Parallel activation of multiple spinal opiate systems appears to mediate ‘non-opiate’ stress-induced analgesias

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Chronic catheterization of the spinal subarachnoid space

1976 • 2,244 citations

Organization of Endogenous Opiate and Nonopiate Pain Control Systems

1982 • 793 citations

Intrinsic Mechanisms of Pain Inhibition: Activation by Stress

1984 • 528 citations

Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.

1988 • 399 citations

Naloxone as a GABA antagonist: Evidence from iontophoretic, receptor binding and convulsant studies

1978 • 330 citations

Multiple opioid systems and pain

1986 • 286 citations

Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor

1972 • 284 citations

Evidence for opioid and non-opioid forms of stimulation-produced analgesia in the rat

1982 • 210 citations

Antinociceptive interactions between alpha 2-adrenergic and opiate agonists at the spinal level in rodents.

1989 • 196 citations

Pharmacological characterization of substance P-induced nociception in mice: modulation by opioid and noradrenergic agonists at the spinal level.

1983 • 193 citations

Antinociceptive Interactions Between Alphha2-Adrenergic and Opiate Agonists at the Spinal Level in Rodents

1989 • 168 citations

Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.

1983 • 153 citations

Chapter 28 Sites of action of opiates in production of analgesia

1988 • 153 citations

In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord

1982 • 148 citations

Opiate vs non-opiate footshock-induced analgesia (FSIA): The body region shocked is a critical factor

1982 • 139 citations

Binaltorphimine-related bivalent ligands and their .kappa. opioid receptor antagonist selectivity

1988 • 137 citations

Novel peptidic mu opioid antagonists: pharmacologic characterization in vitro and in vivo.

1989 • 131 citations

Pharmacology of Dynorphin

1988 • 118 citations

Modulation of the potency and efficacy of mu-mediated antinociception by delta agonists in the mouse.

1990 • 113 citations

Modulation of morphine antinociception by peripheral [Leu5]enkephalin: a synergistic interaction

1990 • 109 citations

Comparison between naloxone reversal of morphine and electrical stimulation induced analgesia in the rat mesencephalon

1976 • 105 citations

Modulation of μ-mediated antinociception by δ agonists in the mouse: selective potentiation of morphine and normorphine by [D-Pen2, D-Pen5]enkephalin

1989 • 99 citations

Stress-Induced Analgesia

2006 • 94 citations

Morphine allosterically modulates the binding of [3H]leucine enkephalin to a particulate fraction of rat brain.

1982 • 91 citations

Opiate vs non-opiate eootshock induced analgesia (FSIA): Descending and intraspinal components

1982 • 90 citations

Kappa opioid analgesia is dependent on serotonergic mechanisms.

1984 • 82 citations

Intrathecal Clonidine Suppresses Noxiously Evoked Activity of Spinal Wide Dynamic Range Neurons in Cats

1989 • 79 citations

Cross tolerance between morphine and the long-term analgesic reaction to inescapable shock

1981 • 78 citations

The influence of opioid receptor subtypes on the processing of nociceptive inputs in the spinal dorsal horn of the cat

1988 • 75 citations

The status of naloxone in the identification of pain control mechanisms operated by endogenous opioids

1981 • 73 citations

Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: Isobolographic analysis

1990 • 71 citations

Stress-Induced Analgesia

1985 • 69 citations

Can supraspinal δ-opioid receptors mediate antinociception?

1988 • 66 citations

Involvement of spinal opioid systems in footshock-induced analgesia: Antagonism by naloxone is possible only before induction of analgesia

1982 • 62 citations

ϰ-Receptor antagonist reverse ‘non-opioid’ stress-induced analgesia

1984 • 58 citations

The potentiation of spinal analgesia by leucine enkephalin

1980 • 58 citations

Opioid and non-opioid mechanisms of stress analgesia: lack of cross-tolerance between stressors

1983 • 54 citations

Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels

1992 • 49 citations

Opiate and non-opiate analgesia induced by inescapable tail-shock: Effects of dorsolateral funiculus lesions and decerebration

1984 • 42 citations

Distinct antinociceptive actions mediated by different opioid receptors in the region of lamina I and laminae III‐V of the dorsal horn of the rat

1990 • 42 citations

Mu antagonist and kappa agonist properties of beta-funaltrexamine (beta-FNA) in vivo: long-lasting spinal analgesia in mice.

1990 • 42 citations

Monoamine and opioid interactions in spinal analgesia and tolerance

1987 • 40 citations

Dynorphin(1–13), a long-lasting inhibitor of opiate receptor binding

1982 • 38 citations

Opioid and nonopioid forms of stress-induced analgesia: some environmental determinants and characteristics

1982 • 36 citations

Leucine enkephalin noncompetitively inhibits the binding of [3H]naloxone to the opiate mu-recognition site: Evidence for delta←mu binding site interactions in vitro

1985 • 32 citations

Differential contribution of descending serotonergic and noradrenergic systems to central Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5 (DAMGO) and morphine-induced antinociception in mice.

1991 • 29 citations

Further evidence for an opioid receptor complex

1983 • 29 citations

A highly selective ligand for brain δ opiate receptors, a ▿ ^EPhe⁴‐enkephalin analog, suppresses μ receptor‐mediated thermal analgesia by morphine

1988 • 28 citations

The dorsal raphe nucleus: A re-evaluation of its proposed role in opiate analgesia systems

1988 • 25 citations

The Antinociceptive Role of ??- and ??-Opiate Receptors and Their Interactions in the Spinal Dorsal Horn of Cats

1990 • 21 citations

A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE

1989 • 20 citations

Evaluation of thyrotropin-releasing hormone as a potential antidepressant agent in the conscious dog

1973 • 20 citations

Electrical stimulation of the rat ventral midbrain elicits antinociception via the dorsolateral funiculus

1989 • 12 citations