Recruitment of Stat4 to the Human Interferon-α/β Receptor Requires Activated Stat2

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

1997 • 1,001 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits

1996 • 690 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

The human interferon $alpha;/$beta; receptor: Characterization and molecular cloning

1994 • 658 citations

Genetic transfer of a functional human interferon α receptor into mouse cells: Cloning and expression of its c-DNA

1990 • 582 citations

Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.

1993 • 507 citations

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

1994 • 453 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones.

1992 • 430 citations

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.

1995 • 350 citations

Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development.

1996 • 313 citations

The Role of Stat4 in Species-Specific Regulation of Th Cell Development by Type I IFNs

1998 • 300 citations

Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.

1996 • 281 citations

Role of STAT2 in the Alpha Interferon Signaling Pathway

1995 • 280 citations

High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.

1991 • 269 citations

Stat Protein Transactivation Domains Recruit p300/CBP through Widely Divergent Sequences

1999 • 228 citations

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

1994 • 211 citations

GATA-3-dependent enhancer activity in IL-4 gene regulation.

1998 • 205 citations

Functional Subdomains of STAT2 Required for Preassociation with the Alpha Interferon Receptor and for Signaling

1997 • 187 citations

Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.

1996 • 172 citations

Function of Stat2 Protein in Transcriptional Activation by Alpha Interferon

1996 • 169 citations

Ligand-Induced Association of the Type I Interferon Receptor Components

1995 • 166 citations

Cutting Edge: GATA-3-Dependent Enhancer Activity in IL-4 Gene Regulation

1998 • 158 citations

Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.

1994 • 150 citations

Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21

1993 • 113 citations

T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development.

1997 • 103 citations

Cloning and Characterization of Soluble and Transmembrane Isoforms of a Novel Component of the Murine Type I Interferon Receptor, IFNAR 2

1997 • 66 citations

Identification of a STAT4 Binding Site in the Interleukin-12 Receptor Required for Signaling

1999 • 65 citations

Differential Responsiveness of a Splice Variant of the Human Type I Interferon Receptor to Interferons

1996 • 61 citations

The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2

1995 • 58 citations

Expression of a functional human type I interferon receptor in hamster cells: application of functional yeast artificial chromosome (YAC) screening.

1994 • 55 citations

Mammalian type I interferon receptors consists of two subunits: IFNaR1 and IFNaR2

1997 • 51 citations

Urokinase Induces Activation and Formation of Stat4 and Stat1-Stat2 Complexes in Human Vascular Smooth Muscle Cells

1999 • 45 citations