Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

1993 • 1,102 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders

1990 • 1,001 citations

The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins.

1993 • 756 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

1993 • 659 citations

Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis

1995 • 622 citations

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

1993 • 578 citations

Limited diversity of γδ antigen receptor genes of thy-1+ dendritic epidermal cells

1988 • 522 citations

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.

1994 • 441 citations

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

1991 • 407 citations

Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction.

1994 • 395 citations

Psoriasis: a T-cell-mediated autoimmune disease induced by streptococcal superantigens?

1995 • 368 citations

Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation.

1988 • 359 citations

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

1991 • 348 citations

Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing.

1995 • 324 citations

Stratification and terminal differentiation of cultured epidermal cells

1982 • 300 citations

Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.

1993 • 263 citations

Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis.

1992 • 253 citations

Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6

1990 • 249 citations

The Keratinocyte handbook

1994 • 229 citations

Interleukin 6: insights to its function in skin by overexpression in transgenic mice.

1992 • 221 citations

Interaction of integrins alpha 3 beta 1 and alpha 2 beta 1: potential role in keratinocyte intercellular adhesion.

1993 • 210 citations

Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies.

1984 • 186 citations

Development of Disease and Virus Recovery in Transgenic Mice Containing HIV Proviral DNA

1988 • 185 citations

Integrin heterodimer and receptor complexity in avian and mammalian cells.

1989 • 156 citations

Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas.

1993 • 153 citations

Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.

1992 • 150 citations

Eyelid development, fusion and subsequent reopening in the mouse.

1993 • 144 citations

Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice.

1993 • 141 citations

Epidemiology of Psoriasis: Clinical Issues.

1994 • 139 citations

Regulation of cell surface beta 1 integrin levels during keratinocyte terminal differentiation.

1995 • 134 citations

The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis.

1993 • 114 citations

Distinct mutations in two patients with leukocyte adhesion deficiency and their functional correlates.

1990 • 105 citations

Psoriasis

1984 • 99 citations

Temporal expression of VLA-2 and modulation of its ligand specificity by rat glomerular epithelial cells in vitro.

1993 • 76 citations

Functional down-regulation of α5β1 integrin in keratinocytes is reversible but commitment to terminal differentiation is not

1993 • 53 citations

Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens.

1994 • 52 citations

Epidermal Dendritic Cell Populations in the Flaky Skin Mutant Mouse

1993 • 45 citations

Exaggerated and persistent cutaneous delayed-type hypersensitivity in transgenic mice whose epidermal keratinocytes constitutively express B7-1 antigen.

1994 • 44 citations

Integrin Expression by Human Epidermal Keratinocytes Can Be Modulated by Interferon-γ, Transforming Growth Factor-β, Tumor Necrosis Factor-α, and Culture on a Dermal Equivalent

1995 • 40 citations

Epidermal expression of intercellular adhesion molecule 1 is not a primary inducer of cutaneous inflammation in transgenic mice.

1994 • 39 citations

The involucrin genes of the mouse and the rat: study of their shared repeats.

1993 • 36 citations

Terminal differentiation-resistant epidermal cells in mice undergoing two-stage carcinogenesis.

1987 • 31 citations

The development of manifest psoriatic lesions is linked with the appearance of ICAM-1 positivity on keratinocytes

1995 • 29 citations

Expression of keratins K6 and K16 in regenerating mouse epidermis is less restricted by cell replication than the expression of K1 and K10.

1994 • 13 citations