Lysosomal accumulation of drugs in drug-sensitive MES-SA but not multidrug-resistant MES-SA/Dx5 uterine sarcoma cells

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Segregation of transferrin to a mildly acidic (pH 6.5) para-golgi compartment in the recycling pathway

1984 • 586 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Cell biological mechanisms of multidrug resistance in tumors.

1994 • 377 citations

The cell biology of multiple drug resistance

1987 • 340 citations

Molecular Pharmacology

1971 • 339 citations

Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump.

1995 • 331 citations

Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome.

1989 • 330 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

Intracellular pH and the control of multidrug resistance.

1994 • 273 citations

Defective Acidification in Human Breast Tumor Cells and Implications for Chemotherapy

1998 • 265 citations

Defective pH Regulation of Acidic Compartments in Human Breast Cancer Cells (MCF-7) Is Normalized in Adriamycin-Resistant Cells (MCF-7adr)

1996 • 258 citations

In Polarized MDCK Cells Basolateral Vesicles Arise from Clathrin-γ-adaptin–coated Domains on Endosomal Tubules

1998 • 220 citations

Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line MES-SA.

1985 • 210 citations

Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution.

1995 • 208 citations

Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif.

1993 • 205 citations

Optical microscopy for biology

1991 • 197 citations

Bafilomycin A1 Treatment Retards Transferrin Receptor Recycling More than Bulk Membrane Recycling

1997 • 170 citations

Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy.

1991 • 160 citations

Protein kinase A regulates chloride conductance in endocytic vesicles from proximal tubule

1990 • 136 citations

Vesicular Anthracycline Accumulation in Doxorubicin-Selected U-937 Cells: Participation of Lysosomes

1997 • 132 citations

Experimentally induced changes in the endocytic traffic of P-glycoprotein alter drug resistance of cancer cells

1997 • 124 citations

Acidification and Ion Permeabilities of Highly Purified Rat Liver Endosomes

1989 • 123 citations

Increased Cytosolic pH in Multidrug-Resistant Human Lung Tumor Cells: Effect of Verapamil

1989 • 120 citations

Applications of ratio fluorescence microscopy in the study of cell physiology

1994 • 105 citations

Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye.

1990 • 104 citations

Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug resistant cells expressing different levels of P-glycoprotein

1992 • 102 citations

Characterization of Acidic Vesicles in Multidrug-resistant and Sensitive Cancer Cells by Acridine Orange Staining and Confocal Microspectrofluorometry

1997 • 97 citations

Development and characterization of a human sarcoma cell line, MES-SA, sensitive to multiple drugs.

1983 • 96 citations

Thyrotropin induces the acidification of the secretory granules of parafollicular cells by increasing the chloride conductance of the granular membrane.

1988 • 94 citations

Second messengers regulate endosomal acidification in Swiss 3T3 fibroblasts.

1992 • 89 citations

Increase in Nonspecific Adsorptive Endocytosis in Anthracycline-and Vinca Alkaloid-Resistant Ehrlich Ascites Tumor Cell Lines2

1987 • 87 citations

The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected

1993 • 86 citations

Chloroquine enhancement of anticancer drug cytotoxicity in multiple drug resistant human leukemic cells

1986 • 85 citations

Multidrug-resistant Human Sarcoma Cells with a Mutant P-Glycoprotein, Altered Phenotype, and Resistance to Cyclosporins

1997 • 84 citations

Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance?

1996 • 84 citations

Biophysical Aspects of P-Glycoprotein-Mediated Multidrug Resistance

1997 • 82 citations

Increased plasma membrane traffic in daunorubicin resistant P388 leukaemic cells. Effect of daunorubicin and verapamil

1987 • 79 citations

Chapter 9 Fluorescent Labeling of Endocytic Compartments

1988 • 79 citations

Reversal by cefoperazone of resistance to etoposide, doxorubicin, and vinblastine in multidrug resistant human sarcoma cells.

1989 • 74 citations

Absence of Na+,K(+)-ATPase regulation of endosomal acidification in K562 erythroleukemia cells. Analysis via inhibition of transferrin recycling by low temperatures

1991 • 74 citations

Verapamil-mediated sensitization of doxorubicin-selected pleiotropic resistance in human sarcoma cells: selectivity for drugs which produce DNA scission.

1986 • 73 citations

Investigation of the relationship between altered intracellular pH and multidrug resistance in mammalian cells

1990 • 72 citations

Involvement of Vacuolar H+-Adenosine Triphosphatase Activity in Multidrug Resistance in HL60 Cells

1991 • 72 citations

The effect of lysosomotropic agents and secretory inhibitors on anthracycline retention and activity in multiple drug-resistant cells.

1988 • 66 citations

Functional intracellular P‐glycoprotein

1998 • 65 citations

Functional intracellular P-glycoprotein

1998 • 62 citations

Regulation of endocytic trafficking and acidification are independent of the cystic fibrosis transmembrane regulator.

1994 • 55 citations

Sequestration of doxorubicin in vesicles in a multidrug-resistant cell line (LZ-100)

1994 • 54 citations

Homotypic Lysosome Fusion in Macrophages: Analysis Using an In Vitro Assay

1997 • 53 citations

Quantification by laser scan microscopy of intracellular doxorubicin distribution

1992 • 52 citations

A mechanism for P-glycoprotein action in multidrug resistance: are we there yet?

1994 • 50 citations

Intracellular localization, vesicular accumulation and kinetics of daunorubicin in sensitive and multidrug-resistant gastric carcinoma EPG85-257 cells

1995 • 47 citations

Secretion of lysosomal enzymes by drug-sensitive and multiple drug-resistant cells.

1991 • 46 citations

The gene encoding vacuolar H+-ATPase subunit C is overexpressed in multidrug resistant HL60 cells

1992 • 44 citations

Fluorescent verapamil derivative for monitoring activity of the multidrug transporter.

1991 • 43 citations

Transfection of mu MDR 1 Inhibits Na+-Independent Cl-/-HCO3 Exchange in Chinese Hamster Ovary Cells

1994 • 40 citations

17 beta-estradiol glucuronide: an inducer of cholestasis and a physiological substrate for the multidrug resistance transporter.

1993 • 39 citations

The multidrug-resistant human lung tumour cell line, DLKP-A10, expresses novel drug accumulation and sequestration systems

1997 • 39 citations

Ultrastructural localization of daunomycin in multidrug-resistant cultured cells with modulation of the multidrug transporter.

1993 • 35 citations

Anion inhibition of the proton pump in rat liver multivesicular bodies.

1986 • 33 citations

Ratio Imaging Instrumentation

2003 • 32 citations

Altered intracellular distribution of daunorubicin in immature acute myeloid leukemia cells

1997 • 28 citations

Potential interactions between antitubulin agents and temperature: implications for modulation of multidrug resistance.

1998 • 27 citations

Metabolic conversion of methoxymorpholinyl doxorubicin: from a DNA strand breaker to a DNA cross-linker

1994 • 24 citations

ATP-Dependent Uptake of Anti-Neoplastic Agents by Acidic Organelles1

1994 • 23 citations

Characterization of adriamycin-resistant and radiation-sensitive Chinese hamster cell lines

1992 • 19 citations

Reversal of doxorubicin, etoposide, vinblastine, and taxol resistance in multidrug resistant human sarcoma cells by a polymer of spermine

1996 • 18 citations

Chapter 11 Ratio Imaging Instrumentation

1998 • 16 citations

Doxorubicin selection for MDR1/P-glycoprotein reduces swelling-activated K+ and Cl- currents in MES-SA cells

1996 • 15 citations