Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5′-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Critical nodes in signalling pathways: insights into insulin action

2006 • 2,581 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 • 2,561 citations

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

2004 • 2,039 citations

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

2004 • 1,631 citations

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

2001 • 950 citations

AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling

2002 • 829 citations

The Two TORCs and Akt

2007 • 782 citations

The Molecular Bases of Training Adaptation

2007 • 701 citations

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1

2006 • 650 citations

Health consequences of obesity in the elderly: a review of four unresolved questions

2005 • 639 citations

mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes

2005 • 621 citations

The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity

2006 • 603 citations

Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance

2004 • 536 citations

Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 IsMediated by p70S6 Kinase

2005 • 535 citations

Amino Acid and Insulin Signaling via the mTOR/p70 S6 Kinase Pathway

2001 • 529 citations

Bidirectional modulation of insulin action by amino acids.

1998 • 491 citations

Selective activation of AMPK‐PGC‐1α or PKB‐TSC2‐mTOR signaling can explain specific adaptive responses to endurance or resistance training‐like electrical muscle stimulation

2005 • 472 citations

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

2007 • 446 citations

Exercise training‐induced improvements in insulin action

2007 • 418 citations

Insulin signal transduction through protein kinase cascades.

1998 • 364 citations

Early signaling responses to divergent exercise stimuli in skeletal muscle from well‐trained humans

2005 • 333 citations

Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance

2004 • 328 citations

Lactic Acid Efflux from White Skeletal Muscle Is Catalyzed by the Monocarboxylate Transporter Isoform MCT3

1998 • 293 citations

Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise

2002 • 289 citations

Interaction between free fatty acids and glucose metabolism

2002 • 221 citations

The Mammalian Target of Rapamycin Pathway Regulates Nutrient-Sensitive Glucose Uptake in Man

2007 • 215 citations

Role of Insulin, Adipocyte Hormones, and Nutrient-Sensing Pathways in Regulating Fuel Metabolism and Energy Homeostasis: A Nutritional Perspective of Diabetes, Obesity, and Cancer

2006 • 212 citations

Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling

2007 • 211 citations

Muscle-Specific Deletion of Rictor Impairs Insulin-Stimulated Glucose Transport and Enhances Basal Glycogen Synthase Activity

2007 • 207 citations

Selective Control of Skeletal Muscle Differentiation by Akt1

2007 • 117 citations

Changes in signalling pathways regulating protein synthesis in human muscle in the recovery period after endurance exercise

2007 • 115 citations

Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation

2006 • 115 citations

Differential activation of mTOR signaling by contractile activity in skeletal muscle

2003 • 114 citations

Interaction between the AMP-Activated Protein Kinase and mTOR Signaling Pathways

2006 • 106 citations

Tissue-Specific Effects of Rosiglitazone and Exercise in the Treatment of Lipid-Induced Insulin Resistance

2007 • 104 citations

Regulation of glucose transport in skeletal muscle ¹

1992 • 99 citations

Exercise‐induced alterations in extracellular signal‐regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle

2006 • 98 citations

Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes

2007 • 83 citations

Nutrient sensor links obesity with diabetes risk

2004 • 71 citations

Prolonged exposure to palmitate impairs fatty acid oxidation despite activation of AMP‐activated protein kinase in skeletal muscle cells

2008 • 69 citations

Signalling mechanisms in skeletal muscle: role in substrate selection and muscle adaptation

2006 • 68 citations

Chronic rosiglitazone treatment restores AMPKα2 activity in insulin-resistant rat skeletal muscle

2005 • 61 citations

Effect of Testosterone on Insulin Stimulated IRS1 Ser Phosphorylation in Primary Rat Myotubes—A Potential Model for PCOS-Related Insulin Resistance

2009 • 60 citations

In Rat Hepatocytes Glucagon Increases Mammalian Target of Rapamycin Phosphorylation on Serine 2448 but Antagonizes the Phosphorylation of Its Downstream Targets Induced by Insulin and Amino Acids

2004 • 52 citations

Potentiation of insulin-stimulated glucose transport by the AMP-activated protein kinase

2006 • 48 citations

Role of Adenosine 5′-Monophosphate-Activated Protein Kinase Subunits in Skeletal Muscle Mammalian Target of Rapamycin Signaling

2008 • 47 citations

A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle

2008 • 45 citations

Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle

2007 • 42 citations

Insulin signal transduction through protein kinase cascades

1998 • 39 citations

Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles ofob/obmice

2008 • 35 citations