The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases.

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

1995 • 1,039 citations

Efficacy of Pamidronate in Reducing Skeletal Complications in Patients with Breast Cancer and Lytic Bone Metastases

1996 • 1,023 citations

Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure.

1991 • 1,013 citations

Breast Tumor Cell Lines From Pleural Effusions2

1974 • 973 citations

Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.

1986 • 870 citations

Reduction in New Metastases in Breast Cancer with Adjuvant Clodronate Treatment

1998 • 811 citations

Pamidronate Reduces Skeletal Morbidity in Women With Advanced Breast Cancer and Lytic Bone Lesions: A Randomized, Placebo-Controlled Trial

1999 • 602 citations

Mechanism of Action

2002 • 434 citations

Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.

1987 • 434 citations

Bisphosphonates induce apoptosis in human breast cancer cell lines

2000 • 430 citations

Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.

1995 • 421 citations

Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti‐tumour activity

1997 • 408 citations

Current use of bisphosphonates in oncology. International Bone and Cancer Study Group.

1998 • 373 citations

Protein Geranylgeranylation Is Required for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI-298

2000 • 356 citations

Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices.

1997 • 349 citations

Adjuvant Clodronate Treatment Does Not Reduce the Frequency of Skeletal Metastases in Node-Positive Breast Cancer Patients: 5-Year Results of a Randomized Controlled Trial

2001 • 346 citations

Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro.

1996 • 306 citations

Bisphosphonates Induce Breast Cancer Cell Death In Vitro

2000 • 275 citations

In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates

1998 • 265 citations

Bisphosphonates Act Directly on the Osteoclast to Induce Caspase Cleavage of Mst1 Kinase during Apoptosis

1999 • 253 citations

BM 21.0955, a potent new bisphosphonate to inhibit bone resorption

1991 • 247 citations

Histopathological Evaluation of Apoptosis in Cancer

1998 • 245 citations

Clodronate decreases the frequency of skeletal metastases in women with breast cancer

1996 • 226 citations

The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.

1998 • 218 citations

Chapter 3 Assays for DNA Fragmentation, Endonucleases, and Intracellular pH and Ca2+ Associated with Apoptosis

1995 • 128 citations

Bone resorption induced by a metastatic human melanoma cell line

1995 • 54 citations

Use of bisphosphonates for the treatment of bone metastasis in experimental animal models

1999 • 53 citations

Stimulation of bone resorption results in a selective increase in the growth rate of spontaneously metastatic Walker 256 cancer cells in bone

1992 • 35 citations

Localization of parathyroid hormone-related protein in osteoclasts by in situ hybridization and immunohistochemistry

1998 • 30 citations

Drug disposition of incadronate, a new bisphosphonate, in rats with bone metastases

1997 • 13 citations