Transcriptional regulation of scar gene expression in primary astrocytes
Data up to Jan 2025
Total Citations Per Year
Abstract
References (64)
Regeneration beyond the glial scar
2004 • 2,896 citations
Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor
1999 • 2,386 citations
Chondroitinase ABC promotes functional recovery after spinal cord injury
2002 • 2,236 citations
The glial scar and central nervous system repair
1999 • 1,757 citations
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene
1994 • 1,573 citations
Molecular profile of reactive astrocytes—Implications for their role in neurologic disease
1993 • 1,436 citations
Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes
1991 • 1,171 citations
A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes
1993 • 1,166 citations
SOX9 Is a Potent Activator of the Chondrocyte-Specific Enhancer of the Proα1(II) Collagen Gene
1997 • 1,051 citations
Regeneration of adult axons in white matter tracts of the central nervous system
1997 • 747 citations
Neurite extension by peripheral and central nervous system neurons in response to substratum-bound fibronectin and laminin
1983 • 672 citations
Molecular insights into renal interstitial fibrosis.
1996 • 636 citations
Robust Regeneration of Adult Sensory Axons in Degenerating White Matter of the Adult Rat Spinal Cord
1999 • 608 citations
The Sox9 transcription factor determines glial fate choice in the developing spinal cord
2003 • 604 citations
The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury
2003 • 531 citations
The Chondroitin Sulfate Proteoglycans Neurocan and Phosphacan Are Expressed by Reactive Astrocytes in the Chronic CNS Glial Scar
1999 • 473 citations
Neurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes
2000 • 472 citations
Chapter 22 Chondroitin sulphate proteoglycans in the CNS injury response
2002 • 415 citations
The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury
1995 • 402 citations
The glial scar: its bearing on axonal elongation and transplantation approaches to CNS repair.
1988 • 362 citations
Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells.
1991 • 331 citations
N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro.
1988 • 326 citations
Smad3 Induces Chondrogenesis through the Activation of SOX9 via CREB-binding Protein/p300 Recruitment
2004 • 307 citations
Degradation of Chondroitin Sulfate Proteoglycan Enhances the Neurite-Promoting Potential of Spinal Cord Tissue
1998 • 278 citations
Activated Macrophages and the Blood–Brain Barrier: Inflammation after CNS Injury Leads to Increases in Putative Inhibitory Molecules
1997 • 274 citations
Immunocytochemical localization of native chondroitin-sulfate in tissues and cultured cells using specific monoclonal antibody
1984 • 266 citations
Blockade of interleukin‐6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury
2004 • 253 citations
Molecular Cloning and Expression of Human UDP-d-Xylose:Proteoglycan Core Protein β-d-Xylosyltransferase and its First Isoform XT-II
2000 • 222 citations
Is astrocyte laminin involved in axon guidance in the mammalian CNS?
1988 • 215 citations
Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors
2003 • 194 citations
Induction of fibronectin gene transcription and mRNA is a primary response to growth-factor stimulation of AKR-2B cells.
1988 • 193 citations
Regulation of chondroitin sulfate synthesis. Effect of beta-xylosides on synthesis of chondroitin sulfate proteoglycan, chondroitin sulfate chains, and core protein.
1977 • 189 citations
Astrocyte-Associated Fibronectin Is Critical for Axonal Regeneration in Adult White Matter
2004 • 188 citations
Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuries
2004 • 185 citations
Transient Transgene Expression of Decorin in the Lung Reduces the Fibrotic Response to Bleomycin
2001 • 184 citations
A Novel DNA Enzyme Reduces Glycosaminoglycan Chains in the Glial Scar and Allows Microtransplanted Dorsal Root Ganglia Axons to Regenerate beyond Lesions in the Spinal Cord
2004 • 184 citations
Gene expression profiling of acute spinal cord injury reveals spreading inflammatory signals and neuron loss
2001 • 150 citations
Transcriptional coactivator PGC-1α regulates chondrogenesis via association with Sox9
2005 • 148 citations
Growth cone guidance by substrate-bound laminin pathways is correlated with neuron-to-pathway adhesivity
1988 • 144 citations
Expression of TGFβ2 but Not TGFβ1 Correlates with the Deposition of Scar Tissue in the Lesioned Spinal Cord
2002 • 131 citations
Molecular Cloning and Expression of Chick Chondrocyte Chondroitin 6-Sulfotransferase
1995 • 125 citations
Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins
2006 • 124 citations
Inhibition of glial scarring in the injured rat brain by a recombinant human monoclonal antibody to transforming growth factor‐β2
1999 • 123 citations
Transforming Growth Factor-β Signaling in Epithelial Cells
1997 • 113 citations
Molecular Cloning and Expression of Chondroitin 4-Sulfotransferase
2000 • 106 citations
Decorin Attenuates Gliotic Scar Formation in the Rat Cerebral Hemisphere
1999 • 105 citations
Astroglial permissivity for neuritic outgrowth in neuron–astrocyte cocultures depends on regulation of laminin bioavailability
2001 • 96 citations
Transforming growth factor β1 and fibronectin messenger RNA in rat brain: Responses to injury and cell-type localization
1993 • 96 citations
Astroglia‐released neurite growth‐inducing activity for embryonic hippocampal neurons is associated with laminin bound in a sulfated complex and free fibronectin
1989 • 93 citations
Increase in glial fibrillary acidic protein following neural trauma
1990 • 82 citations
Astrocytes from adult rat optic nerves are nonpermissive for regenerating retinal ganglion cell axons
1995 • 82 citations
Selective interaction of peripheral and central nervous system cells with two distinct cell-binding domains of fibronectin.
1987 • 82 citations
Reactive astrocytes involved in the formation of lesional scars differ in the mediobasal hypothalamus and in other forebrain regions
1993 • 81 citations
The proliferative response of astrocytes to injury in neonatal rat brain. A combined immunocytochemical and autoradiographic study
1988 • 81 citations
Role of IL-6 in Spinal Cord Injury in a Mouse Model
2005 • 77 citations
An analysis of astrocytic cell lines with different abilities to promote axon growth
1995 • 71 citations
Initiation of chondroitin sulfate biosynthesis: A kinetic analysis of UDP-D-xylose:core protein .beta.-D-xylosyltransferase
1991 • 70 citations
Extracellular matrix of cultured glial cells: Selective expression of chondroitin 4-sulfate by type-2 astrocytes and their progenitors
1990 • 59 citations
Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals
2005 • 47 citations
Sox group E gene expression distinguishes different types and maturational stages of glial cells in developing chick and mouse
2005 • 35 citations
Animal models of systemic sclerosis: insights into systemic sclerosis pathogenesis and potential therapeutic approaches
2004 • 31 citations
Ascorbic acid transport in mouse and rat astrocytes is reversibly inhibited by furosemide, SITS, and DIDS
1989 • 27 citations
Regeneration of adult rat spinal cord is promoted by the soluble KDI domain of γ1 laminin
2004 • 25 citations
Differential gene expression profiles in embryonic, adult-injured and adult-uninjured rat spinal cords
2003 • 19 citations