Starvation in the midst of plenty: making sense of ceramide-induced autophagy by analysing nutrient transporter expression

The Hallmarks of Cancer

2000 • 27,569 citations

Autophagy fights disease through cellular self-digestion

2008 • 6,047 citations

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

2008 • 3,730 citations

Principles of bioactive lipid signalling: lessons from sphingolipids

2008 • 3,048 citations

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

2006 • 1,840 citations

p53 Regulates Mitochondrial Respiration

2006 • 1,600 citations

AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint

2005 • 1,551 citations

Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis

2005 • 1,448 citations

Akt Stimulates Aerobic Glycolysis in Cancer Cells

2004 • 1,408 citations

DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis

2006 • 1,305 citations

Biologically active sphingolipids in cancer pathogenesis and treatment

2004 • 1,191 citations

Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance

2007 • 1,153 citations

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

2007 • 1,084 citations

Brick by brick: metabolism and tumor cell growth

2008 • 983 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

2002 • 580 citations

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism

2008 • 531 citations

Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism

2001 • 521 citations

Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and Up-regulation of Beclin 1

2004 • 422 citations

Genetic links between diet and lifespan: shared mechanisms from yeast to humans

2007 • 415 citations

Pivotal Role of the Cell Death Factor BNIP3 in Ceramide-Induced Autophagic Cell Death in Malignant Glioma Cells

2004 • 398 citations

IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival

2007 • 385 citations

Regulators of Mitotic Arrest and Ceramide Metabolism Are Determinants of Sensitivity to Paclitaxel and Other Chemotherapeutic Drugs

2007 • 378 citations

Ubiquitination and Endocytosis of Plasma Membrane Proteins: Role of Nedd4/Rsp5p Family of Ubiquitin-Protein Ligases

2000 • 356 citations

Antigen receptor–mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth

2006 • 336 citations

Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

2007 • 265 citations

Mitochondrial Ceramide and the Induction of Apoptosis

2005 • 236 citations

Thematic Review Series: Sphingolipids. New insights into sphingolipid metabolism and function in budding yeast

2008 • 222 citations

Metabolic catastrophe as a means to cancer cell death

2007 • 218 citations

Alterations of Ceramide/Sphingosine 1-Phosphate Rheostat Involved in the Regulation of Resistance to Imatinib-induced Apoptosis in K562 Human Chronic Myeloid Leukemia Cells

2007 • 214 citations

Ceramide starves cells to death by downregulating nutrient transporter proteins

2008 • 179 citations

Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand

2004 • 177 citations

Cutting Edge: IL-4-Mediated Protection of Primary B Lymphocytes from Apoptosis via Stat6-Dependent Regulation of Glycolytic Metabolism

2007 • 158 citations

Calpain is required for macroautophagy in mammalian cells

2006 • 153 citations

Rab7 Prevents Growth Factor-Independent Survival by Inhibiting Cell-Autonomous Nutrient Transporter Expression

2003 • 127 citations

Yeast sphingolipids: Recent developments in understanding biosynthesis, regulation, and function

2006 • 126 citations

Ceramide mediates caspase‐independent programmed cell death

2005 • 122 citations

Controlling cell growth and survival through regulated nutrient transporter expression

2007 • 69 citations

Ceramide, Stress, and a "LAG" in Aging

2003 • 55 citations