Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene.

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

1992 • 5,105 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

‘Touchdown’ PCR to circumvent spurious priming during gene amplification

1991 • 2,630 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Identification of differentially expressed mRNA species by an improved disply technique (DDRT-PCR)

1993 • 523 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1993 • 332 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

1992 • 315 citations

seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye

1990 • 313 citations

Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes

1995 • 293 citations

Tumor suppressor genes

1994 • 206 citations

Familial Multiple Endocrine Neoplasia Type I: A New Look at Pathophysiology

1987 • 186 citations

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes.

1993 • 152 citations

Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina)

1993 • 135 citations

Purification, molecular cloning, and sequencing of phospholipase C-beta 4.

1993 • 120 citations

Drosophila in cancer research: the first fifty tumor suppressor genes

1994 • 109 citations

Multiple forms of phospholipase C isozymes and their activation mechanisms.

1992 • 88 citations

Chapter 2 Localization of mRNAs by in Situ Hybridization

1991 • 85 citations

Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1)

1994 • 47 citations

Identification of genes that interact with the sina gene in Drosophila eye development.

1994 • 42 citations

Cloning of cDNA Encoding Rat Phospholipase C-β4, a New Member of the Phospholipase C

1993 • 25 citations

Reflectance in situ hybridization (RISH): detection, by confocal reflectance laser microscopy, of gold‐labelled riboprobes in breast cancer cell lines and histological specimens

1994 • 24 citations

Expression of Siah-2, a vertebrate homologue of Drosophila sina, in germ cells of the mouse ovary and testis

1995 • 16 citations

Assignment of the mouse homologue of a human MEN1 candidate gene, phospholipase C-β3 (Plcb3), to chromosome region 19B by FISH

1995 • 3 citations