuroblastoma in culture. I. Transport of γ-aminobutyric acid

1974 • 104 citations

NEURONAL AND GLIAL SYSTEMS FOR γ‐AMINOBUTYRIC ACID METABOLISM

1975 • 104 citations

The clearing of excess potassium from extracellular space in spinal cord and cerebral cortex

1978 • 102 citations

THE SUBCELLULAR DISTRIBUTIONS OF ACETYLCHOLINE, SUBSTANCE P, 5‐HYDROXYTRYPTAMINE, γ‐AMINOBUTYRIC ACID AND GLUTAMIC ACID IN BRAIN HOMOGENATES

1964 • 102 citations

POTASSIUM OUTFLUX FROM RABBIT CORTEX DURING SPREADING DEPRESSION

1960 • 101 citations

A Model of Glutamate Metabolism in Brain: A Biochemical Analysis of a Heterogeneous Structure

1975 • 100 citations

Influence of membrane potential on the sodium-dependent uptake of gamma-aminobutyric acid by presynaptic nerve terminals: Experimental observations and theoretical considerations

1976 • 98 citations

NEURONAL CELL BODY ENRICHED AND GLIAL CELL ENRICHED FRACTIONS FROM YOUNG AND ADULT RAT BRAINS: PREPARATION AND MORPHOLOGICAL AND BIOCHEMICAL PROPERTIES

1974 • 98 citations

Effects of selective doses of x-irradiation on the levels of several amino acids in the cerebellum of the rat

1976 • 97 citations

A Model of Compartmentation in Mouse Brain Based on Glucose and Acetate Metabolism

1973 • 97 citations

ENZYMES OF ENERGY-CONVERTING SYSTEMS IN INDIVIDUAL MAMMALIAN NERVE CELL BODIES

1973 • 96 citations

ADRENERGIC α‐ AND β‐RECEPTORS EXPRESSED BY THE SAME CELL TYPE IN PRIMARY CULTURE OF PERINATAL MOUSE BRAIN

1978 • 96 citations

CEREBRAL UPTAKES AND EXCHANGE DIFFUSION IN VITRO OF <scp>l</scp>‐ AND <scp>d</scp>‐GLUTAMATES

1976 • 96 citations

The uptake ofl-glutamate by the retina

1976 • 95 citations

Transport Phenomena in the Nervous System

1976 • 95 citations

PUTATIVE TRANSMITTERS IN DENERVATED OLFACTORY CORTEX

1975 • 95 citations

NEURONAL AND GLIAL SYSTEMS FOR γ‐AMINOBUTYRIC ACID TRANSPORT

1975 • 94 citations

SUBSTANCES WHICH SUPPORT RESPIRATION AND METABOLIC RESPONSE TO ELECTRICAL IMPULSES IN HUMAN CEREBRAL TISSUES

1953 • 92 citations

CALCIUM‐DEPENDENT RELEASE OF EXOGENOUSLY LOADED γ‐AMINO‐[U‐¹⁴C]BUTYRATE FROM SYNAPTOSOMES: TIME COURSE OF STIMULATION BY POTASSIUM, VERATRIDINE, AND THE CALCIUM IONOPHORE, A23187

1976 • 90 citations

High affinity uptake of GABA in presumed GABA-ergic nerve endings in rat brain

1975 • 89 citations

Patterns of Excitation of Thalamic Neurones by Amino-acids and by Acetylcholine

1968 • 88 citations

GLIAL CELL LINES

1977 • 88 citations

Application of cytochemical techniques to the study of suspected transmitter substances in the nervous system.

1972 • 88 citations

An investigation of the cells incorporating [3H]GABA and [3H]glycine in the isolated retina of the rat

1974 • 88 citations

The metabolism of γ-aminobutyrate and glucose in potassium ion-stimulated brain tissue in vitro

1970 • 86 citations

Carbohydrate – Amino-Acid Inter-Relations in Brain Cortex In Vitro

1959 • 85 citations

METABOLIC COMPARTMENTATION OF GLUTAMATE ASSOCIATED WITH THE FORMATION OF γ‐AMINOBUTYRATE

1974 • 83 citations

Possible relationship between glial cells, dopamine and the effects of antipsychotic drugs

1977 • 82 citations

Univalent cations and the respiration of brain-cortex slices

1962 • 82 citations

Evaluation of glutamate as a hippocampal neurotransmitter: Glutamate uptake and release from synaptosomes

1978 • 81 citations

Kinetic analysis of amino acid uptake by the rat retina in vitro.

1973 • 80 citations

COMPARTMENTATION OF CITRIC ACID CYCLE METABOLISM IN BRAIN: LABELLING OF GLUTAMATE, GLUTAMINE, ASPARTATE AND GABA BY SEVERAL RADIOACTIVE TRACER METABOLITES¹

1970 • 80 citations

Evidence for net uptake of GABA into mouse astrocytes in primary cultures?Its sodium dependence and potassium independence

1978 • 80 citations

GLUTAMINE UPTAKE AND METABOLISM BY THE ISOLATED TOAD BRAIN: EVIDENCE PERTAINING TO ITS PROPOSED ROLE AS A TRANSMITTER PRECURSOR

1977 • 78 citations

FACTORS INFLUENCING THE EFFLUX OF [³H]GAMMAAMINOBUTYRIC ACID FROM SATELLITE GLIAL CELLS IN RAT SENSORY GANGLIA

1975 • 78 citations

REGIONAL CHANGES IN AMINO ACID CONTENT IN DEVELOPING RAT BRAIN¹

1974 • 78 citations

Subcellular distribution of glutamic decarboxylase and gamma- aminobutyric alpha-ketoglutaric transaminase

1963 • 78 citations

Glutamine and glutamate as precursors of the releasable pool of gaba in brain cortex slices

1978 • 77 citations

L‐GLUTAMIC ACID DECARBOXYLASE IN NON‐NEURAL TISSUES OF THE MOUSE

1974 • 75 citations

Glutamate accumulation by a clone of glial cells

1974 • 75 citations

CHARACTERISTICS OF GLUTAMINE vs GLUTAMATE TRANSPORT IN ISOLATED GLIA AND SYNAPTOSOMES

1979 • 74 citations

RELATIONSHIP BETWEEN Ca²⁺‐DEPENDENT AND INDEPENDENT RELEASE OF [³H]GABA EVOKED BY HIGH K⁺, VERATRIDINE OR ELECTRICAL STIMULATION FROM RAT CORTICAL SLICES

1979 • 74 citations

[¹⁴C]GLUTAMATE UPTAKE AND COMPARTMENTATION IN GLIA OF RAT DORSAL SENSORY GANGLION

1974 • 73 citations

GLUCOSE AND AMINO ACID METABOLISM IN ISOLATED NEURONAL AND GLIAL CELL FRACTIONS IN VITRO

1968 • 73 citations

Neurotransmission and glial cells: A functional relationship?

1976 • 73 citations

A Sensitive Double Isotope Derivative Assay to measure Release of Amino Acids from Brain in vitro

1973 • 73 citations

THE METABOLISM OF GAMMA AMINOBUTYRIC ACID IN THE LOBSTER NERVOUS SYSTEM

1970 • 72 citations

High content of glutamate and of ATP in Astrocytes cultured from rat brain hemispheres: effect of serum withdrawal and of cyclic AMP

1975 • 72 citations

LOCALIZATION OF γ‐AMINOBUTYRIC‐α‐OXOGLUTARIC ACID TRANSAMINASE IN MOUSE BRAIN*

1968 • 72 citations

Glutamate and Glutamine

1970 • 71 citations

Tetanus Toxin inhibits Amino Acid Release from Nerve Endings in vitro

1973 • 71 citations

Stimulus evoked increase in the biosynthesis of the putative neurotransmitters glutamate in the hippocampus

1978 • 71 citations

Amino acid release from isolated rat dorsal root ganglia

1974 • 70 citations

Involvement of glutamate in memory formation

1974 • 70 citations

γ-Aminobutyric Acid in the Rat Peripheral Nervous System, Pineal and Posterior Pituitary

1974 • 70 citations

K + induced stimulation of oxygen uptake in cultured cerebral glial cells

1973 • 70 citations

EFFECTS OF POTASSIUM AND GLUTAMATE ON BRAIN CORTEX SLICES: UPTAKE AND RELEASE OF GLUTAMIC AND OTHER AMINO ACIDS

1971 • 69 citations

Difference between isolated neuronal and vascular glia with respect to respiratory activity.

1963 • 69 citations

Effects of some inorganic salts on the metabolic response of sections of mammalian cerebral cortex to electrical stimulation

1952 • 69 citations

KINETICS OF ADENOSINE UPTAKE INTO ASTROCYTES

1978 • 68 citations

EFFECT OF STIMULATION OF EXCITATORY NERVE TRACT ON RELEASE OF GLUTAMIC ACID FROM OLFACTORY CORTEX SLICES IN VITRO

1976 • 67 citations

Histogenesis of the anterior limb of the anterior commissure of the mouse brain. 3. An electron microscopic study of gliogenesis.

1974 • 67 citations

Serotonin receptors on astrocytes in primary cultures: Effects of methysergide and fluoxetine

1979 • 67 citations

HIGH AFFINITY UPTAKE OF <scp>l</scp>‐GLUTAMINE IN RAT BRAIN SLICES

1975 • 66 citations

Inhibition of the high-affinity, net uptake of GABA into cultured astrocytes by β-proline, nipecotic acid and other compounds

1978 • 66 citations

BIOCHEMISTRY OF GLIAL CELLS

1977 • 66 citations

Mechanisms involved in spreading depression

1973 • 65 citations

Differentiation of bergmann glia cells in the cerebellum: a golgi study

1976 • 65 citations

The efflux of45Ca2+ and [3H]γ-aminobutyric acid from cat cerebral cortex

1973 • 64 citations

γ-Aminobutyric acid, bicuculline, and post-synaptic binding sites

1973 • 64 citations

The γ-aminobutyric acid system in the developing chick embryo cerebellum

1968 • 63 citations

An artifact in the radiochemical assay of brain mitochondrial glutamate decarboxylase

1973 • 61 citations

Effect of inhibitors of γ‐aminobutyrate aminotransferase on the accumulation of H‐γ‐aminobutyric acid by the retina

1973 • 60 citations

Uptake and release of γ-aminobutyric acid (GABA) in slices of substantia nigra of rat

1973 • 60 citations

METABOLISM OF POLYAMINES IN MOUSE NEUROBLASTOMA CELLS IN CULTURE:¹ FORMATION OF GABA AND PUTREANINE

1975 • 60 citations

Responses of cultured cerebellar neurons to iontophoretically applied amino acids

1974 • 57 citations

A COMPARISON OF GABA AND β‐ALANINE TRANSPORT AND GABA MEMBRANE BINDING IN THE RAT BRAIN¹

1978 • 56 citations

STUDIES ON THE METABOLISM OF BRAIN SUSPENSIONS

1942 • 56 citations

Incorporation of label from <scp>d</scp>-β-hydroxy-[14C]butyrate and [3-14C]acetoacetate into amino acids in rat brain in vivo

1971 • 56 citations

Spinal cord tissue cultures-a model for autoradiographic studies on uptake of putative neurotransmitters such as glycine and GABA

1972 • 56 citations

AMINO ACID RELEASE FROM THE CEREBRAL CORTEX DURING SPREADING DEPRESSION AND ASPHYXIATION*

1965 • 55 citations

Influence of potassium ions on accumulation and metabolism of [14C]glucose by glial cells

1975 • 55 citations

Regional differences in the synaptosomal uptake of 3H-gamma-aminobutyric acid and 14C-glutamate and possible role of exchange processes.

1974 • 55 citations

POTASSIUM EFFECTS ON ION TRANSPORT IN BRAIN SLICES

1968 • 55 citations

Glutamate decarboxylase activity in the rat posterior pituitary, pineal gland, dorsal root ganglion and superior cervical ganglion

1976 • 54 citations

PROPERTIES OF <scp>l</scp>‐GLUTAMATE DECARBOXYLASE FROM BRAINS OF ADULT AND NEWBORN MICE¹

1976 • 54 citations

EFFECTS OF GLUTAMATE AND OTHER AMINO ACIDS ON THE RETINA¹

1971 • 53 citations

AMINO ACID METABOLISM IN GLIAL CELLS: HOMEOSTATIC REGULATION OF INTRA‐ and EXTRACELLULAR MILIEU BY C‐6 GLIOMA CELLS

1978 • 52 citations

Release of γ-aminobutyric acid from hippocampal slices of the rat following generalized seizures induced by daily electrical stimulation of entorhinal cortex

1977 • 52 citations

Polarographic measurement of oxygen uptake by astrocytes in primary cultures using the tissue-culture flask as the respirometer chamber

1979 • 52 citations

Verification and quantification of GABA in human cerebrospinal fluid

1978 • 52 citations

The uptake of [14C]γ-aminobutyric acid by the isolated retina of the rat

1972 • 51 citations

Distribution and localization of sites of gamma aminobutyric acid metabolism in the adult rat brain.

1973 • 51 citations

Transport and metabolism of acetate in rat brain cortex in vitro

1966 • 50 citations

EFFECTS OF POTASSIUM AND SODIUM ON RESPIRATION: THEIR SPECIFICITY TO SLICES FROM CERTAIN BRAIN REGIONS

1963 • 50 citations

The synaptosome: An isolated, working, neuronal compartment

1973 • 50 citations

Uptake of GABA by neuronal and nonneuronal cells in dispersed cell cultures of postnatal rat cerebellum

1975 • 49 citations

How selective is high affinity uptake of GABA into inhibitory nerve terminals?

1974 • 49 citations

Effect of amino-oxyacetic acid on the accumulation of 3H- -aminobutyric acid (3H-GABA) by rat retina.

1973 • 49 citations

Glycine: Its Metabolic and Possible Transmitter Roles in Nervous Tissue

1970 • 49 citations

The concentration of GABA within inhibitory nerve terminals

1973 • 48 citations

NET UPTAKE OF L‐GLUTAMATE AND GABA BY HIGH AFFINITY SYNAPTOSOMAL TRANSPORT SYSTEMS

1978 • 48 citations

THE COMPARTMENTATION OF GLUTAMATE AND ITS METABOLITES IN FRACTIONS OF NEURON CELL BODIES AND NEUROPIL; STUDIED BY INTRAVENTRICULAR INJECTION OF [U‐¹⁴C]GLUTAMATE

1970 • 47 citations

NET PRODUCTION OF γ‐AMINOBUTYRIC ACID IN ASTROCYTES IN PRIMARY CULTURES DETERMINED BY A SENSITIVE MASS SPECTROMETRIC METHOD

1979 • 47 citations

Net uptake of gamma-aminobutyric acid by a high affinity synaptosomal transport system.

1977 • 47 citations

Scanning and transmission electron microscopy on bulk prepared neuronal and glial cells

1975 • 46 citations

Effect of K⁺‐stimulation on GABA metabolism in brain slices in vitro

1967 • 46 citations

A MODEL OF HIGH AFFINITY GLUTAMIC ACID TRANSPORT BY CORTICAL SYNAPTOSOMES FROM THE LONG‐EVANS RAT

1978 • 46 citations

UPTAKE AND RELEASE OF POSSIBLE FALSE TRANSMITTER AMINO ACIDS BY RAT BRAIN TISSUE¹

1974 • 45 citations

Polyfunctional role of glutamic acid in excitatory synaptic transmission

1976 • 45 citations

The autoradiographic localization of L-[3H] glutamate in synaptosomal preparations

1976 • 45 citations

Utilization in vivo of glucose and volatile fatty acids by sheep brain for the synthesis of acidic amino acids

1966 • 44 citations

Functional assessment of GABA uptake or exchange by synaptosomal fractions

1976 • 43 citations

The uptake of gaba by clonal nerve and glia

1975 • 42 citations

Metabolic action of the cardiac glycosides; influence on respiration of heart muscle and brain cortex.

1947 • 42 citations

Amino acids in the synaptic vesicle fraction from calf brain: content, uptake and metabolism

1977 • 42 citations

DNA Metabolism and Cell Proliferation

1969 • 41 citations

RESPIRATION BY CULTIVATED ASTROCYTES AND NEURONS FROM THE CEREBRAL HEMISPHERES

1973 • 41 citations

FLUOROACETATE AND THE METABOLISM OF AMMONIA IN BRAIN

1963 • 41 citations

POSTNATAL ALTERATIONS IN EFFECTS OF POTASSIUM ON UPTAKE AND RELEASE OF GLUTAMATE AND GABA IN RAT BRAIN CORTEX SLICES

1976 • 41 citations

Glutamate and GABA uptake by cerebellar granule and glial cell enriched populations

1978 • 40 citations

Effect of elevated extracellular potassium on the release of labelled noradrenaline, glutamate, glycine, β-alanine and other amino acids from rat brain cortex slices

1977 • 40 citations

QUANTITATIVE DETERMINATION OF DNA IN PRESERVED BRAINS AND BRAIN SECTIONS¹

1972 • 40 citations

High-affinity uptake system for glutamine in rat dorsal roots but not in nerve-endings

1974 • 40 citations

Transport phenomena in the nervous system — Physiological and pathological aspects

1977 • 40 citations

Autoradiographic localization of 3H-gamma-aminobutyric acid in the medial hypothalamus

1975 • 38 citations

HISTOCHEMICAL LOCALIZATION OF BRAIN SUCCINIC SEMIALDEHYDE DEHYDROGENASE-A γ-AMINOBUTYRIC ACID DEGRADATIVE ENZYME

1971 • 37 citations

Glutamic acid as a synaptic transmitter candidate in the dorsal sensory neuron: Reconsiderations

1977 • 37 citations

Chemical and autoradiographic analysis of γ-aminobutyric acid transport in Purkinje cells of the cerebellum

1975 • 37 citations

The Localization and Metabolism of Neuroactive Amino Acids in the Retina

1978 • 35 citations

The Neurochemistry of Nucleotides and Amino Acids

1961 • 35 citations

Electrically induced, calcium-dependent release of endogenous GABA from rat brain cortex slices

1978 • 35 citations

Amino acid uptake into human brain tumors

1974 • 34 citations

Studies on the control of 4-aminobutyrate metabolism in ‘synaptosomal’ and free rat brain mitochondria

1976 • 33 citations

The derivation and characterization of neuronal cell lines from rat and mouse brain

1977 • 33 citations

Electron microscopic autoradiography of the uptake of [3H]GABA in dispersed cell cultures of rat cerebellums. I. The morphology of the gabaergic synapse

1978 • 32 citations

L-proline and related compounds: Correlation of structure, amnesic potency and anti-spreading depression potency

1978 • 31 citations

Effect of Norepinephrine on Glucose Metabolism in Glioblastoma and Neuroblastoma Cells in Cell Culture

1972 • 31 citations

DIFFERENCES BETWEEN ASTROCYTES IN PRIMARY CULTURES AND GLIAL CELL LINES IN UPTAKE AND METABOLISM OF PUTATIVE AMINO ACID TRANSMITTERS

1977 • 30 citations

Some Age‐Dependent Biochemical Changes in Mice Susceptible to Seizures

1974 • 30 citations

Biochemical and morphological studies of the short and long term survival of isolated nerve-endings

1975 • 30 citations

A COMPARATIVE STUDY OF L‐GLUTAMATE DECARBOXYLASE FROM MOUSE BRAIN AND BOVINE HEART WITH PURIFIED PREPARATIONS¹

1977 • 30 citations

RELEASE OF [³H]GABA FROM IN VITRO PREPARATIONS: COMPARISON OF THE EFFECT OF DABA AND β‐ALANINE ON THE K⁺ AND PROTOVERATRINE STIMULATED RELEASE OF [³H]GABA FROM BRAIN SLICES AND SYNAPTOSOMES¹

1979 • 29 citations

The Localization of Glutamate Decarboxylase, Choline Acetyltransferase, and Aromatic Amino Acid Decarboxylase in Mammalian and Invertebrate Nervous Tissue

1975 • 28 citations

Effects of Veratrine and Cocaine on Cerebral Carbohydrate-Amino Acid Interrelations

1960 • 27 citations

Compartmentation and the Metabolism of γ-Aminobutyrate

1973 • 27 citations

Effects of LI+ on the metabolism in brain of glutamate, glutamine, aspartate and gaba from [1-14C]acetate in vitro

1972 • 26 citations

INTRACELLULAR AMINO ACID CONTENT OF NEURONAL, GLIAL, AND NON-NEURAL CELL CULTURES: THE RELATIONSHIP TO GLUTAMIC ACID COMPARTMENTATION

1977 • 26 citations

THE INFLUENCE OF SODIUM, POTASSIUM AND LANTHANUM ON AMINO ACID RELEASE FROM SPINAL–MEDULLARY SYNAPTOSOMES

1975 • 26 citations

Uptake and Exchange of GABA and Glutamate in Isolated Nerve Endings

1976 • 26 citations

Amino Acid Transport in Spinal and Sympathetic Ganglia

1976 • 25 citations

Energy metabolism of nerve cells during differentiation

1973 • 25 citations

Uptake of GABA in dispersed cell cultures of postnatal rat cerebellum: an electron microscope autoradiographic study

1975 • 25 citations

Studies on the GABAergic system in astrocytoma and neuroblastoma cells in culture

1977 • 25 citations

Sedimentation characteristics of subcellular vesicles derived from three glial systems

1978 • 24 citations

Electron microscopic autoradiography of the uptake of [3H]GABA in dispersed cell cultures of rat cerebellums. II. The development of gabaergic synapses

1978 • 24 citations

An Experimental Model of CNS Changes Associated with Chronic Liver Disease: Portocaval Anastomosis in the Rat

1975 • 24 citations

STUDIES ON THE TRANSPORT OF GLUTAMINE IN VIVO BETWEEN THE BRAIN AND BLOOD IN THE RESTING STATE AND DURING AFFERENT ELECTRICAL STIMULATION

1978 • 22 citations

Net uptake of aspartate by a high-affinity rat cortical synaptosomal transport system

1979 • 22 citations

Factors Affecting the Development of Metabolic Compartmentation in the Brain

1975 • 22 citations

Electron cytochemical localization of gamma-aminobutyric acid catabolism in rat cerebellar cortex

1976 • 21 citations

Gamma aminobutyric acid and 5-hydroxytryptamine concentration in neurons and glial cells in the medical geniculate body of the cat

1963 • 21 citations

γ‐Aminobutyric Acid Release from Neurons and Glia

1976 • 21 citations

Improved histological localization of GABA-transaminase activity in rat cerebellar cortex after aldehyde fixation

1976 • 21 citations

Possible Correlations between Morphological Structures in the Brain and the Compartmentations Indicated by Simulation

1973 • 20 citations

Function of Glutathione in Kidney Via The γ-Glutamyl Cycle

1975 • 20 citations

Gamma-aminobutyric acid homoexchange in sensory ganglia

1976 • 19 citations

Effects of acetylcholine on potassium-induced changes of GABA and taurine uptakes and release in cerebral cortex slices from the rat

1977 • 19 citations

THE UTILIZATION OF GLUTAMINE BY THE RETINA: AN AUTORADIOGRAPHIC AND METABOLIC STUDY

1978 • 18 citations

APPEARANCE OF GAMMA AMINOBUTYRATE TRANSAMINASE ACTIVITY IN DEVELOPING RAT BRAIN

1974 • 18 citations

Uptake of [14C]glutamate into dorsal and ventral roots of spinal nerves of the rat

1973 • 18 citations

Characterization of Neuronal and Glial Fractions Separated in Sucrose and Ficoll Media

1971 • 17 citations

Inhibition of γ-aminobutyric acid uptake into astrocytes by pentobarbital

1978 • 16 citations

Compartmentation of Tricarboxylic Acid Cycle Intermediates and Related Metabolites

1973 • 15 citations

A RADIOIMMUNOASSAY FOR MEASURING 14-3-2 PROTEIN IN CELL EXTRACTS

1976 • 15 citations

Glutamate accumulation by human gliomas and meningiomas in tissue culture

1976 • 15 citations

A comparison of γ‐aminobutyric acid metabolism in neurones versus glial cells using intact isolated retinae

1977 • 15 citations

RELEASE OF RADIOACTIVE GLUTAMIC ACID FROM THIN SECTIONS OF GUINEA‐PIG OLFACTORY CORTEX IN VITRO

1975 • 15 citations

NEURONAL CELL LINES

1977 • 15 citations

RELATIONSHIP BETWEEN SYNAPTOSOMAL UPTAKE AND RELEASE OF [¹⁴C]GABA, [¹⁴C]DIAMINOBUTYRIC ACID AND [¹⁴C]β‐ALANINE¹

1978 • 14 citations

The effect of pentobarbital on the carbohydrate metabolism of glial cells in culture

1977 • 14 citations

GANGLIOSIDES OF THE BOVINE NEUROHYPOPHYSIS

1975 • 14 citations

THE CEREBELLAR GLOMERULUS: ISOLATION AND METABOLIC PROPERTIES OF A PURIFIED FRACTION

1976 • 14 citations

The effects of increased potassium concentration on the metabolism of rat cerebral cortical slices.

1950 • 14 citations

An analysis of the compartmentation and proximo-distal convection of the glutamate-glutamine system in the dorsal sensory neuron: Comparison with the motoneuron and cerebral cortex

1974 • 14 citations

Effects of acetylcholine on potassium-induced changes of some amino acid uptakes and release in cerebral cortex slices from the rat

1977 • 13 citations

Computer simulation of the metabolism of guinea pig brain slices, and how they differ from the intact brain

1975 • 13 citations

EFFECTS OF ACETYLSALICYLATE AND 2,4-DINITROPHENOL ON METABOLISM AND TRANSPORT IN RAT BRAIN CORTEX IN VITRO

1963 • 12 citations

Effects of Different Potassium Ion Concentrations and of Procaine and Pentobarbital on [14C]Glutamate Fluxes in Rat Brain-Cortex Slices

1974 • 12 citations

Glutamic Acid, a Putative Neurotransmitter of Cerebellar Granule Cells: Evidence from the Virally Induced Granuloprival Cerebellum

1975 • 12 citations

Glutamic acid and primary afferent transmission.

1972 • 12 citations

Exchange versus net uptake of exogenously‐applied γ‐aminobutyric acid in retina

1976 • 12 citations

Efflux characteristics of isotopically labelled gamma-aminobutyric acid (GABA) and L-glutamate in the rat cuneate nucleus [proceedings].

1977 • 11 citations

Differential effect of veratridine and potassium depolarization on [3H]GABA release from neurones and glia [proceedings].

1978 • 11 citations

ACTIONS OF <scp>l</scp>‐GLUTAMATE AND RELATED AMINO ACIDS ON OXYGEN UPTAKE, LACTATE PRODUCTION AND NADH LEVELS OF RAT BRAIN IN VITRO

1977 • 11 citations

Comparative electron cytochemical studies of presynaptic and other neuronal mitochondria

1973 • 10 citations

Ethanol and Its Relation to Amino Acid Metabolism in Brain

1975 • 10 citations

Potassium Effects on Transport of Amino Acids, Inorganic Ions, and Water: Ontogenetic and Quantitative Differences

1976 • 10 citations

Distribution of H3-glycine and H3-l-glutamate in synaptosomal subpopulations after in vitro uptake into cat dorsal and ventral spinal cord slices

1974 • 9 citations

Glutamate secretion and NAD(P)H levels during calcium-dependent depolarization of slices of the dentate gyrus

1978 • 9 citations

Growth curve and rate of oxygen consumption by human glioma cells in culture

1974 • 9 citations

Ca²⁺-dependence of the evoked release from guinea pig cerebral cortex slices of endogenous ¹⁴C-labelled amino acids, labelled via <scp>D</scp>-[U-¹⁴C]glucose

1976 • 8 citations

Metabolic action of the cardiac glycosides, I. Influence on respiration of heart muscle and brain cortex

1948 • 7 citations

Biochemical Mapping of Specific Neuronal Pathways

1980 • 7 citations

Responses of synaptosomes to electrical stimulation

1970 • 7 citations

Metabolite Transport at Cell Membranes

1976 • 7 citations

Effect of chronic pentobarbital treatment on high affinity uptake of L-glutamate by cultured glial cells

1978 • 5 citations

Further Support for the Subdivision of the Small Metabolic Compartment: Effect of Halothane

1975 • 5 citations

Alteration in the Expression of Compartmentation: in vitro Studies

1973 • 5 citations

Effects of high serum levels, dibutyryl cyclic amp and hydrocortisone on glutamine synthetase activity in primary mouse astroglial cultures. Abstr.

1979 • 3 citations

Deleted Work

1955 • 0 citations