Intercellular signaling and the polarization of body axes during Drosophila oogenesis.

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

The origin of pattern and polarity in the Drosophila embryo

1992 • 1,367 citations

Notch Signaling

1995 • 1,282 citations

Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

1985 • 1,063 citations

Developmental genetics of oogenesis

1993 • 858 citations

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

1991 • 770 citations

Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product

1985 • 675 citations

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

1990 • 675 citations

The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein.

1993 • 567 citations

The suppressor of hairless protein participates in notch receptor signaling

1994 • 547 citations

Polarization of both major body axes in Drosophila by gurken-torpedo signalling

1995 • 485 citations

cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila

1995 • 480 citations

Reorganization of the cytoskeleton during Drosophila oogenesis: implications for axis specification and intercellular transport

1992 • 399 citations

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.

1990 • 389 citations

Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster

1987 • 373 citations

Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila

1991 • 372 citations

SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO

1995 • 348 citations

A dual function of the Notch gene in Drosophila sensillum development

1990 • 333 citations

The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo

1994 • 321 citations

The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.

1994 • 320 citations

The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway.

1993 • 320 citations

The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats

1987 • 317 citations

Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.

1995 • 312 citations

Isolation and characterization of fission yeast mutants defective in the assembly and placement of the contractile actin ring

1996 • 311 citations

Autosomal P[ovo D1 ] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras

1993 • 302 citations

Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte

1994 • 293 citations

Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte

1989 • 291 citations

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

1992 • 288 citations

The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.

1992 • 278 citations

Microtubules mediate the localization of bicoid RNA during Drosophila oogenesis

1991 • 255 citations

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos

1995 • 251 citations

Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates.

1988 • 251 citations

cappuccino and spire: two unique maternal-effect loci required for both the anteroposterior and dorsoventral patterns of the Drosophila embryo.

1989 • 246 citations

A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis

1993 • 226 citations

The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.

1990 • 222 citations

Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization

1995 • 211 citations

Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway

1994 • 209 citations

The Drosophila EGF receptor gene homolog: Conservation of both hormone binding and kinase domains

1985 • 202 citations

cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos

1991 • 187 citations

orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis.

1994 • 187 citations

Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis.

1994 • 182 citations

The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs

1991 • 179 citations

The Drosophila orb gene is predicted to encode sex-specific germline RNA-binding proteins and has localized transcripts in ovaries and early embryos

1992 • 165 citations

Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo

1990 • 160 citations

Cappuccino, a Drosophila maternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus.

1995 • 159 citations

Drosophila cytoplasmic dynein, a microtubule motor that is asymmetrically localized in the oocyte.

1994 • 157 citations

Homeless is required for RNA localization in Drosophila oogenesis and encodes a new member of the DE-H family of RNA-dependent ATPases.

1995 • 156 citations

Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis

1993 • 149 citations

How Fission Yeast Fission in the Middle

1996 • 139 citations

Initial organization of the Drosophila dorsoventral axis depends on an RNA-binding protein encoded by the squid gene.

1993 • 139 citations

Regulated synthesis, transport and assembly of the Drosophila germ plasm

1996 • 136 citations

Multiple effects of colchicine on oogenesis in Drosophila: Induced sterility and switch of potential oocyte to nurse-cell developmental pathway

1983 • 136 citations

Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene.

1988 • 131 citations

RNA localization along the anteroposterior axis of the Drosophila oocyte requires PKA-mediated signal transduction to direct normal microtubule organization.

1994 • 124 citations

fs(1)K10, a germline-dependent female sterile mutation causing abnormal chorion morphology inDrosophila melanogaster

1978 • 121 citations

torso-like encodes the localized determinant of Drosophila terminal pattern formation.

1993 • 116 citations

Dorsoventral axis formation in Drosophila depends on the correct dosage of the gene gurken

1994 • 115 citations

Role of Oocyte Position in Establishment of Anterior-Posterior Polarity in Drosophila

1994 • 115 citations

The relationship between ovarian and embryonic dorsoventral patterning in Drosophila

1994 • 113 citations

Behaviour of cells mutant for an EGFreceptorhomologue ofDrosophilain genetic mosaics

1990 • 110 citations

An unusual mosaic protein with a protease domain, encoded by the nudeI gene, is involved in defining embryonic dorsoventral polarity in Drosophila

1995 • 109 citations

Delta Function Is Required for Bristle Organ Determination and Morphogenesis in Drosophila

1993 • 106 citations

The neurogenic locus brainiac cooperates with the Drosophila EGF receptor to establish the ovarian follicle and to determine its dorsal-ventral polarity

1992 • 99 citations

Similarities between trunk and spätzle, putative extracellular ligands specifying body pattern in Drosophila.

1995 • 77 citations

The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGFα-like protein

1993 • 76 citations

The torpedo (DER) receptor tyrosine kinase is required at multiple times during Drosophila embryogenesis

1992 • 73 citations

The role of microtubules in the differentiation of ovarian follicles during vitellogenesis inDrosophila

1986 • 67 citations

A Drosophila genomic sequence with homology to human epidermal growth factor receptor

1985 • 66 citations

A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases.

1994 • 60 citations

The daughterless gene functions together with Notch and Delta in the control of ovarian follicle development in Drosophila

1994 • 60 citations

Essential role for a heterogeneous nuclear ribonucleoprotein (hnRNP) in oogenesis: hrp40 is absent from the germ line in the dorsoventral mutant squid.

1994 • 57 citations

Expression of Drosophila epidermal growth factor receptor homologue in mitotic cell populations

1987 • 49 citations

Role of the oocyte nucleus in determination of the dorsoventral polarity of Drosophila as revealed by molecular analysis of the K10 gene

1988 • 44 citations

The torso pathway in Drosophila: a model system to study receptor tyrosine kinase signal transduction

1993 • 42 citations

Interallelic complementation among DER/flb alleles: implications for the mechanism of signal transduction by receptor-tyrosine kinases.

1991 • 40 citations

Mechanisms of dorsal-ventral axis determination in Drosophila embryos revealed by cytoplasmic transplantations

1993 • 29 citations

The spatial arrangement of germ line cells in ovarian follicles of the mutantdicephalic inDrosophila melanogaster

1984 • 29 citations

Axis Determination: Proteolytic generation of a morphogen

1994 • 19 citations

Deleted Work

1955 • 0 citations