The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations

Apoptosis by Death Factor

1997 • 5,038 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids

1990 • 1,173 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1998 • 504 citations

FasGene Mutations in the Canale–Smith Syndrome, an Inherited Lymphoproliferative Disorder Associated with Autoimmunity

1996 • 486 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing.

1995 • 398 citations

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

1996 • 379 citations

Clinical, Immunologic, and Genetic Features of an Autoimmune Lymphoproliferative Syndrome Associated With Abnormal Lymphocyte Apoptosis

1997 • 374 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease.

1992 • 310 citations

Large differences in the helix propensities of alanine and glycine

1991 • 307 citations

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

1997 • 256 citations

Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis.

1997 • 177 citations

Deficiency of the Fas Apoptosis Pathway Without Fas Gene Mutations in Pediatric Patients With Autoimmunity/Lymphoproliferation

1997 • 177 citations

Missense Mutations in the Fas Gene Resulting in Autoimmune Lymphoproliferative Syndrome: A Molecular and Immunological Analysis

1997 • 168 citations

Chronic lymphadenopathy simulating malignant lymphoma

1966 • 159 citations

Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome.

1995 • 130 citations

Novel Fas (CD95/APO-1) mutations in infants with a lymphoproliferative disorder.

1998 • 99 citations

Separate Domains of the Human Fas Ligand Dictate Self-association and Receptor Binding

1997 • 82 citations

Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis

1997 • 62 citations

Requirement of Cysteine-rich Repeats of the Fas Receptor for Binding by the Fas Ligand

1997 • 59 citations

Phosphorylation of FADD/MORT1 and Fas by Kinases That Associate with the Membrane-Proximal Cytoplasmic Domain of Fas

1998 • 43 citations

Patients with systemic lupus erythematosus with high plasma levels of sFas risk relapse.

1999 • 26 citations

A three-dimensional model of the Fas/APO-1 molecule: cross-reactivity of anti-Fas antibodies explained by structural mimicry of antigenic sites.

1998 • 22 citations

Distinctive Expression of Iprcg in the Heterozygous State on Different Genetic Backgrounds

1993 • 16 citations

Genotype‐restricted lymphoproliferation in autoimmune lpr mice

1991 • 14 citations

Hereditary splenomegaly with hypersplenism

1974 • 12 citations

Lymphadenopathy induced by the cooperation between lpr^cg and gld genes is of lpr but not of gld phenotype

1994 • 5 citations