β-Amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation

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Alzheimer's Disease: Genes, Proteins, and Therapy

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Inflammation and Alzheimer's disease

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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

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Pathobiology of ischaemic stroke: an integrated view

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

1997 • 1,970 citations

Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>

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Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease

1996 • 1,371 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

1999 • 1,027 citations

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

1998 • 974 citations

Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics

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Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease

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Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

1996 • 760 citations

Vascular risk factors for Alzheimer’s disease:

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Inflammation and Stroke: Putative Role for Cytokines, Adhesion Molecules and iNOS in Brain Response to Ischemia

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Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E

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p38 MAPK signalling cascades in inflammatory disease

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The role of cerebral ischemia in Alzheimer’s disease

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Cerebral ischemia and inflammation

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ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models

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SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

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Formation of β-amyloid protein deposits in brains of transgenic mice

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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38

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Alzheimer's disease: a re-examination of the amyloid hypothesis

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The Effects of Additional Pathology on the Cognitive Deficit in Alzheimer Disease

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SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.

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Inflammation of the brain in Alzheimer's disease: implications for therapy

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Aging-induced Up-regulation of Nuclear Binding Activities of Oxidative Stress Responsive NF-kB Transcription Factor in Mouse Cardiac Muscle

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The role of complement and activated microglia in the pathogenesis of Alzheimer's disease

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Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein

1997 • 200 citations

Exogenous Aβ1–40 Reproduces Cerebrovascular Alterations Resulting from Amyloid Precursor Protein Overexpression in Mice

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p38 Activation Is Required Upstream of Potassium Current Enhancement and Caspase Cleavage in Thiol Oxidant-Induced Neuronal Apoptosis

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Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques

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Inhibition of Ultraviolet B-induced Activator Protein-1 (AP-1) Activity by Aspirin in AP-1-Luciferase Transgenic Mice

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Effect of Lactacidosis on Pyridine Nucleotide Stability During Ischemia in Mouse Brain

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Inflammation After Stroke

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Microglia and Alzheimer’s disease

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Regulation and Expression of the Alzheimer's β/A4 Amyloid Protein Precursor in Health, Disease, and Down's Syndromea

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Molecular Pathology of Cerebral Ischemia: Delayed Gene Expression and Strategies for Neuroprotection^a

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Transgenic mouse brain histopathology resembles early Alzheimer's disease

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Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice

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Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for beta-APP751.

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Mechanisms Underlying Neuronal Death Induced by Chromogranin A-activated Microglia

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Neurocytopathic effects of beta-amyloid-stimulated monocytes: a potential mechanism for central nervous system damage in Alzheimer disease.

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Clinical Pharmacology of Cerebral Ischemia

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Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease

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Etiology and pathogenesis of Alzheimer’s disease

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Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration

1999 • 10 citations

The Clinical Pharmacology of Cerebral Ischemia.

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