Macrophages resistant to endogenously generated nitric oxide-mediated apoptosis are hypersensitive to exogenously added nitric oxide donors: Dichotomous apoptotic response independent of caspase 3 and reversal by the mitogen-activated protein kinase kinase (MEK) inhibitor PD 098059

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PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

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Social controls on cell survival and cell death

1992 • 2,641 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

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1994 • 1,698 citations

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

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Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms

1997 • 889 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

An evolutionary perspective on apoptosis

1994 • 758 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages.

1993 • 674 citations

Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

1997 • 663 citations

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

1997 • 624 citations

Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.

1996 • 535 citations

Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-Nitrosylation

1997 • 530 citations

Nitric Oxide Synthase Induces Macrophage Death by Apoptosis

1993 • 361 citations

Nitric Oxide Inhibits Fas-induced Apoptosis

1997 • 317 citations

The Shape of Cell Death

1997 • 302 citations

Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms

1996 • 288 citations

Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways

1996 • 284 citations

Posttranslational Modification of Glyceraldehyde-3-phosphate Dehydrogenase by S-Nitrosylation and Subsequent NADH Attachment

1996 • 252 citations

Apoptosis Signaling Pathway in T Cells Is Composed of ICE/Ced-3 Family Proteases and MAP Kinase Kinase 6b

1997 • 234 citations

Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system

2005 • 226 citations

Bcl-2 Protects Macrophages from Nitric Oxide-induced Apoptosis

1996 • 224 citations

Mechanism of covalent modification of glyceraldehyde‐3‐phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents

1994 • 212 citations

Inhibition of Caspase-3 by S-Nitrosation and Oxidation Caused by Nitric Oxide

1997 • 212 citations

Molecular Ordering of Apoptotic Mammalian CED-3/ICE-like Proteases

1996 • 198 citations

The Novel Cyclin-Dependent Kinase Inhibitor Flavopiridol Downregulates Bcl-2 and Induces Growth Arrest and Apoptosis in Chronic B-Cell Leukemia Lines

1997 • 197 citations

Involvement of Cellular Proteolytic Machinery in Apoptosis

1997 • 184 citations

Death substrates come alive

1997 • 167 citations

ICE-related proteases in apoptosis

1996 • 163 citations

Fas Induces Cytoplasmic Apoptotic Responses and Activation of the MKK7-JNK/SAPK and MKK6-p38 Pathways Independent of CPP32-like Proteases

1997 • 154 citations

Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis

1997 • 153 citations

Superoxide Formation and Macrophage Resistance to Nitric Oxide-mediated Apoptosis

1997 • 121 citations

Cell cycle effects of nitric oxide on vascular smooth muscle cells

1997 • 93 citations

Heat shock proteins and macrophage resistance to the toxic effects of nitric oxide

1996 • 72 citations

Nitric oxide effects on cell growth: GMP‐dependent stimulation of the AP‐1 transcription complex and cyclic GMP‐independent slowing of cell cycling

1997 • 52 citations

Nitric oxide blocks the cell cycle of mouse macrophage‐like cells in the early G₂+M phase

1994 • 47 citations

Exogenous, but not endogenous, nitric oxide increases proliferation rates in senescent human fibroblasts

1997 • 46 citations

Cytokine and Low-Level Nitric Oxide Prestimulation Block p53 Accumulation and Apoptosis of Raw 264.7 Macrophages

1996 • 37 citations

Heterologous desensitization of smooth muscle to K+ depolarization: retarded stimulus-[Ca2+]i coupling

1997 • 34 citations