Cellular discriminants for a biological classification of human colon carcinoma.

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

The pathogenesis of cancer metastasis

1980 • 1,750 citations

The classification of cancer of the rectum

1932 • 1,529 citations

Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor

1977 • 1,422 citations

THE PROGNOSTIC SIGNIFICANCE OF DIRECT EXTENSION OF CARCINOMA OF THE COLON AND RECTUM

1954 • 1,110 citations

Classification of human colorectal adenocarcinoma cell lines.

1976 • 943 citations

Tumor heterogeneity and the biology of cancer invasion and metastasis.

1978 • 833 citations

Flow cytometry in clinical cancer research.

1983 • 764 citations

Clonal origin of human tumors

1976 • 662 citations

Heterogeneity of malignant cells from a human colonic carcinoma.

1981 • 468 citations

DNA distribution in human colon carcinomas and its relationship to clinical behavior.

1982 • 370 citations

Concepts for systemic treatment of micrometastases

1975 • 338 citations

Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells.

1981 • 304 citations

Cellular DNA content as a marker of neoplasia in man

1980 • 302 citations

Prognostic significance of modal DNA value and other factors in malignant tumours, based on 1465 cases

1979 • 281 citations

Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor.

1978 • 281 citations

Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line.

1976 • 277 citations

Development and Biologic Properties of Malignant Cell Sublines and Clones of a Spontaneously Metastasizing Rat Mammary Adenocarcinoma<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 253 citations

The regulation and function of ornithine decarboxylase and of the polyamines.

1979 • 247 citations

DNA in Human Tumors: A Cytophotometric Study

1975 • 241 citations

Establishment and characterization of an in vitro model system for human adenocarcinoma of the stomach.

1983 • 229 citations

Carcinoembryonic antigen (CEA) in gastrointestinal and extragastrointestinal tumors and its relationship to tumor‐cell differentiation

1972 • 184 citations

Clonal heterogeneity of small-cell anaplastic carcinoma of the lung demonstrated by flow-cytometric DNA analysis.

1980 • 175 citations

THE GRADING AND PROGNOSIS OF CARCINOMA OF THE COLON AND RECTUM

1939 • 167 citations

Heterogeneity of cancer cells from a single human colon carcinoma

1981 • 167 citations

Differential killing efficacy of twenty antitumor drugs on proliferating and nonproliferating human tumor cells.

1981 • 149 citations

Phenotypic drift of metastatic and cell‐surface properties of mammary adenocarcinoma cell clones during growth in vitro

1981 • 143 citations

Differences in drug sensitivity among tumor cells from parental tumors, selected variants, and spontaneous metastases.

1981 • 140 citations

Cell surface properties of B16 melanoma variants with differing metastatic potential.

1980 • 134 citations

Chromosomal banding patterns in human large bowel cancer

1981 • 130 citations

Growth interaction in vivo between tumor subpopulations derived from a single mouse mammary tumor.

1980 • 128 citations

The Use of Preoperative Plasma CEA Levels for the Stratification of Patients After Curative Resection of Colorectal Cancers

1980 • 126 citations

Prognostic implications of ploidy and proliferative activity in human solid tumors

1982 • 123 citations

Biology of the human malignant lymphomasIII. Intracranial heterotransplantation in the nude, athymic mouse

1976 • 122 citations

Implications of immunological heterogeneity of tumours

1979 • 117 citations

Interactions between tumor subpopulations affecting their sensitivity to the antineoplastic agents cyclophosphamide and methotrexate.

1981 • 111 citations

Prognostic factors in colon carcinoma

1975 • 110 citations

Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions

1981 • 110 citations

The Nude Mouse in Experimental and Clinical Research

1982 • 109 citations

Immunocytochemical Localization of Carcinoembryonic Antigen in Benign and Malignant Colorectal Tissues: Assessment of Diagnostic Value

1981 • 108 citations

Immunofluorescent detection of estrogen receptors in breast cancer.Comparison with dextran-coated charcoal and sucrose gradient assays

1978 • 105 citations

Correlation of plasma CEA and CEA tissue staining in poorly differentiated colorectal cancer

1981 • 105 citations

Large-Bowel Cancer—The Current Status of Treatment

1976 • 99 citations

The origin of metastatic heterogeneity in tumors

1981 • 98 citations

Automatic processing and interpretation of DNA distributions: Comparison of several techniques

1978 • 97 citations

Tumor cell antigenicity, host immunity, and cancer metastasis

1980 • 96 citations

Retrograde intramural spread of carcinoma of the rectum and rectosigmoid; a microscopic study.

1953 • 96 citations

Differential sensitivites of human melanoma cells grown in vitro to arabinosylcytosine.

1972 • 95 citations

Inhibition of the platelet-aggregating activity of two human adenocarcinomas of the colon and an anaplastic murine tumor with a specific thrombin inhibitor, dansylarginine N-(3-ethyl-1,5-pentanediyl)amide.

1981 • 95 citations

Immunologic Heterogeneity of Tumor Cell Subpopulations From a Single Mouse Mammary Tumor<xref ref-type="fn" rid="FN2">2</xref>

1979 • 93 citations

Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice

1978 • 88 citations

Cancer cell estrogen receptor of human mammary carcinoma

1979 • 85 citations

Biological and experimental consequences of the zonal composition of solid tumors.

1981 • 79 citations

S-phase fractions of colorectal carcinomas related to pathologic and clinical features

1981 • 79 citations

Large-bowel carcinomas with different ploidy, related to secretory component, IgA, and CEA in epithelium and plasma

1982 • 77 citations

Subpopulations of breast carcinoma defined by S-phase fraction, morphology, and estrogen receptor content.

1978 • 77 citations

Localization and Concentration of Carcinoembryonic Antigen (CEA) in Gastrointestinal Tumors: Correlation With CEA Levels in Plasma<xref ref-type="fn" rid="fn2">2</xref>

1981 • 76 citations

Prognostic significance of vascular invasion in colorectal cancer of Dukes' B class

1977 • 73 citations

Tight Junctions in Epithelial Cells of Human Fetal Hindgut, Normal Colon, and Colon Adenocarcinoma<xref ref-type="fn" rid="FN2">2</xref>

1980 • 73 citations

Tumor heterogeneity and stability of the metastatic phenotype of mouse KHT sarcoma cells.

1981 • 72 citations

Effect of sodium butyrate on carcinoembryonic antigen production by human colonic adenocarcinoma cells in culture.

1983 • 69 citations

Heterogeneous response and clonal drift of sensitivities of metastatic 13762NF mammary adenocarcinoma clones to gamma-radiation in vitro.

1983 • 66 citations

A possible involvement of polyamines in the initiation of DNA synthesis by human WI‐38 and mouse BALB/3T3 cells

1976 • 60 citations

Antigenic differences among osteogenic sarcoma tumor cells taken from different locations in human tumors.

1977 • 58 citations

Prognosis and surgical pathology of carcinoma of the colon.

1973 • 56 citations

Characterization of a variant-producing tumor cell line from a heterogeneous strain BALB/cfC3H mouse mammary tumor.

1981 • 56 citations

Differential response by human melanoma cells to 1,3-bis-(2-chloroethyl)-1-nitrosourea and bleomycin

1973 • 55 citations

Differential sensitivities of five rat hepatoma cell lines to anticancer drugs.

1978 • 54 citations

Staging of cancer of the colon and cancer of the rectum

1979 • 53 citations

The DNA Content of Tumor Cells. I. Polyps and Adenocarcinomas of the Large Intestine of Man

1960 • 53 citations

Detection by Immunofluorescence of Carcinoembryonic Antigen in Colonic Carcinoma, Other Malignant or Benign Tumours, and Non-Cancerous Tissues

1973 • 53 citations

Isolation of a cellular subpopulation from a human colonic carcinoma cell line.

1980 • 51 citations

Cultured Human Tumour Cells May Be Arrested In All Stages of the Cycle During Stationary Phase: Demonstration of Quiescent Cells In G₁, S and G₂ Phase

1984 • 49 citations

Evaluation of a New Radioimmunoassay Method for Carcinoembryonic Antigen in Plasma, with Use of Zirconyl Phosphate Gel

1972 • 48 citations

Karyotype consistency in human colorectal carcinoma cell lines established in vitro

1982 • 47 citations

First British standard for carcinoembryonic antigen (CEA)

1975 • 47 citations

In vitro labeling and gold activation autoradiography for determination of labeling index and DNA synthesis times of solid tumors.

1976 • 46 citations

Lack of effectiveness of combined 5-fluorouracil and methyl-ccnu therapy in advanced colorectal cancer

1977 • 46 citations

Growth and regression of human tumor cell lines in congenitally athymic (rnu/rnu) rats.

1981 • 45 citations

Estimation of tumor growth fraction in murine tumors by the primer-available DNA-dependent DNA polymerase assay.

1976 • 44 citations

Heterogeneity in hyperthermic sensitivities of rat 13762NF mammary adenocarcinoma cell clones of differing metastatic potentials.

1982 • 43 citations

Further Biologic Characteristics of a Human Carcinoembryonic Antigen-Producing Colon Carcinoma Cell Line2

1978 • 41 citations

Longitudinal karyotype and genetic signature analysis of cultured human colon adenocarcinoma cell lines LS180 and LS174T.

1980 • 41 citations

Polyamines and biosynthetic enzymes in the rat intestinal mucosa and the influence of methylglyoxal-bis(guanylhydrazone).

1980 • 41 citations

Antigenic Heterogeneity of Human Colorectal Cancer Cell Lines Analyzed by a Panel of Monoclonal Antibodies. I. Heterogeneous Expression of la-Like and HLA-Like Antigenic Determinants<xref ref-type="fn" rid="fn2">2</xref>

1982 • 40 citations

Variants of a human colon adenocarcinoma cell line which differ in morphology and carcinoembryonic antigen production.

1977 • 38 citations

Intracranial heterotransplantation of human hematopoietic cells in nude mice

1979 • 38 citations

Immunohistological patterns of carcinoembryonic antigen in colorectal carcinoma. Correlation with staging and blood levels

1980 • 36 citations

Heterogeneity of human adenocarcinomas of the colon and the stomach as regards sensitivity to cytostatic drugs.

1975 • 36 citations

Evolution in the pathologic staging of carcinoma of the colon.

1978 • 35 citations

Radiation Response of Clonogenic Cell Populations Separated from a Fibrosarcoma

1975 • 35 citations

AUTORADIOGRAPHIC DETECTION OF DNA POLYMERASE CONTAINING NUCLEI IN SARCOMA 180 ASCITES CELLS

1973 • 33 citations

Athymic Nude Rats

1981 • 33 citations

The effect of target cell differentiation on human natural killer cell activity: a specific defect in target cell binding and early activation events.

1982 • 32 citations

Relationship Between Chromosome Ploidy and Radiosensitivity in Selected Tumor Sublines of Common Origin<xref ref-type="fn" rid="FN1">2</xref>

1960 • 30 citations

Characterization of two metastatic subpopulations originating from a single human colon carcinoma.

1983 • 29 citations

Detection and Analysis of a Glucose 6-Phosphate Dehydrogenase Phenotype B Cell Line Contamination2

1979 • 26 citations

Biological and cell kinetic properties of a human colonic adenocarcinoma (LoVo) grown in athymic mice.

1980 • 26 citations

Growth kinetics of human large bowel cancer growing in immune-deprived mice and some chemotherapeutic observations

2006 • 26 citations

Restriction of CEA synthesis to the stationary phase of growth of cultured human colon carcinoma cells

1976 • 25 citations

Growth of human digestive-tumour xenografts in athymic nude rats

1981 • 25 citations

Interactions between tumor cell subpopulations in malignant tumors.

1983 • 24 citations

Carcinoembryonic antigen production by human colorectal adenocarcinoma cells in matrix-perfusion culture

1980 • 24 citations

Correlation of cell cycle analysis with Duke's staging in colon cancer patients

1980 • 23 citations

Various Isozyme Gene Expression Patterns Among Human Colorectal Adenocarcinoma Cell Lines and Tissues<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1982 • 22 citations

Mammary tumor heterogeneity.

1983 • 21 citations

Flow cytometric analysis of DNA content for ploidy determination in human solid tumors.

1979 • 20 citations

Characteristic differences in clones isolated from an S37 ascites tumor in vitro

1967 • 19 citations

Human colorectal carcinoma: Patterns of sensitivity to chemotherapeutic agents in the human tumor stem cell assay

1982 • 19 citations

Human colonic tumor cell kinetics.Potential for therapy

1977 • 18 citations

Growth characteristics of human colonic adenocarcinomas propagated in the Rowett athymic rat.

1982 • 16 citations

Cytogenetic analysis of human tumor cells cloned in agar.

1980 • 16 citations

In vitro growth and drug sensitivity of tumor colony-forming units from human tumor xenografts.

1981 • 16 citations

Response to X-radiation and cytotoxic drugs of clonal subpopulations of different ploidy and metastatic potential isolated from RIF-1 mouse sarcoma

1983 • 16 citations

ARH-77, an established human IgG-producing myeloma cell line. II. growth kinetics, clonogenic capacity, chalone production, xenogeneic transplantations, and response to melphalan

1984 • 15 citations

[Immunohistochemical detection of carcinoembryonic antigen].

1981 • 15 citations

Intracranial Growth of Pulmonary Small Cell Carcinoma Cells in Nude Athymic Mice

1981 • 12 citations

Why Do Colon Tumours Respond Poorly to Chemotherapeutic Agents?

1981 • 12 citations

Comparison of cell peripheries in the human colonic adenocarcinoma cell lines SW480 and SW620 grown in floating chamber culture, cover slip culture, athymic (nude) mice, and BALB/c mice.

1981 • 11 citations

Analysis of natural killer cell activity in random-bred Rowett athymic rats.

1984 • 10 citations

In vitro cellular characteristics and survival responses of human astrocytoma clones to chloroethyl-nitrosoureas and dianhydrogalactitol

1983 • 10 citations

Biological properties of the human colonic adenocarcinoma cell line SW 620 grown as a xenograft in the athymic mouse.

1981 • 8 citations

Heterogeneity in human colon cancer.

1983 • 4 citations

A procedure for the application of cell kinetic techniques to human tumor samples

1980 • 3 citations

Characteristics of seven clones of the WiDr human colon adenocarcinoma cell line

1982 • 2 citations