Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via phosphatidylinositol 3-kinase.

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Protein modules and signalling networks

1995 • 2,447 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Natural history of hepatocellular carcinoma and prognosis in relation to treatment study of 850 patients

1985 • 1,928 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1994 • 983 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

SH2 and SH3 domains

1993 • 697 citations

Emerging Multipotent Aspects of Hepatocyte Growth Factor

1996 • 662 citations

Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures.

1986 • 588 citations

Hepatocyte growth factor gene therapy of liver cirrhosis in rats

1999 • 587 citations

The pathway to signal achievement

1993 • 563 citations

Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors

1991 • 491 citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

1991 • 481 citations

Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

1997 • 444 citations

Hepatocyte growth factor receptor and the c-met oncogene Bottaro DP, Rubin JS, Faletto DL, Chan AM-L, Kmiecik TE, Vande Woude GF, Aaronson SA. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991;251:802?804

1991 • 434 citations

Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement.

1989 • 411 citations

Hepatocyte growth factor: a multifunctional cytokine

1995 • 324 citations

Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells.

1994 • 320 citations

Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells.

1992 • 256 citations

Hepatocyte Growth Factor-induced Scatter of Madin-Darby Canine Kidney Cells Requires Phosphatidylinositol 3-Kinase

1995 • 239 citations

Hepatocyte growth factor has potent anti‐proliferative activity in various tumor cell lines

1991 • 207 citations

High yield preparation of isolated human adult hepatocytes by enzymatic perfusion of the liver

1982 • 192 citations

Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases.

1988 • 183 citations

The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras.

1994 • 175 citations

Hepatocyte growth factor in transgenic mice: Effects on hepatocyte growth, liver regeneration and gene expression

1994 • 147 citations

Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis.

1994 • 130 citations

Expression of hepatocyte growth factor and its receptor, the c-met proto-oncogene, in hepatocellular carcinoma

1997 • 127 citations

Expression of the c-met protooncogene in human hepatocellular carcinoma

1994 • 122 citations

Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model.

1996 • 120 citations

Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase.

1994 • 110 citations

Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: Involvement of protein tyrosine kinase and protein kinase C

1996 • 80 citations

Comparative effects of hepatocyte growth factor and epidermal growth factor on motility, morphology, mitogenesis, and signal transduction of primary rat hepatocytes

1994 • 79 citations

Platelet-derived growth factor activates membrane-associated phosphatidylinositol 3-kinase and mediates its translocation from the cytosol. Detection of enzyme activity in detergent-solubilized cell extracts

1992 • 64 citations

Hepatocyte growth factor stimulates invasion across reconstituted basement membranes by a new human small intestinal cell line

1994 • 36 citations