Osmotic Induction of Signaling Cascades: Role in Regulation of Cell Function

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Functional Significance of Cell Volume Regulatory Mechanisms

1998 • 1,871 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

1994 • 1,091 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

The PHD finger: Implications for chromatin-mediated transcriptional regulation

1995 • 857 citations

Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27

1997 • 704 citations

Activation of Yeast PBS2 MAPKK by MAPKKKs or by Binding of an SH3-Containing Osmosensor

1995 • 649 citations

The role of cellular hydration in the regulation of cell function

1996 • 571 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

Regulation of Cell Volume in Health and Disease

1995 • 450 citations

Cellular hydration state: an important determinant of protein catabolism in health and disease

1993 • 434 citations

In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

1991 • 422 citations

Signal transduction in yeast

1994 • 385 citations

Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume

1997 • 372 citations

REGULATION OF GENE EXPRESSION BY HYPERTONICITY

1997 • 364 citations

Stress-activated Protein Kinases: Activation, Regulation and Function

1997 • 327 citations

Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27

1995 • 264 citations

Mechanosensitive Channels

1995 • 237 citations

Review of Mechanosensitive Channels

1995 • 228 citations

Autophagic proteolysis: control and specificity.

1997 • 228 citations

Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes

1996 • 227 citations

Cellular Stresses Differentially Activate c-Jun N-terminal Protein Kinases and Extracellular Signal-regulated Protein Kinases in Cultured Ventricular Myocytes

1995 • 212 citations

In defense of cell volume?

1993 • 194 citations

Role of calcium in astrocyte volume regulation and in the release of ions and amino acids

1993 • 185 citations

p38 Kinase Activity Is Essential for Osmotic Induction of mRNAs for HSP70 and Transporter for Organic Solute Betaine in Madin-Darby Canine Kidney Cells

1998 • 185 citations

Two Protein-tyrosine Phosphatases Inactivate the Osmotic Stress Response Pathway in Yeast by Targeting the Mitogen-activated Protein Kinase, Hog1

1997 • 173 citations

Activation of the osmo-sensitive chloride conductance involves P21rho and is accompanied by a transient reorganization of the F-actin cytoskeleton.

1996 • 171 citations

The Tyrosine Kinase p56lck Mediates Activation of Swelling-induced Chloride Channels in Lymphocytes

1998 • 161 citations

Activation of Protein Kinase Cascades by Osmotic Shock

1995 • 154 citations

Tyrosine kinase activation is an immediate and essential step in hypotonic cell swelling-induced ERK activation and c-fos gene expression in cardiac myocytes.

1996 • 152 citations

Activation of Fes Tyrosine Kinase by gp130, an Interleukin-6 Family Cytokine Signal Transducer, and Their Association

1995 • 147 citations

Phospholipase A2 as a mechanosensor

1995 • 139 citations

The Ras/Rac1/Cdc42/SEK/JNK/c-Jun Cascade Is a Key Pathway by Which Agonists Stimulate DNA Synthesis in Primary Cultures of Rat Hepatocytes

1998 • 130 citations

Cell volume and hormone action

1992 • 129 citations

Activation of extracellular signal-regulated kinases Erk-1 and Erk-2 by cell swelling in H4IIE hepatoma cells

1995 • 129 citations

Regulation of taurocholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver

1996 • 116 citations

Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver

1997 • 115 citations

Cell volume and bile acid excretion

1992 • 111 citations

Protein Kinase Signaling Pathway Triggered by Cell Swelling and Involved in the Activation of Glycogen Synthase and Acetyl-CoA Carboxylase in Isolated Rat Hepatocytes

1996 • 110 citations

Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane

1997 • 105 citations

Calcium-dependent activation of Erk-1 and Erk-2 after hypo-osmotic astrocyte swelling

1996 • 104 citations

Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver

1993 • 101 citations

Role of p38 mitogen-activated protein kinase in HIV type 1 production in vitro

1998 • 100 citations

Hypo‐osmotic cell swelling activates the p38 MAP kinase signalling cascade

1996 • 88 citations

Activation of the Janus Kinase/Signal Transducer and Activator of Transcription Pathway by Osmotic Shock

1998 • 85 citations

Control of hepatic proteolysis by amino acids

1991 • 83 citations

Cellular taurine release triggered by stimulation of the Fas(CD95) receptor in Jurkat lymphocytes

1998 • 80 citations

The stimulation of Na,K,Cl cotransport and of system A for neutral amino acid transport is a mechanism for cell volume increase during the cell cycle

1996 • 77 citations

Identification of Stathmin as a Novel Substrate for p38 Delta

1998 • 72 citations

Osmolyte Strategy in Human Monocytes and Macrophages: Involvement of p38MAPKin Hyperosmotic Induction of Betaine and Myoinositol Transporters

1998 • 71 citations

Distinctive Functions of Syk and Lyn in Mediating Osmotic Stress- and Ultraviolet C Irradiation-induced Apoptosis in Chicken B Cells

1997 • 65 citations

Hyperosmotic Induction of the Mitogen-Activated Protein Kinase Phosphatase MKP-1 in H4IIE Rat Hepatoma Cells

1998 • 62 citations

The need for a consensus agreement on indications of liver transplantation

1994 • 59 citations

Osmosignalling in C6 glioma cells

1997 • 58 citations

Osmotic regulation of the heat shock response in primary rat hepatocytes

1998 • 58 citations

Characterization of the hypo-osmolarity-induced Ca2+ response in cultured rat astrocytes

1997 • 56 citations

Characterization of the swelling-induced alkalinization of endocytotic vesicles in fluorescein isothiocyanate-dextran-loaded rat hepatocytes

1995 • 49 citations

Shrinkage-induced Protein Tyrosine Phosphorylation in Chinese Hamster Ovary Cells

1997 • 48 citations

Inhibition of hepatic proteolysis by insulin

1991 • 48 citations

Increase of c‐jun mRNA upon hypo‐osmotic cell swelling of rat hepatoma cells

1994 • 47 citations

Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in Intestine 407 cells involves the Ras/Raf-signalling pathway

1998 • 41 citations

Involvement of integrins and the cytoskeleton in modulation of skeletal muscle glycogen synthesis by changes in cell volume

1997 • 29 citations

Osmotic Regulation of MAP-Kinase Activities and Gene Expression in H4IIE Rat Hepatoma Cells

1998 • 27 citations

Effects of Anisotonic Exposure on Duck Hepatitis B Virus Replication

1994 • 27 citations

Bumetanide-sensitive cell swelling mediates the inhibitory effect of ethanol on proteolysis in rat liver☆☆☆

1998 • 25 citations

Activation of mitogen-activated protein kinases and IL-6 release in response to lipopolysaccharides in Kupffer cells is modulated by anisoosmolarity

1998 • 22 citations

Control of liver carbohydrate and fatty acid metabolism by cell volume

1994 • 19 citations

Inhibition by dihydropyridines of regulatory volume decrease and osmolyte fluxes in cultured astrocytes is unrelated to extracellular calcium

1995 • 18 citations

Compatible Organic Osmolytes and Osmotic Modulation of Inducible Nitric Oxide Synthetase in RAW 264.7 Mouse Macrophages

1998 • 16 citations

Cell volume changes modulate cholecystokinin- and carbachol-stimulated amylase release in isolated rat pancreatic acini

1997 • 12 citations

Anisoosmotic regulation of the Mi‐2 autoantigen mRNA in H4IIE rat hepatoma cells and primary hepatocytes

1998 • 11 citations

Deleted Work

1955 • 0 citations