Multiple GPI-Anchored Receptors Control GDNF-Dependent and Independent Activation of the c-Ret Receptor Tyrosine Kinase

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

1993 • 1,941 citations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle

1994 • 1,261 citations

GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

1996 • 1,170 citations

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

1994 • 1,140 citations

Characterization of a multicomponent receptor for GDNF

1996 • 1,086 citations

Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

1995 • 1,084 citations

GDNF signalling through the Ret receptor tyrosine kinase

1996 • 809 citations

Functional receptor for GDNF encoded by the c-ret proto-oncogene

1996 • 795 citations

Mutations of the RET proto-oncogene in Hirschsprung's disease

1994 • 751 citations

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

1996 • 711 citations

Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

1994 • 702 citations

Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF

1995 • 686 citations

Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons.

1995 • 595 citations

In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons

1995 • 593 citations

Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin

1998 • 499 citations

Complementary and Overlapping Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF), c-ret Proto-Oncogene, and GDNF Receptor-α Indicates Multiple Mechanisms of Trophic Actions in the Adult Rat CNS

1997 • 494 citations

Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.

1988 • 434 citations

GDNF is an age-specific survival factor for sensory and autonomic neurons

1995 • 401 citations

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

1997 • 397 citations

GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo

1995 • 367 citations

TrnR2, a Novel Receptor That Mediates Neurturin and GDNF Signaling through Ret

1997 • 357 citations

ret transforming gene encodes a fusion protein homologous to tyrosine kinases.

1987 • 346 citations

Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins

1997 • 302 citations

Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase

1997 • 300 citations

Neurturin and Glial Cell Line-Derived Neurotrophic Factor Receptor-β (GDNFR-β), Novel Proteins Related to GDNF and GDNFR-α with Specific Cellular Patterns of Expression Suggesting Roles in the Developing and Adult Nervous System and in Peripheral Organs

1997 • 256 citations

Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis.

1996 • 237 citations

Postmigratory neural crest cells expressing c-RET display restricted developmental and proliferative capacities

1995 • 169 citations

Glial Cell Line-derived Neurotrophic Factor Signals through the RET Receptor and Activates Mitogen-activated Protein Kinase

1996 • 168 citations

Glial cell line-derived neurotrophic factor sustains axotomized basal forebrain cholinergic neurons in vivo: dose-response comparison to nerve growth factor and brain-derived neurotrophic factor.

1996 • 103 citations

Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha

1997 • 94 citations

GDNF Induces a Dystonia-like State in Neonatal Rats and Stimulates Dopamine and Serotonin Synthesis

1996 • 82 citations