Thematic Review Series: Sphingolipids. New insights into sphingolipid metabolism and function in budding yeast

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

Model Systems, Lipid Rafts, and Cell Membranes

2004 • 1,625 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Biologically active sphingolipids in cancer pathogenesis and treatment

2004 • 1,191 citations

Cell Wall Integrity Signaling inSaccharomyces cerevisiae

2005 • 1,083 citations

Molecular machinery for non-vesicular trafficking of ceramide

2003 • 994 citations

Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile

2005 • 880 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Fatty acid elongases in mammals: Their regulation and roles in metabolism

2006 • 831 citations

Sch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae

2007 • 792 citations

Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism

2003 • 580 citations

Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast

2000 • 550 citations

Serine Palmitoyltransferase Is the Primary Target of a Sphingosine-like Immunosuppressant, ISP-1/Myriocin

1995 • 537 citations

ELO2 and ELO3, Homologues of theSaccharomyces cerevisiae ELO1 Gene, Function in Fatty Acid Elongation and Are Required for Sphingolipid Formation

1997 • 471 citations

When Do Lasses (Longevity Assurance Genes) Become CerS (Ceramide Synthases)?

2006 • 424 citations

Sphingolipid Synthesis as a Target for Antifungal Drugs

1997 • 396 citations

Genome-Wide Analysis of Membrane Targeting by S. cerevisiae Pleckstrin Homology Domains

2004 • 340 citations

The ins and outs of sphingolipid synthesis

2005 • 314 citations

Involvement of Yeast Sphingolipids in the Heat Stress Response of Saccharomyces cerevisiae

1997 • 294 citations

Lag1p and Lac1p Are Essential for the Acyl-CoA–dependent Ceramide Synthase Reaction inSaccharomyces cerevisae

2001 • 277 citations

C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p

2001 • 277 citations

Membrane properties of sphingomyelins

2002 • 274 citations

Endocytosis and degradation of the yeast uracil permease under adverse conditions

1994 • 266 citations

A Molecular Caliper Mechanism for Determining Very Long-Chain Fatty Acid Length

2007 • 263 citations

Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

1999 • 261 citations

Hydroxylation of Saccharomyces cerevisiae Ceramides Requires Sur2p and Scs7p

1997 • 260 citations

Functions and metabolism of sphingolipids in Saccharomyces cerevisiae

2006 • 259 citations

Sphingolipids Are Potential Heat Stress Signals inSaccharomyces

1997 • 242 citations

Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae

2000 • 241 citations

Sphingolipid functions in Saccharomyces cerevisiae

2002 • 237 citations

CERT Mediates Intermembrane Transfer of Various Molecular Species of Ceramides

2005 • 230 citations

Tsc13p Is Required for Fatty Acid Elongation and Localizes to a Novel Structure at the Nuclear-Vacuolar Interface in Saccharomyces cerevisiae

2001 • 225 citations

Tor2 Directly Phosphorylates the AGC Kinase Ypk2 To Regulate Actin Polarization

2005 • 214 citations

A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae.

1996 • 206 citations

Vesicular and nonvesicular transport of ceramide from ER to the Golgi apparatus in yeast

2001 • 205 citations

Inositol Phosphorylceramide, a Novel Substance and the Chief Member of a Major Group of Yeast Sphingolipids Containing a Single Inositol Phosphate

1974 • 203 citations

Isolation and Characterization of a Gene Affecting Fatty Acid Elongation in Saccharomyces cerevisiae

1996 • 202 citations

The Saccharomyces cerevisiae TSC10/YBR265w Gene Encoding 3-Ketosphinganine Reductase Is Identified in a Screen for Temperature-sensitive Suppressors of the Ca2+-sensitive csg2Δ Mutant

1998 • 197 citations

Tsc3p Is an 80-Amino Acid Protein Associated with Serine Palmitoyltransferase and Required for Optimal Enzyme Activity

2000 • 189 citations

Kawasaki and I

2007 • 182 citations

Pkh1 and Pkh2 Differentially Phosphorylate and Activate Ypk1 and Ykr2 and Define Protein Kinase Modules Required for Maintenance of Cell Wall Integrity

2002 • 181 citations

Regulation of Ceramide Biosynthesis by TOR Complex 2

2008 • 180 citations

Cloning of an Alkaline Ceramidase from Saccharomyces cerevisiae

2000 • 178 citations

A suppressor gene that enables Saccharomyces cerevisiae to grow without making sphingolipids encodes a protein that resembles an Escherichia coli fatty acyltransferase.

1993 • 176 citations

The phosphoinositol sphingolipids of Saccharomyces cerevisiae are highly localized in the plasma membrane

1991 • 173 citations

Cloning and Initial Characterization of a New Subunit for Mammalian Serine-palmitoyltransferase

2006 • 171 citations

Inositol Phosphorylceramide Synthase Is Located in the Golgi Apparatus ofSaccharomyces cerevisiae

2000 • 161 citations

Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

2007 • 160 citations

Identification of ISC1 (YER019w) as Inositol Phosphosphingolipid Phospholipase C inSaccharomyces cerevisiae

2000 • 159 citations

Yeast sphingolipids

1999 • 159 citations

Bioactive sphingolipids in the modulation of the inflammatory response

2006 • 157 citations

Lip1p: a novel subunit of acyl-CoA ceramide synthase

2005 • 152 citations

Cloning and Characterization of a Saccharomyces cerevisiae Alkaline Ceramidase with Specificity for Dihydroceramide

2000 • 148 citations

Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae

1999 • 147 citations

Yeast Protein Kinases and the RHO1 Exchange Factor TUS1 Are Novel Components of the Cell Integrity Pathway in Yeast

2002 • 143 citations

Syringomycin Action Gene SYR2 Is Essential for Sphingolipid 4-Hydroxylation in Saccharomyces cerevisiae

1998 • 142 citations

Sli2 (Ypk1), a Homologue of Mammalian Protein Kinase SGK, Is a Downstream Kinase in the Sphingolipid-Mediated Signaling Pathway of Yeast

2000 • 140 citations

Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton

2004 • 139 citations

The Phosphatidylinositol 4,5-Biphosphate and TORC2 Binding Proteins Slm1 and Slm2 Function in Sphingolipid Regulation

2006 • 136 citations

Differential Roles of de Novo Sphingolipid Biosynthesis and Turnover in the “Burst” of Free Sphingosine and Sphinganine, and Their 1-Phosphates and N-Acyl-Derivatives, That Occurs upon Changing the Medium of Cells in Culture

1995 • 135 citations

The Pleckstrin Homology Domain Proteins Slm1 and Slm2 Are Required for Actin Cytoskeleton Organization in Yeast and Bind Phosphatidylinositol-4,5-Bisphosphate and TORC2

2005 • 132 citations

Yeast sphingolipids: Recent developments in understanding biosynthesis, regulation, and function

2006 • 126 citations

The Sphingoid Long Chain Base Phytosphingosine Activates AGC-type Protein Kinases in Saccharomyces cerevisiae Including Ypk1, Ypk2, and Sch9

2005 • 125 citations

Mutant strains of Saccharomyces cerevisiae lacking sphingolipids synthesize novel inositol glycerophospholipids that mimic sphingolipid structures.

1993 • 123 citations

The conserved Pkh–Ypk kinase cascade is required for endocytosis in yeast

2002 • 121 citations

Heat-induced Elevation of Ceramide in Saccharomyces cerevisiae via de Novo Synthesis

1998 • 120 citations

The Saccharomyces cerevisiae YBR159w Gene Encodes the 3-Ketoreductase of the Microsomal Fatty Acid Elongase

2002 • 115 citations

A novel protein, CSG2p, is required for Ca2+ regulation in Saccharomyces cerevisiae.

1994 • 113 citations

Sphingolipids Signal Heat Stress-induced Ubiquitin-dependent Proteolysis

2000 • 112 citations

Regulation of Lipid Biosynthesis in Saccharomyces cerevisiae by Fumonisin B1

1995 • 111 citations

Slm1 and Slm2 Are Novel Substrates of the Calcineurin Phosphatase Required for Heat Stress-Induced Endocytosis of the Yeast Uracil Permease

2006 • 109 citations

Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae

1992 • 105 citations

A Saccharomyces cerevisiae Gene Required for Heterologous Fatty Acid Elongase Activity Encodes a Microsomal β-Keto-reductase

2002 • 98 citations

Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway

1988 • 97 citations

Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes

2004 • 95 citations

Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis

2000 • 95 citations

Csg1p and Newly Identified Csh1p Function in Mannosylinositol Phosphorylceramide Synthesis by Interacting with Csg2p

2003 • 94 citations

Fah1p, a Saccharomyces cerevisiae Cytochromeb 5 Fusion Protein, and ItsArabidopsis thaliana Homolog That Lacks the Cytochromeb 5 Domain Both Function in the α-Hydroxylation of Sphingolipid-associated Very Long Chain Fatty Acids

1997 • 93 citations

Isc1 regulates sphingolipid metabolism in yeast mitochondria

2007 • 92 citations

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

2007 • 90 citations

Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis

2007 • 88 citations

Very Long-chain Fatty Acid-containing Lipids rather than Sphingolipids per se Are Required for Raft Association and Stable Surface Transport of Newly Synthesized Plasma Membrane ATPase in Yeast

2006 • 87 citations

The Yeast PH Domain Proteins Slm1 and Slm2 Are Targets of Sphingolipid Signaling during the Response to Heat Stress

2006 • 82 citations

Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) inSaccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domain

1998 • 79 citations

Selective Substrate Supply in the Regulation of Yeast de Novo Sphingolipid Synthesis

2007 • 75 citations

Biosynthesis and Trafficking of Sphingolipids in the Yeast Saccharomyces cerevisiae

2002 • 70 citations

Biochemistry of the Sphingolipids. XV. Structure of Phytosphingosine and Dehydrophytosphingosine^*

1963 • 69 citations

The Uracil Transporter Fur4p Associates with Lipid Rafts

2003 • 69 citations

Biochemistry of the Sphingolipids

1964 • 68 citations

Evidence for Coupled Biogenesis of Yeast Gap1 Permease and Sphingolipids: Essential Role in Transport Activity and Normal Control by Ubiquitination

2007 • 65 citations

Activation and Localization of Inositol Phosphosphingolipid Phospholipase C, Isc1p, to the Mitochondria during Growth of Saccharomyces cerevisiae

2004 • 65 citations

Bcl-x Complements Saccharomyces cerevisiae Genes That Facilitate the Switch from Glycolytic to Oxidative Metabolism

2002 • 64 citations

Yeast sphingolipid metabolism: clues and connections

2004 • 60 citations

Expression of a Novel Marine Viral Single-chain Serine Palmitoyltransferase and Construction of Yeast and Mammalian Single-chain Chimera

2006 • 56 citations

t-SNARE Phosphorylation Regulates Endocytosis in Yeast

2002 • 56 citations

High-Performance Liquid Chromatography Analysis of Molecular Species of Sphingolipid-Related Long Chain Bases and Long Chain Base Phosphates in Saccharomyces cerevisiae after Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate

2001 • 55 citations

Raft Partitioning of the Yeast Uracil Permease During Trafficking Along the Endocytic Pathway

2003 • 54 citations

The Phosphatidylglycerol/Cardiolipin Biosynthetic Pathway Is Required for the Activation of Inositol Phosphosphingolipid Phospholipase C, Isc1p, during Growth of Saccharomyces cerevisiae

2004 • 50 citations

Glycosphingolipidoses: Beyond the enzymatic defect

2004 • 48 citations

Disturbance of Sphingolipid Biosynthesis Abrogates the Signaling of Mss4, Phosphatidylinositol-4-phosphate 5-Kinase, in Yeast

2005 • 47 citations

Yeast sphingolipids do not need to contain very long chain fatty acids

2006 • 43 citations

Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae

2006 • 43 citations

Regulation of the Transport and Protein Levels of the Inositol Phosphorylceramide Mannosyltransferases Csg1 and Csh1 by the Ca2+-binding Protein Csg2

2007 • 40 citations

Lipid-dependent surface transport of the proton pumping ATPase: A model to study plasma membrane biogenesis in yeast

2006 • 40 citations

Loss of Ypk1 Function Causes Rapamycin Sensitivity, Inhibition of Translation Initiation and Synthetic Lethality in 14-3-3-Deficient Yeast

2002 • 39 citations

ISC1‐encoded inositol phosphosphingolipid phospholipase C is involved in Na⁺/Li⁺ halotolerance of Saccharomyces cerevisiae

2002 • 35 citations

The role of lipids in the biogenesis of integral membrane proteins

2006 • 34 citations

Intracellular transport of inositol‐containing sphingolipids in the yeast, Saccharomyces cerevisiae

1995 • 29 citations

SVF1 Regulates Cell Survival by Affecting Sphingolipid Metabolism in Saccharomyces cerevisiae

2006 • 18 citations

Ceramide: From Embryos to Tumors

2007 • 12 citations

12 Baker’s Yeast: a rising foundation for eukaryotic sphingolipid-mediated cell signaling

2003 • 4 citations