Role of Symbol and opiate receptors in nociception during and after ischaemia in rats

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8.

1957 • 1,671 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

1987 • 373 citations

A cure for wind up: NMDA receptor antagonists as potential analgesics

1990 • 327 citations

Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat

1990 • 310 citations

Opiate Receptor Mediation of Ketamine Analgesia

1982 • 206 citations

The sensitization of high threshold mechanoreceptors with myelinated axons by repeated heating.

1977 • 194 citations

Ketamine acts as a non-competitive N-methyl-d-aspartate antagonist on frog spinal cord in vitro

1985 • 180 citations

The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats

1984 • 172 citations

Response latencies in the tail-flick test depend on tail skin temperature

1988 • 170 citations

ANALGESIC EFFECTS OF KETAMINE ADMINISTERED IN SUBDISSOCIATIVE DOSES

1972 • 164 citations

Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats

1981 • 149 citations

Comparison of ketamine and pethidine in experimental and postoperative pain

1989 • 148 citations

Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model

1991 • 145 citations

A preliminary procedure for the evaluation of central nervous system depressants.

1957 • 126 citations

Analgesia and hyperalgesia produced in the rat by intrathecal naloxone

1980 • 122 citations

Low doses of naloxone produce analgesia in the mouse brain by blocking presynaptic autoinhibition of enkephalin release

1986 • 115 citations

Excitatory amino acid receptors and synaptic transmission in the rat ventrobasal thalamus.

1987 • 107 citations

An improved method for tail-flick testing with adjustment for tail-skin temperature

1989 • 106 citations

Pain and hyperalgesia following tissue injury: new mechanisms and new treatments

1991 • 81 citations

Pharmacological antagonists of excitant amino acid action

1981 • 77 citations

Analgesia from morphine and ketamine.

1987 • 75 citations

First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist

1986 • 69 citations

Endogenous opiates and nociception: A possible functional role in both pain inhibition and detection as revealed by intrathecal naloxone

1981 • 68 citations

Apparent hyperalgesia after lesions of the descending serotonergic pathways is due to increased tail skin temperature

1988 • 65 citations

Analgesia produced by normal doses of opioid antagonists alone and in combination with morphine

1989 • 61 citations

N-methyl-d-aspartate receptors mediate responses of rat dorsal horn neurones to hindlimb ischemia

1990 • 58 citations

Intrathecal induces hyperexcitability in rat dorsal horn convergent neurones

1990 • 55 citations

Opioid antagonist, endogenous ligands and nociception

1977 • 49 citations

Ketamine analgesia is not related to an opiate action in the periaqueductal gray region of the rat brain

1985 • 47 citations

Antagonism of N‐methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK‐801

1988 • 43 citations

Hyperalgesia following ischaemia of the ratʼs tail

1986 • 42 citations

The apparent antinociceptive effect of desipramine and zimelidine in the tail flick test in rats is mainly caused by changes in tail skin temperature

1989 • 31 citations

Influence of certain parameters on the performance of mice on the rotarod.

1967 • 28 citations

Lack of antagonism by naloxone of the analgesic and locomotor stimulant actions of ketamine

1982 • 23 citations

Effects of ketamine on nociception and gastrointestinal motility in mice are unaffected by naloxone

1987 • 23 citations

Injectable aspirin and mepyramine abolish post-ischaemic hyperalgesia in rats

1986 • 20 citations

Behavioral correlates of naloxone inhibition of analgesia induced by various CNS excitatory drugs in the rat.

1978 • 11 citations

Behavioural and thalamic nociceptive responses in rats following noxious ischaemia of the tail

1988 • 11 citations

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