Target-Derived GFRα1 as an Attractive Guidance Signal for Developing Sensory and Sympathetic Axons via Activation of Cdk5

The GDNF family: Signalling, biological functions and therapeutic value

2002 • 1,722 citations

GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle

1994 • 1,261 citations

Renal and neuronal abnormalities in mice lacking GDNF

1996 • 1,260 citations

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1996 • 1,208 citations

GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

1996 • 1,170 citations

Defects in enteric innervation and kidney development in mice lacking GDNF

1996 • 1,169 citations

Characterization of a multicomponent receptor for GDNF

1996 • 1,086 citations

A decade of CDK5

2001 • 1,027 citations

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1994 • 915 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

GDNF signalling through the Ret receptor tyrosine kinase

1996 • 809 citations

Functional receptor for GDNF encoded by the c-ret proto-oncogene

1996 • 795 citations

Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF

1995 • 686 citations

Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons.

1995 • 595 citations

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

1996 • 592 citations

GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney

1998 • 550 citations

Neurotrophins are required for nerve growth during development

2001 • 519 citations

Complementary and Overlapping Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF), c-ret Proto-Oncogene, and GDNF Receptor-α Indicates Multiple Mechanisms of Trophic Actions in the Adult Rat CNS

1997 • 494 citations

GFRα1-Deficient Mice Have Deficits in the Enteric Nervous System and Kidneys

1998 • 463 citations

GDNF is an age-specific survival factor for sensory and autonomic neurons

1995 • 401 citations

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

1997 • 397 citations

GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo

1995 • 367 citations

Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor.

1995 • 337 citations

Ret-dependent and -independent Mechanisms of Glial Cell Line-derived Neurotrophic Factor Signaling in Neuronal Cells

1999 • 322 citations

ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1

2001 • 316 citations

GDNF Is a Chemoattractant for Enteric Neural Cells

2001 • 307 citations

GFRα-Mediated Localization of RET to Lipid Rafts Is Required for Effective Downstream Signaling, Differentiation, and Neuronal Survival

2000 • 307 citations

Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins

1997 • 302 citations

Released GFRα1 Potentiates Downstream Signaling, Neuronal Survival, and Differentiation via a Novel Mechanism of Recruitment of c-Ret to Lipid Rafts

2001 • 289 citations

RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons

2001 • 286 citations

Differential Regulation of mRNAs for GDNF and its Receptors Ret and GDNFRα After Sciatic Nerve Lesion in the Mouse

1997 • 242 citations

Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system

1996 • 236 citations

Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system

2000 • 215 citations

Expression of GDNF Family Receptor Components during Development: Implications in the Mechanisms of Interaction

1998 • 190 citations

Multiple GPI-Anchored Receptors Control GDNF-Dependent and Independent Activation of the c-Ret Receptor Tyrosine Kinase

1998 • 188 citations

Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons

1994 • 171 citations

Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells.

1995 • 161 citations

Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor Are Required Simultaneously for Survival of Dopaminergic Primary Sensory NeuronsIn Vivo

2001 • 157 citations

Developmental regulation of GDNF response and receptor expression in the enteric nervous system

2000 • 97 citations

The cyclin-dependent kinase Cdk5 controls multiple aspects of axon patterning in vivo

2000 • 84 citations

A rapid and dynamic regulation of GDNF-family ligands and receptors correlate with the developmental dependency of cutaneous sensory innervation

1999 • 71 citations

Chemosuppression of Retinal Axon Growth by the Mouse Optic Chiasm

1996 • 69 citations

GDNF and neurturin are target-derived factors essential for cranial parasympathetic neuron development

2001 • 69 citations

Nerve growth factors

1989 • 63 citations

Cultured basal forebrain cholinergic neurons in contact with cortical cells display synapses, enhanced morphological features, and decreased dependence on nerve growth factor

1996 • 35 citations

Cell-Cell Interactions

1992 • 7 citations