Gene duplications in the structural evolution of chymotrypsin

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

A solution for the best rotation to relate two sets of vectors

1976 • 2,909 citations

AREAS, VOLUMES, PACKING, AND PROTEIN STRUCTURE

1977 • 2,631 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

Carp Muscle Calcium-binding Protein

1973 • 1,359 citations

Structural patterns in globular proteins

1976 • 1,286 citations

Comparison of super-secondary structures in proteins

1973 • 885 citations

Three-dimensional structure of horse liver alcohol dehydrogenase at 2.4 Å resolution

1976 • 691 citations

Structure of crystalline α-chymotrypsin

1972 • 675 citations

Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5Å resolution: using amino acid sequence data

1975 • 638 citations

Three-dimensional Structure of Tosyl-α-chymotrypsin

1967 • 609 citations

A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S

1977 • 582 citations

β-Sheet topology and the relatedness of proteins

1977 • 541 citations

Automatic identification of secondary structure in globular proteins

1977 • 507 citations

Conformation of twisted β-pleated sheets in proteins

1973 • 487 citations

The Structure of a Bacterial Ferredoxin

1973 • 478 citations

Structure of concanavalin A at 2.4-Ang resolution

1972 • 477 citations

Structure of crystalline α-chymotrypsin

1968 • 435 citations

Three-dimensional fourier synthesis of human deoxyhaemoglobin at 2·5 Å resolution: Refinement of the atomic model

1975 • 431 citations

Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution

1974 • 431 citations

Structural evidence for gene duplication in the evolution of the acid proteases

1978 • 406 citations

Troponin and Parvalbumin Calcium Binding Regions Predicted in Myosin Light Chain and T4 Lysozyme

1975 • 374 citations

Basic Mechanisms in Blood Coagulation

1975 • 366 citations

Chymotrypsinogen: 2,5-Å crystal structure, comparison with α-chymotrypsin, and implications for zymogen activation

1970 • 345 citations

The structure of thermolysin: An electron density map at 2.3 Å resolution

1972 • 315 citations

Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus

1977 • 307 citations

Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals

1971 • 304 citations

Structure and function of haemoglobin

1968 • 302 citations

Three-dimensional Structure of Tosyl-elastase

1970 • 299 citations

Quaternary Structure of Proteins

1970 • 297 citations

The covalent and tertiary structure of bovine liver rhodanese

1978 • 292 citations

Exploring structural homology of proteins

1976 • 289 citations

The structure of horse methaemoglobin at 2.0 Å resolution

1977 • 288 citations

The structure of bovine trypsin : Electron density maps of the inhibited enzyme at 5 Å and at 2·7 Å resolution

1974 • 279 citations

Structure of human plasma prealbumin at 2.5 A resolution

1974 • 272 citations

A High Resolution Structure of an Inhibitor Complex of the Extracellular Nuclease of Staphylococcus aureus

1971 • 264 citations

Structure and function of haemoglobin

1967 • 242 citations

Crystal structure of bovine trypsinogen at 1·8 Å resolution

1977 • 242 citations

A comparison of the heme binding pocket in globins and cytochrome b5.

1975 • 237 citations

Amino-acid Sequence of Porcine Pancreatic Elastase and its Homologies with other Serine Proteinases

1970 • 219 citations

Structure and function of the constant regions of immunoglobulins

1976 • 206 citations

The cytochrome fold and the evolution of bacterial energy metabolism

1976 • 205 citations

Refinement of the model of a protein: rubredoxin at 1.5 Å resolution

1973 • 198 citations

A mathematical model-building procedure for proteins

1966 • 183 citations

Repeating Sequences and Gene Duplication in Proteins

1989 • 181 citations

Recognition of structural domains in globular proteins

1974 • 175 citations

On the conformation of proteins: The handedness of the β-strand-α-helix-β-strand unit

1976 • 175 citations

Structure of bovine trypsinogen at 1.9 Å resolution

1977 • 174 citations

Structural homology of myosin alkali light chains, troponin C and carp calcium binding protein

1974 • 171 citations

The atomic structure of crystalline porcine pancreatic elastase at 2.5 Å resolution: Comparisons with the structure of α-chymotrypsin

1978 • 165 citations

Similarity of three-dimensional structure between the immunoglobulin domain and the copper, zinc superoxide dismutase subunit

1976 • 162 citations

Three-Dimensional Structure of Hemoglobin from the Polychaete Annelid, Glycera dibranchiata, at 2.5 A Resolution

1974 • 160 citations

A mathematical procedure for superimposing atomic coordinates of proteins

1972 • 158 citations

The phylogeny of trypsin-related serine proteases and their zymogens. New methods for the investigation of distant evolutionary relationships

1975 • 152 citations

The Atomic Structure of Erythrocruorin in the Light of the Chemical Sequence and its Comparison with Myoglobin

1971 • 152 citations

Topological comparison of adenyl kinase with other proteins

1974 • 144 citations

Tertiary structural differences between microbial serine proteases and pancreatic serine enzymes

1975 • 132 citations

Structure of the lysozyme from bacteriophage T4: An electron density map at 2.4 Å resolution

1978 • 132 citations

On the conformation of proteins: The handedness of the connection between parallel β-strands

1977 • 128 citations

Structure and Symmetry of Oligomeric Enzymes

1973 • 127 citations

High resolution X-ray structure of yeast hexokinase, an allosteric protein exhibiting a non-symmetric arrangement of subunits

1976 • 121 citations

The taxonomy of protein structure

1977 • 117 citations

X-ray Crystallographic Studies of Proteins

1976 • 114 citations

Prediction of protein structure from amino acid sequence

1978 • 103 citations

I. Serine proteinases. The structure of α-chymotrypsin

1970 • 92 citations

Logical analysis of the mechanism of protein folding

1977 • 92 citations

Further improvements in the method of testing for evolutionary homology among proteins

1970 • 89 citations

Variability in the tertiary structure of α-chymotrypsin at 2.8-Å resolution

1973 • 84 citations

An evaluation of the relatedness of proteins based on comparison of amino acid sequences

1970 • 83 citations

Primary Structure of α-Lytic Protease: a Bacterial Homologue of the Pancreatic Serine Proteases

1970 • 83 citations

Structure of pyruvate kinase and similarities with other enzymes: possible implications for protein taxonomy and evolution

1978 • 81 citations

Evolution of serum albumin

1977 • 73 citations

The relation between frequencies of amino acids and ordered trinucleotides

1966 • 70 citations

Evidence suggesting a partial, internal duplication in the ancestral gene for heme-containing globins

1966 • 69 citations

The study of α-chymotrypsin by x-ray diffraction. The Third CIBA Medal Lecture

1969 • 68 citations

Molecular structure of crystalline Streptomyces griseus protease A at 2.8 å resolution

1978 • 65 citations

Comparison of homologous tertiary structures of proteins

1974 • 65 citations

Development of a Specific Anti-leukaemic Serum for the Treatment of Leukaemia in Clinics

1971 • 63 citations

Isolation and characterization of bovine factor XII (Hageman factor)

1977 • 58 citations

The double domain structure of rhodanese

1975 • 51 citations

Content of ATP and ADP in Rabbit Blastocysts

1971 • 47 citations

Isolation and characterization of bovine factor XI (plasma thromboplastin antecedent)

1977 • 46 citations

Gene Duplication in Carp Muscle Calcium Binding Protein

1972 • 40 citations

On the comparison of conformations using linear and quadratic transformations

1976 • 38 citations

Studies on the three-dimensional structure of immunoglobulins

1978 • 38 citations

The generalized inverse and inverse structure

1977 • 25 citations

A method for estimating the probability that a specific frameshift mutation was selected in the course of evolution

1970 • 13 citations

The Carboxyl-Terminal Amino Acid Sequence of Streptomyces griseus Protease A

1972 • 9 citations